Effect of Medium-chain Triacylglycerols on Anti-obesity Effect of Fucoxanthin

Anti‐obese property of fucoxanthin is partly mediated by altering lipid‐regulating enzymes and uncoupling proteins of visceral adipose tissue in mice

“…In this study, two doses of fucoxanthin, supplemented with 0.05 and 0.2% level in diet, significantly lowered the plasma leptin concentration compared with the control group, whereas it significantly elevated adiponectin concentration. In contrast to the findings in this study, 0.1% dietary fucoxanthin provided to KK-A y mice did not alter plasma leptin or adiponectin concentration, but 0.2% fucoxanthin only significantly lowered plasma leptin levels [7,30]. Adiponectin is very highly expressed in adipose tissues and it can increase b-oxidation in tissues and causes weight loss in mice [31].…”

“…Thus, high doses of fucoxanthin seemingly enhanced the thermogenic capacity of BAT compared with those of control mice and low doses of fucoxanthin resulted induction of the UCP1 gene expression in WAT. In Maeda et al's findings, 0.4 [3], 0.15 [7] and 0.2% [30] levels of dietary fucoxanthin, those are higher doses than 0.05% in which were used in this study, resulted to increase the UCP1 gene expression in WAT of KK-A y mice. In conclusion, this study provided direct evidence that dietary fucoxanthin, even with a 0.05% dose, can exhibit potential anti-obesity effect in high-fat diet-induced mice, which may be mediated by altering plasma adipokine level, down-regulating fat production while up-regulating b-oxidation and UCP gene expressions in visceral adipose tissues.…”

Functional and Nutraceutical Ingredients from Marine Macroalgae

“…The mechanism of their anti-obesity properties may be related to the up-regulation of the expression of the fat-burning protein UCP1 (uncoupling protein 1 or thermogenin) in WAT around the internal organs [38]. Fucoxanthin-induced expression of UCP1 in WAT results in the oxidation of fatty acids and heat generation, which directly reduce abdominal fat in animals [39].…”

Obesity and Related Disorders

“…Uncoupling protein-1 is usually expressed in brown adipose tissue and functions to release chemical energy and induce heat production. However, it has been found that feeding of fucoxanthin increases uncoupling protein-1 expression in white adipose tissue, which in turn leads to fatty acid oxidation and energy expenditure, and ultimately reduces fat mass (Maeda et al 2007). Xanthigen is an extract from deep seawater-cultivated marine vegetables standardized to fucoxanthin, neoxanthin and violaxanthin with stronger thermogenic and weight control properties (Humphries 2007).…”