Effect of male body mass index on assisted reproduction treatment outcome: an updated systematic review and meta-analysis

Mushtaq, Rabia; Pundir, Jyotsna; Achilli, Chiara; Naji, O.; Khalaf, Yacoub; El‐Toukhy, Tarek

doi:10.1016/j.rbmo.2018.01.002

Cited by 78 publications

(50 citation statements)

References 35 publications

(147 reference statements)

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“…In the present study, the ages of females in the H group and L group were similar, excluding the influence of female age for further analysis in the present study. In addition to age, the factors that have been reported to potentially affect the quality of eggs or embryos were similar in the two groups, including BMI of the female or male, age of the male and DFI of semen [26][27][28][29] . Furthermore, the percentage of IVF cycles, primary infertility and infertility duration were comparable between the two groups.…”

Section: Discussionmentioning

confidence: 88%

AMH has no role in predicting oocyte quality in women with advanced age undergoing IVF/ICSI cycles

Dai

Wang

Yang

et al. 2020

Sci Rep

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It has been widely acknowledged that anti-Müllerian hormone (AMH) is a golden marker of ovarian reserve. Declined ovarian reserve (DOR), based on experience from reproductive-aged women, refers to both the quantitative and qualitative reduction in oocytes. This view is challenged by a recent study clearly showing that the quality of oocytes is similar in young women undergoing IVF cycles irrespective of the level of AMH. However, it remains elusive whether AMH indicates oocyte quality in women with advanced age (WAA). The aim of this study was to investigate this issue. In the present study, we retrospectively analysed the data generated from a total of 492 IVF/ICSI cycles (from January 2017 to July 2020), and these IVF/ICSI cycles contributed 292 embryo transfer (ET) cycles (from June 2017 to September 2019, data of day 3 ET were included for analysis) in our reproductive centre. Based on the level of AMH, all patients (= > 37 years old) were divided into 2 groups: the AMH high (H) group and the AMH low (L) group. The parameters of in vitro embryo development and clinical outcomes were compared between the two groups. The results showed that women in the L group experienced severe DOR, as demonstrated by a higher rate of primary diagnosis of DOR, lower antral follicle count (AFC), higher level of basal follicle stimulating hormone (FSH) and cancelation cycles, lower level of E2 production on the day of surge, and fewer oocytes and MII oocytes retrieved. Compared with women in the H group, women in the L group showed slightly reduced top embryo formation rate but a similar normal fertilization rate and blastocyst formation rate. More importantly, we found that the rates of implantation, spontaneous miscarriage and livebirth were similar between the two groups, while the pregnancy rate was significantly reduced in the L group compared with the H group. Further analysis indicated that the higher pregnancy rate of women in the H group may be due to more top embryos transferred per cycle. Due to an extremely low implantation potential for transfer of non-top embryos from WAA (= > 37 years old) in our reproductive centre, we assumed that all the embryos that implanted may result from the transfer of top embryos. Based on this observation, we found that the ratio of embryos that successfully implanted or eventually led to a livebirth to top embryos transferred was similar between the H and the L groups. Furthermore, women with clinical pregnancy or livebirth in the H or L group did not show a higher level of serum AMH but were younger than women with non-pregnancy or non-livebirth. Taken together, this study showed that AMH had a limited role in predicting in vitro embryo developmental potential and had no role in predicting the in vivo embryo developmental potential, suggesting that in WAA, AMH should not be used as a marker of oocyte quality. This study supports the view that the accumulation of top embryos via multiple oocyte retrieval times is a good strategy for the treatment of WAA.

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Section: Discussionmentioning

confidence: 88%

AMH has no role in predicting oocyte quality in women with advanced age undergoing IVF/ICSI cycles

Dai

Wang

Yang

et al. 2020

Sci Rep

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“…Two recent meta‐analyses have linked human male obesity to reduced rates of clinical pregnancy and live births following ART, while a third found no evidence for a relationship between male BMI and treatment outcomes of ART . Negative effects of male obesity on embryo development have been detected in both human ART cohort studies and animal high‐fat diet studies, indicating that sperm can transmit detrimental factors to offspring that impair development .…”

Section: Discussionmentioning

confidence: 99%

“…For example, some studies find reduced embryo development and clinical pregnancy rates following assisted reproductive treatments (ART) with sperm from males with a BMI greater than 25, but other studies have found no evidence that male BMI influences post fertilization ART outcomes or pregnancy and perinatal outcomes . Moreover, two recent meta‐analyses concluded that rates of clinical pregnancy and live births following ART are reduced when the male is overweight or obese, while another meta‐analysis concluded that increased male BMI does not influence outcomes of assisted reproduction …”

Section: Introductionmentioning

confidence: 99%

High‐fat diets reduce male reproductive success in animal models: A systematic review and meta‐analysis

Crean

Senior

2019

Obesity Reviews

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Sperm counts have shown a progressive decline across the world since the mid-1900s. Global rates of obesity have been climbing at a similarly alarming rate, suggesting that these two factors may be linked. However, studies examining the relationship between body mass index (BMI) and male fertility have produced conflicting results.These discrepancies among studies are commonly attributed to limitations that are inherent in human studies such as correlational data and confounding factors-limitations that are absent from animal studies. Hence, we conducted a systematic review and meta-analysis of animal studies that experimentally induced obesity with a high-fat diet and measured impacts on sperm traits and/or male fertility. Overall, we found strong, consistent evidence in animal studies that high-fat diets are detrimental for male fertility. Compared with controls, males fed a high-fat diet had smaller testes and sex accessory glands relative to body size, reduced semen quality, reduced mating success, and reduced fertilization success. This is the first time that experimental data of high-fat diet effects on male reproduction have been synthesized in a metaanalysis, and thus, our results provide novel insight to the complex question of how dietary-induced obesity affects male fertility. The strong negative effects detected in animal models suggest that the inconsistent results plaguing human studies are an artefact of limitations inherent in correlational studies rather than a true effect.

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“…However, one study revealed that AM could not predict male semen quality [50]. A recent meta-analysis demonstrated that increasing male BMI was associated with a significant reduction in clinical pregnancy rate and live birth rate in IVF cycles [16].…”

Section: Discussionmentioning

confidence: 99%

“…The WC, WHR, and WHtR have also been used for the assessment of obesity, which is a gradually predominant health condition in modern society [9]. The negative associations between obesity and male and female fertility are well documented [10][11][12][13][14][15][16]. However, the majority of previous studies have used the BMI to estimate overall adiposity, without taking body fat distribution into account.…”

Section: Introductionmentioning

confidence: 99%

Association between parental anthropometric measures and the outcomes of intracytoplasmic sperm injection cycles

Setti

Halpern

Braga

et al. 2018

J Assist Reprod Genet

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Purpose To study the association between body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR), and response to controlled ovarian stimulation, semen quality, and intracytoplasmic sperm injection (ICSI) outcomes. Methods This prospective observational study included data from 402 couples undergoing ICSI between January/2010-September/2016. Participants had their weight, height, waist, and hip measured before ICSI treatment. Results Gonadotropin dose was positively associated with maternal WHR. Maternal WC and WHR negatively influenced the estradiol level, number of follicles, oocytes, and mature oocytes. Maternal BMI negatively influenced oocyte yield. Semen volume was negatively influenced by male BMI. Sperm concentration was negatively associated with WHR and WHtR. Progressive sperm motility was negatively influenced by all anthropometric measures (AMs). The TMSC was negatively affected by all AM but WC. Significant differences were observed in all ICSI outcomes except pregnancy and miscarriage rates, favoring women with AM below the cut off values compared to women above the cut off. It was observed that men with AM below the cut off values showed significantly higher rates of fertilization, embryo and blastocyst development, implantation, and pregnancy than men above the cut off. When combined maternal and paternal AM were analyzed, significant differences were observed in fertilization, embryo and blastocyst development and implantation rates, favoring couples with normal BMI, WC, and WHR. Conclusions Lower AMs have a protective effect on fertility. Awareness and counseling on how to minimize its impact in both partners could improve ICSI outcomes.

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Effect of male body mass index on assisted reproduction treatment outcome: an updated systematic review and meta-analysis

Cited by 78 publications

References 35 publications

AMH has no role in predicting oocyte quality in women with advanced age undergoing IVF/ICSI cycles

AMH has no role in predicting oocyte quality in women with advanced age undergoing IVF/ICSI cycles

High‐fat diets reduce male reproductive success in animal models: A systematic review and meta‐analysis

Association between parental anthropometric measures and the outcomes of intracytoplasmic sperm injection cycles

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