Effect of male age on fertility: evidence for the decline in male fertility with increasing age

The effects of advanced paternal age on fertility

“…47 Moreover, when compared with men ,25 years old, men of APA (.45 years) were 4.6 times more likely not to induce pregnancy until after 1 year of regular unprotected intercourse. When those men who took longer than 2 years to induce a pregnancy with their partners were examined, men of APA (.45 years) were 12.5 times more likely to be included.…”

“…When those men who took longer than 2 years to induce a pregnancy with their partners were examined, men of APA (.45 years) were 12.5 times more likely to be included. 47 Interestingly, the effects of APA were not dependent on female age, suggesting that males alone contributed to this effect. 3,47 Other studies demonstrated similar effects.…”

“…47 Interestingly, the effects of APA were not dependent on female age, suggesting that males alone contributed to this effect. 3,47 Other studies demonstrated similar effects. For example, a prospective study from Europe examining 782 couples (women aged 18-40) who achieved pregnancy by intercourse alone, reported that when women reached their late thirties, male age became a significant factor in achieving pregnancy.…”

“…6 Indeed, paternal information is often missing from the birth certificate and the age of the father is not reported in 14% of all births. 6 In those cases where the paternal age was reported, the rates of live births per 1000 men increased from 6.1 in 1980 to 8.2 in 2007 among men aged [45][46][47][48][49] years. 6 These statistics are mirrored in advanced countries around the world.…”

Potential Risk of Senescence on Male fertility and Sperm DNA damage on Progeny

“…We earlier reported lower levels of total antioxidant capacity in infertile than control male subjects [49] . The increased generation of ROS often observed in older men [37][38][39], may be due to several factors and include routine medical prescription and environmental pollutants [58]. The generation of ROS could be made worse by infection, prolonged stasis and abnormal spermatozoa, environmental and life style changes [44,45,[59][60][61] .…”