Effect of mechanical stimulation on the degradation of poly(lactic acid) scaffolds with different designed structures

Shui, Hengtao; Shi, Quan; Pugno, Nicola; Chen, Qiang; Li, Zhi Yong

doi:10.1016/j.jmbbm.2019.04.028

Cited by 23 publications

(10 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Enhancing the osteogenic differentiation of MSCs by applying mechanical stretch (compression) stimuli to scaffolds is proven to be an effective therapeutic strategy. At the same time, physical stimulation also affects the physicochemical properties of the scaffold; for example, the loading of mechanical force significantly increases the degradation rate of the polylactic acid (PLA) scaffold [ 114 ]. On this basis, researchers have further explored the effect of physical stimulation on the inflammatory microenvironment of bone scaffolds.…”

Section: Inflammation Under the Mechanical Environment In Bone Scaffoldsmentioning

confidence: 99%

Inflammation Responses to Bone Scaffolds under Mechanical Stimuli in Bone Regeneration

Wang

Yuan

Yin

et al. 2023

JFB

View full text Add to dashboard Cite

Physical stimuli play an important role in one tissue engineering. Mechanical stimuli, such as ultrasound with cyclic loading, are widely used to promote bone osteogenesis; however, the inflammatory response under physical stimuli has not been well studied. In this paper, the signaling pathways related to inflammatory responses in bone tissue engineering are evaluated, and the application of physical stimulation to promote osteogenesis and its related mechanisms are reviewed in detail; in particular, how physical stimulation alleviates inflammatory responses during transplantation when employing a bone scaffolding strategy is discussed. It is concluded that physical stimulation (e.g., ultrasound and cyclic stress) helps to promote osteogenesis while reducing the inflammatory response. In addition, apart from 2D cell culture, more consideration should be given to the mechanical stimuli applied to 3D scaffolds and the effects of different force moduli while evaluating inflammatory responses. This will facilitate the application of physiotherapy in bone tissue engineering.

show abstract

Section: Inflammation Under the Mechanical Environment In Bone Scaffoldsmentioning

confidence: 99%

Inflammation Responses to Bone Scaffolds under Mechanical Stimuli in Bone Regeneration

Wang

Yuan

Yin

et al. 2023

JFB

View full text Add to dashboard Cite

show abstract

“…The scaffolds shared a periodic structure with porosity 64.8%. The designed topological structure with a representative volume element (RVE) ( Shui et al, 2019 ) is shown in Figure 1C .…”

Section: In Vitro Experimentsmentioning

confidence: 99%

Degradation of 3D-Printed Porous Polylactic Acid Scaffolds Under Mechanical Stimulus

Chen

Shi

Shui

et al. 2021

Front. Bioeng. Biotechnol.

Self Cite

View full text Add to dashboard Cite

Polylactic acid (PLA) is a biodegradable polymer commonly used as a scaffold material to repair tissue defects, and its degradation is associated with mechanical stimulus. In this study, the effect of mechanical stimulus on the degradation of 3D-printed PLA scaffolds was investigated by in vitro experiments and an author-developed numerical model. Forty-five samples with porosity 64.8% were printed to carry out the degradation experiment within 90 days. Statistical analyses of the mass, volume fraction, Young’s modulus, and number average molecular weight were made, and the in vitro experiments were further used to verify the proposed numerical model of the scaffold degradation. The results indicated that the mechanical stimulus accelerated the degradation of the PLA scaffold, and the higher mechanical stimulus led to a faster degradation of the scaffolds at the late stage of the degradation process. In addition, the Young’s modulus and the normalized number average molecular weight of the PLA scaffolds between the experiments and the numerical simulations were comparable, especially for the number average molecular weight. The present study could be helpful in the design of the biodegradable PLA scaffolds.

show abstract

“…By substituting equation (10) into equation ( 7) and considering equation (11), the implicit form of the evolution law is reached:…”

Section: Constitutive Equations and Thermodynamical Considerationsmentioning

confidence: 99%

“…For example, in biodegradable materials, there is the danger of in-vivo experiments, expensive cost, and the requirement of advanced empirical techniques [10]. The probabilistic and phenomenological approaches are frequently applied to studies on degradation [11]. The probabilistic models are based on random chain scission of polymers and implemented with methods such as Monte Carlo and cellular automata.…”

Section: Introductionmentioning

confidence: 99%

A study on deformation-induced degradation of the compressible polymeric pressurized vessel through a non-equilibrium thermodynamic framework

Kazemian

Goudarzi

Hassani

2021

Mathematics and Mechanics of Solids

View full text Add to dashboard Cite

The present paper investigates the degradation of compressible polymers based on the proposed model on strain-induced degradation of incompressible polymers. In a non-equilibrium thermodynamic framework, constitutive equations and evolution laws are derived using the principle of maximum energy dissipation rate and specifying how energy can be stored and dissipated. As a computational model, the governing equations are applied to the pressurized polymeric vessel subjected to the Ogden–Hill compressible hyperelastic material model. To analyze the axisymmetric plane-strain degradable vessel, programming in ANSYS Parametric Design Language (APDL) and the Standard Galerkin Finite Element Method (SGFEM) are applied. The results show that the degradable compressible Ogden–Hill model can also predict the degradation of incompressible polymers subjected to the neo-Hookean model. Results also reveal that the highest dissipation rate and material softening occur at the inner radius of the inflated degradable vessel. Creep-like and stress-relaxation-like responses of the polymeric vessel with time-position-dependent material properties are examined. ANSYS coding indicates good accuracy and efficiency in studying the compressible vessel subjected to inhomogeneous degradation.

show abstract

Effect of mechanical stimulation on the degradation of poly(lactic acid) scaffolds with different designed structures

Cited by 23 publications

References 52 publications

Inflammation Responses to Bone Scaffolds under Mechanical Stimuli in Bone Regeneration

Inflammation Responses to Bone Scaffolds under Mechanical Stimuli in Bone Regeneration

Degradation of 3D-Printed Porous Polylactic Acid Scaffolds Under Mechanical Stimulus

A study on deformation-induced degradation of the compressible polymeric pressurized vessel through a non-equilibrium thermodynamic framework

Contact Info

Product

Resources

About