Effect of medium‐chain fatty acid positional distribution in dietary triacylglycerol on lymphatic lipid transport and chylomicron composition in rats

Carvajal, Octavio; Nakayama, Masahiro; Kishi, Taiji; Sato, Masao; Ikeda, Ikuo; Sugano, Michihiro; Imaizumi, Kazunori

doi:10.1007/s11745-000-0651-6

Cited by 22 publications

(20 citation statements)

References 34 publications

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“…44 Furthermore, esterified FA10:0 found in the plasma may also be contributed by chylomicrons, since possible integration of dietary MCFA into chylomicrons cannot be excluded. [45][46][47][48][49] Nonetheless, these MCFA-containing triglyceride-rich lipoproteins can be important substrates for lipoprotein lipase in the capillaries of adipose tissues, skeleton, and cardiac muscles. The MCFA that are taken up by adipose tissues can be stored and subsequently released into the circulation, depending upon the feed/fast cycle.…”

Section: Esterified Capric Acid Concentrationmentioning

confidence: 99%

Change in Plasma Total, Esterified and Non-esterified Capric Acid Concentrations during a Short-term Oral Administration of Synthetic Tricaprin in Dogs

et al. 2017

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We studied change in the plasma total, esterified and non-esterified capric acid (FA10:0) and its effect on longer fatty acid concentrations during the short-term oral administration of synthetic tricaprin in dogs. We administered 150 and 1500 mg tricaprin/kg body weight per day orally to dogs for 7 consecutive days. Blood samples were collected at 0, 0.5, 1, 2, 4, 8, and 24 h on the 1st and 7th days for measuring the total-, esterified-and non-esterified-FA10:0. The total-FA10:0 concentration increased in a dose-dependent manner, reaching a peak at 1 h on the 1st day and at 2 to 4 h on the 7th day; it then mostly disappeared within 24 h. The mean esterified FA10:0 concentration was found be 75.5 and 60.3% of total-FA10:0 in dogs fed 150 and 1500 mg of tricaprin/kg body weight, respectively. The plasma level of FA10:0 depends on the duration and dose of tricaprin administration, but are rapidly cleared from circulation within several hours.

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Section: Esterified Capric Acid Concentrationmentioning

confidence: 99%

Change in Plasma Total, Esterified and Non-esterified Capric Acid Concentrations during a Short-term Oral Administration of Synthetic Tricaprin in Dogs

et al. 2017

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“…The two lipids are differently transported in the body, MCT is directly transported by the portal blood to the systemic circulation , whereas LCT is transported in the intestinal lymphatics. However, some of the medium-chain saturated fatty acids are resynthesized or re-esterified to triacylglycerols or neutral lipids, packaged within apoprotein surface layers and transported via the lymphatic system (Green & Glickman, 1981;Ikeda et al, 1991;Carvajal et al, 2000;Mu & Hoy, 2001;Holm et al, 2002). Recently, Sun et al (2011) have reported that, the lymphatic transport of sirolimus from SMEDDS formulation containing !25% MCT was a major contributor to its oral bioavailability.…”

Section: Introductionmentioning

confidence: 99%

Role of lipid-based excipients and their composition on the bioavailability of antiretroviral self-emulsifying formulations

Chudasama

Patel

Nivsarkar³

et al. 2014

Drug Delivery

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The objective of this study was to develop self-emulsifying drug delivery system (SEDDS) to improve solubility and enhance the oral absorption of the poorly water-soluble drug, nevirapine. This lipid-based formulation may help to target the drug to lymphoid organs where HIV-1 virus resides mainly. The influence of the oil, surfactant and co-surfactant types on the drug solubility and their ratios on forming efficient and stable SEDDS were investigated in detail. Two SEDDS (F1 and F2) were prepared and characterized by morphological observation, droplet size and zeta potential determination, cloud point measurement and in vitro diffusion study. The influence of droplet size on the absorption from formulations with varying concentration of oil and surfactant was also evaluated from two self-emulsifying formulations. Oral bioavailability of nevirapine SEDDS was checked by using rat model. Results of diffusion rate and oral bioavailability of nevirapine SEDDS were compared with marketed suspension. The absorption of nevirapine from F1 and F2 showed 1.92 and 1.98-fold increase (p50.05) in relative bioavailability, respectively, compared with that of the suspension. There was no statistical significant difference (p50.05) between F1 and F2 in their AUC and C max . This indicated that there was apparent poor correlation between the droplet size and in vivo absorption. However, nevirapine in SEDDS showed higher ex vivo stomach and intestinal permeability and in vivo absorption than the marketed suspension, suggesting that the SEDDS may be a useful delivery system for targeting nevirapine to lymphoid organs.

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“…However, molecular-level effects of TAG with similar FA compositions but different positional distributions of FA have previously been compared in the rat model only. In these studies MCFA have been absorbed via the portal venous system as well as incorporated into chylomicron TAG (2)(3)(4)(5). The proportion of MCFA incorporated into chylomicrons has depended on the position of the MCFA in the TAG molecule (2,6), and the overall lymph flow or TAG output has (7) or has not (5) been affected by the location of the MCFA.…”

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confidence: 99%

Positional distribution of decanoic acid: Effect on chylomicron and VLDL TAG structures and postprandial lipemia

Yli-Jokipii

Schwab

Tahvonen

et al. 2004

Lipids

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Although medium-chain FA (MCFA) are mainly absorbed via the portal venous system, they are also incorporated into chylomicron TAG; therefore, the positional distribution of MCFA in TAG is likely to affect their metabolic fate. We studied chylomicron and VLDL TAG structures, as well as the magnitude of postprandial lipemia, after two oral fat loads containing decanoic acid (10:0) predominantly at the sn-1(3),2 (MML) or at the sn-1,3 positions (MLM) of TAG in a randomized, double-blind, crossover clinical trial with 10 healthy, normal-weight volunteers. An MS-MS method was used to analyze TAG regioisomers. The position of decanoic acid in chylomicron TAG reflected its position in the TAG ingested, and TAG with none, one, two, or three decanoic acid residues were detected after ingestion of both fats. More (P < 0.05) 30:0 and 38:1 TAG (acyl carbons:double bonds) and fewer 46:5, 54:5, and 54:4 TAG were found in chylomicrons after ingestion of MML than after MLM. The VLDL TAG composition did not differ between the fat loads but did change (P < 0.05) 2 to 6 h after ingestion of both fats. No statistical differences were seen between the fat loads in areas under the plasma, chylomicron, or VLDL TAG response curves or in FFA concentrations. Thus, the positional distribution of MCFA in TAG affects their metabolic fate, but the magnitude of postprandial lipemia does not seem to be dependent on the positional distribution of MCFA in the ingested fat.

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Effect of medium‐chain fatty acid positional distribution in dietary triacylglycerol on lymphatic lipid transport and chylomicron composition in rats

Cited by 22 publications

References 34 publications

Change in Plasma Total, Esterified and Non-esterified Capric Acid Concentrations during a Short-term Oral Administration of Synthetic Tricaprin in Dogs

Change in Plasma Total, Esterified and Non-esterified Capric Acid Concentrations during a Short-term Oral Administration of Synthetic Tricaprin in Dogs

Role of lipid-based excipients and their composition on the bioavailability of antiretroviral self-emulsifying formulations

Positional distribution of decanoic acid: Effect on chylomicron and VLDL TAG structures and postprandial lipemia

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