Effect of maternal micronutrients (folic acid and vitamin B12) and omega 3 fatty acids on indices of brain oxidative stress in the offspring

Roy, Suchitra; Sable, Pratiksha; Khaire, Amrita; Randhir, Karuna; Kale, Anvita; Joshi, S. K.

doi:10.1016/j.braindev.2013.03.004

Cited by 39 publications

(22 citation statements)

References 27 publications

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“…So far, many different maternal programming factors have been discovered (for example over- or undernutrition [33-35], lack of micronutrients [36, 37], and stress during pregnancy [38-40]). However, more recent studies showed that also paternal exposure to adverse environmental conditions can act on the offspring’s phenotype in terms of fetal programming and influence later life disease risk [11, 28].…”

Section: Discussionmentioning

confidence: 99%

Paternal Programming of Liver Function and Lipid Profile Induced by a Paternal Pre-Conceptional Unhealthy Diet: Potential Association with Altered Gut Microbiome Composition

Zhang¹,

Dong²,

Sun³

et al. 2019

Kidney Blood Press Res

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Background/Aims: Paternal exposure to adverse environmental conditions can act on offspring’s phenotype and influence offspring’s later life disease risk. Our study was designed to examine the effect of feeding male rats before mating a high-fat, high-sucrose and high-salt diet (HFSSD) over two generations (F0 and F1) on their offspring’s (F2) liver function and gut microbiome composition. Methods: Male F0 rats and male F1 rats were fed either control diet or HFSSD before mating. Liver function of F2 offspring was investigated, and their gut microbiome composition was analyzed by 16S rRNA gene sequencing in the F2 offspring of rats whose fathers and grandfathers were fed with control diet (CD) (F0CD+F1CD-F2 group) or HFSSD prior to mating (F0HD+F1HD-F2 group). Results: F2 offspring had higher serum aspartate aminotransferase activity (female, p < 0.05 and male, p < 0.01 respectively) compared with control. Shannon indexes of gut microbiota indicated a significantly higher diversity in the female F0HD+F1HD-F2 as compared to F0CD+F1CD-F2 female offspring (p < 0.01). The dominant phyla of all the groups were Bacteroidetes, Firmicutes and Proteobacteria. There were significant differences in gut bacterial community composition at phyla and genus level between the F0CD+F1CD-F2 and F0HD+F1HD-F2. Furthermore, the variation in the relative abundance (percentage) of bacterial genus in the F2 offspring was associated with liver function alterations induced by a paternal pre-conceptional unhealthy diet. Male F0HD+F1HD-F2 offspring had higher serum cholesterol, high density lipoproteins as well as low density lipoproteins concentrations compared to the corresponding male control rats. Conclusion: Taken together, our findings suggested that a paternal pre-conceptional unhealthy diet predisposes the offspring to mild liver function alterations and alterations of gut microbiota in later life. Effects on lipids were sex-specific and only seen in male offspring.

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Section: Discussionmentioning

confidence: 99%

Paternal Programming of Liver Function and Lipid Profile Induced by a Paternal Pre-Conceptional Unhealthy Diet: Potential Association with Altered Gut Microbiome Composition

Zhang¹,

Dong²,

Sun³

et al. 2019

Kidney Blood Press Res

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“…Rats fed a maternal high FA and low B12 diet had pups with lower mRNA levels of two key enzymes in the methyl donor metabolic pathway, MTHFR and methionine synthase (Khot et al, 2014). Mother rats with an imbalance in B12 have pups with reduced antioxidant enzymes at birth, while brain oxidative stress was higher in pups of mothers given a high FA and low B12 diet (Roy et al, 2014). Pups of rat mothers given a high FA diet were at increased risk for mammary adenocarcinomas if kept on the FA diet postweaning, while maternal FA supplementation was linked to accelerated development of the same mammary tumors in offspring (Ly et al, 2011).…”

Section: Animal Studies On Effects Of Altering Methyl Donor Intakementioning

confidence: 95%

Consequences of dietary methyl donor supplements: Is more always better?

Shorter

Felder

Vrana

2015

Progress in Biophysics and Molecular Biology

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“…With increased intake of anti-oxidant, it is believed that the gestational oxidative stress can be minimized. In animal model, maternal supplementation of folic acid, B12, and omega 3 fatty acid significantly reduce the brain oxidative stress in the offspring 12 . When mothers were following the recommendation prenatal and during pregnancy, the optimal health outcomes in the child at age 10 (relative to peers) would be normal BMI relatively to their age and low risk factor for metabolic syndrome such as normal systolic blood pressure.…”

Section: Iugrmentioning

confidence: 97%

Bagaimana Gizi Sejak Massa Konsepsi Dapat Mempengaruhi Kesehatan Biologis Anak?

Mahmudiono

2017

AMNT

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ABSTRAKLatar Belakang: gizi yang baik bagi ibu sejak masa pra konsepsi dan konsepsi merupakan persiapan yang penting untuk kesehatan janin dan anak dimasa dating. Tujuan: tujuan dalam penulisan literature review ini adalah untuk menjelaskan secara argumentative bagaimana gizi sejak masa konsepsi dapat mempengaruhi kesehatan biologis anak. Pembahasan: hasil literature review menunjukkan bukti bahwa gizi sejak masa konsepsi dapat mempengaruhi kesehatan biologis anak. Beberapa artikel menunjukkan mekanisme yang menjelaskan kemungkinan mekanisme pengaruh gizi saat konsepsi terhadap kesehatan biologis anak dimasa datang seperti halnya Barker Hyphothesis atau fetal programming. Namun begitu, data yang diperoleh hingga saat ini masih belum meyakinkan sepenuhnya. Untuk itu perlu dikembangkan penelitian yang panjang atau longitudinal dan eksperimental yang dapat menggaransi kebenaran teori tersebut. Kesimpulan: argumentasi bahwa gizi sejak masa konsepsi diyakini berpengaruh terhadap kesehatan biologis anak dimasa depan semakin menguat dalam literature terkini walaupun bukti hasil penelitian eksperimental masih perlu banyak diakumulasikan untuk memastikan kebenarannya.

show abstract

Effect of maternal micronutrients (folic acid and vitamin B12) and omega 3 fatty acids on indices of brain oxidative stress in the offspring

Cited by 39 publications

References 27 publications

Paternal Programming of Liver Function and Lipid Profile Induced by a Paternal Pre-Conceptional Unhealthy Diet: Potential Association with Altered Gut Microbiome Composition

Paternal Programming of Liver Function and Lipid Profile Induced by a Paternal Pre-Conceptional Unhealthy Diet: Potential Association with Altered Gut Microbiome Composition

Consequences of dietary methyl donor supplements: Is more always better?

Bagaimana Gizi Sejak Massa Konsepsi Dapat Mempengaruhi Kesehatan Biologis Anak?

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