Effect of Maternal Obesity on Foetal Growth and Metabolic Health of the Offspring

Maffeis, Claudio; Morandi, Anita

doi:10.1159/000456668

Cited by 36 publications

(29 citation statements)

References 35 publications

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“…Several studies have shown that MO during gestation is an important determinant of offspring weight (Villamor & Cnattingius, 2006;Samuelsson et al 2008;Zambrano et al 2010;Maffeis & Morandi, 2017;Wang et al 2019). We have previously reported that even when MOF 1 eat a normal control laboratory diet, they exhibit increased body weight, fat and adiposity index (Zambrano et al 2010;Vega et al 2015).…”

Section: Discussionmentioning

confidence: 88%

Maternal obesity accelerates rat offspring metabolic ageing in a sex‐dependent manner

Rodríguez-González

Reyes-Castro

Bautista

et al. 2019

The Journal of Physiology

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Key points Maternal obesity predisposes to metabolic dysfunction in male and female offspring Maternal high‐fat diet consumption prior to and throughout pregnancy and lactation accelerates offspring metabolic ageing in a sex‐dependent manner This study provides evidence for programming‐ageing interactions Abstract Human epidemiological studies show that maternal obesity (MO) shortens offspring life and health span. Life course cellular mechanisms involved in this developmental programming‐ageing interaction are poorly understood. In a well‐established rat MO model, female Wistar rats ate chow (controls (C)) or high energy, obesogenic diet to induce MO from weaning through pregnancy and lactation. Females were bred at postnatal day (PND) 120. Offspring (F1) of mothers on control diet (CF1) and MO diet (MOF1) delivered spontaneously at terms. Both CF1 and MOF1 ate C diet from weaning throughout the study. Offspring were killed at PND 36, 110, 450 and 650. We determined body and liver weights, liver and serum metabolite concentrations, hormones and oxidative stress biomarkers. Male and female CF1 body weight, total fat, adiposity index, serum leptin, insulin, insulin resistance, and liver weight, fat, triglycerides, malondialdehyde, reactive oxygen species and nitrotyrosine all rose with differing ageing trajectories. Female CF1 triglycerides were unchanged with age. Age‐related increases were greater in MOF1 than CF1 in both sexes for all variables except glucose in males and females and cholesterol in males. Cholesterol fell in CF1 females but not MOF1. Serum corticosterone levels were higher in male and female MOF1 than CF1 and declined with age. DHEA serum levels were lower in male and female MOF1 than CF1. Liver antioxidant enzymes decreased with age (CF1 and MOF1). Conclusions: exposure to the developmental challenge of MO accelerates progeny ageing metabolic and endocrine profiles in a sex specific manner, providing evidence for programming‐ageing interactions.

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Section: Discussionmentioning

confidence: 88%

Maternal obesity accelerates rat offspring metabolic ageing in a sex‐dependent manner

Rodríguez-González

Reyes-Castro

Bautista

et al. 2019

The Journal of Physiology

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“…The offspring of obese, but not normal-weight mothers in another study demonstrated downregulation of the glycolysis pathway (p=0.049) 55 . Recent research showed that increase in hepatic gluconeogenesis was a major source of the total maternal glucose used by the fetus 56 . Interestingly, 1,5-anhydrosorbitol, which has been shown to be a maternal marker of short-term glycemic control, was observed in our cord blood study as a marker too, likely from maternal origin.…”

Section: Discussionmentioning

confidence: 99%

Pre-pregnant obesity of mothers in a multi-ethnic cohort is associated with cord blood metabolomic changes in offspring

Alakwaa

Schlueter

Xie

et al. 2018

Preprint

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Maternal obesity has become a growing global health concern that impacts fetal health and subsequently predisposes the offspring to medical conditions later in life. However, the molecular link between abnormal fetal metabolomic profiles and maternal obesity has not yet been fully elucidated. In this study, we report new discoveries from the newborn cord blood metabolomes associated with a case-control maternal obesity cohort, collected from multi-ethnic populations in Hawaii, including rarely reported Native Hawaiian and other Pacific Islanders (NHPI). This cohort displays significant maternal obesity disparities by subjects' residential area average income and health insurance. An elastic net penalized logistic regression model was constructed to associate cord blood metabolomics and demographic/physiological information to maternal obesity, with accuracy as high as 0.947. We identify 29 metabolites as early-life biomarkers manifesting intrauterine effect of maternal obesity.

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“…The concern with obesity is increased by the fact that some data show that genes play an important role in predisposing individuals to obesity, showing that having one or both of the obese parents, especially the mother, increases the risk of obesity in the offspring [23]. Women who are overweight or obese when they enter pregnancy are more likely to have children more likely to develop obesity during childhood, adolescence, and adulthood [24].…”

Section: The Etiology Of Obesitymentioning

confidence: 99%

Zebrafish as an Experimental Model for the Study of Obesity

Virote¹,

Vianna²,

Murgas³

2020

Zebrafish in Biomedical Research

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Obesity is considered a silent global pandemic, with a steady increase in adults and children. It is a complex disease that involves the interaction of genetic and environmental factors and predisposes individuals to severe chronic complications such as various types of cancer, dyslipidemia, hyperglycemia, hypercholesterolemia, nonalcoholic fatty liver disease (NAFLD), and nonalcoholic steatohepatitis. To help elucidate the physiological mechanisms of this comorbidity in order to identify and develop effective treatments, the use of animal models is indispensable. Zebrafish is emerging as an important model for studying obesity and related metabolic diseases. In addition to being a small animal, with high genetic similarity when compared to humans and easy to handle, zebrafish also has the main well-conserved metabolism-related functions such as appetite regulation, insulin regulation, and lipid storage. Zebrafish is also suitable for the identification of new targets associated with the risk and treatment of obesity in humans. In this review, we highlight the studies that use zebrafish to study metabolic diseases demonstrating their important contribution in this area of research.

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Effect of Maternal Obesity on Foetal Growth and Metabolic Health of the Offspring

Cited by 36 publications

References 35 publications

Maternal obesity accelerates rat offspring metabolic ageing in a sex‐dependent manner

Maternal obesity accelerates rat offspring metabolic ageing in a sex‐dependent manner

Pre-pregnant obesity of mothers in a multi-ethnic cohort is associated with cord blood metabolomic changes in offspring

Zebrafish as an Experimental Model for the Study of Obesity

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