Effect of magnesium supplementation on the fractional intestinal absorption of 45CaCl2 in women with a low erythrocyte magnesium concentration

Basso, Luisa E.; Ubbink, Johan B.; Delport, Rhena; Spies, J. H.; Vermaak, W. J. H.

doi:10.1053/meta.2000.7711

Cited by 5 publications

(5 citation statements)

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“…An increase in Mg bioavailability might have been detected from measurements of intracellular Mg. Large Mg supplements (250 mg=day for 4 weeks) produce modest PTH and bone resorption effects of milk JH Green et al increases in erythrocyte Mg concentration (Doyle et al, 1999). However, a daily supplement of an amount of Mg that was similar to the one we used (125 mg=day), provided as Mg citrate malate for 3 weeks has been shown to have no impact on intracellular erythrocyte concentration (Basso et al, 2000).…”

Section: Discussionmentioning

confidence: 85%

“…Serum PTH and biochemical markers of bone turnover have been shown to be transiently reduced during the first 5 -10 days of 30 days of Mg supplementation in young men (Dimai et al, 1998). However, Mg supplementation for longer than 2 weeks does not lead to significant changes in bone resorption markers or serum PTH (Dimai et al, 1998;Doyle et al, 1999;Basso et al, 2000). We have previously observed decreases in bone resorption in response to 4 weeks of supplementary Mg-enriched high Ca milk that were greater than those seen for high Ca milk without additional Mg (Green et al, 2000), but that study did not include any measurements of serum PTH, Ca or Mg.…”

Section: Introductionmentioning

confidence: 99%

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Acute effect of high-calcium milk with or without additional magnesium, or calcium phosphate on parathyroid hormone and biochemical markers of bone resorption

2003

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Objective: To assess whether there are any differences in the postprandial physiological responses to apple drink (control), calcium phosphate (tricalcium phosphate, TCP) and high-calcium skim milk (HCSM) with or without additional magnesium in postmenopausal women. Design: Randomized, controlled, cross-over. Measurements after overnight fast before each drink, and subsequently every hour for 8 h postprandially. Results: There was no difference in baseline serum calcium, PTH or C-telopeptide levels between drinks. There were no overall differences in serum calcium after apple or after either milk, but after TCP serum calcium increased from a baseline value of 2.12 AE 0.08 to a mean peak of 2.21 AE 0.12 mmol=l (s.d.) (P ¼ 0.0001) after 2 h. There were no significant differences in serum PTH after either apple or HCSM þ Mg. In contrast, after TCP, serum PTH decreased from 2.76 AE 0.69 to a mean nadir of 2.23 AE 0.65 pmol=l (P ¼ 0.0001) after 1 h, and after HCSM, it decreased from 2.71 AE 0.78 to a mean nadir of 2.51 AE 0.87 pmol=l (P ¼ 0.007) after 2 h. Serum C-telopeptides decreased after each drink, reaching nadirs after 5 h. At this time the serum values for each of the high calcium drinks were not different from each other, but were significantly less than for apple (P ¼ 0.001 for each), being 0.22 AE 0.09 ng=ml for apple, 0.15 AE 0.08 for TCP, 0.14 AE 0.07 for HCSM and 0.16 AE 0.07 for HCSM þ Mg. Conclusion: Despite differences in serum calcium and PTH responses to the three high-calcium drinks that we tested, there was no distinguishable difference in serum C-telopeptides between high calcium drinks.

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Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Acute effect of high-calcium milk with or without additional magnesium, or calcium phosphate on parathyroid hormone and biochemical markers of bone resorption

2003

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“…More recently, a randomized trial of magnesium supplementation, conducted in Ireland, found that increasing magnesium intake from 11 mmol/d (264 mg/d) to ∼22 mmol/d (528 mg/d) for 28 d did not increase urinary excretion of calcium among women aged 20–28 y ( 106 ). Another randomized trial conducted in women aged ∼40 y in South Africa also found that magnesium supplementation at 250 mg/d (10.3 mmol/d) did not change urinary excretion of calcium, but it reduced fractional absorption of calcium by 23.5%, which was not caused by direct competition between the 2 minerals ( 107 ). However, a third trial conducted in men aged 21–42 y in Japan found that supplementation of 250 mg magnesium (as MgO) significantly elevated the urinary excretion of calcium ( 108 ).…”

Section: Calciummentioning

confidence: 98%

Essential Nutrient Interactions: Does Low or Suboptimal Magnesium Status Interact with Vitamin D and/or Calcium Status?

Rosanoff¹,

Dai

Shapses

2016

Advances in Nutrition

109

105

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Although much is known about magnesium, its interactions with calcium and vitamin D are less well studied. Magnesium intake is low in populations who consume modern processed-food diets. Low magnesium intake is associated with chronic diseases of global concern [e.g., cardiovascular disease (CVD), type 2 diabetes, metabolic syndrome, and skeletal disorders], as is low vitamin D status. No simple, reliable biomarker for whole-body magnesium status is currently available, which makes clinical assessment and interpretation of human magnesium research difficult. Between 1977 and 2012, US calcium intakes increased at a rate 2–2.5 times that of magnesium intakes, resulting in a dietary calcium to magnesium intake ratio of >3.0. Calcium to magnesium ratios <1.7 and >2.8 can be detrimental, and optimal ratios may be ∼2.0. Background calcium to magnesium ratios can affect studies of either mineral alone. For example, US studies (background Ca:Mg >3.0) showed benefits of high dietary or supplemental magnesium for CVD, whereas similar Chinese studies (background Ca:Mg <1.7) showed increased risks of CVD. Oral vitamin D is widely recommended in US age-sex groups with low dietary magnesium. Magnesium is a cofactor for vitamin D biosynthesis, transport, and activation; and vitamin D and magnesium studies both showed associations with several of the same chronic diseases. Research on possible magnesium and vitamin D interactions in these human diseases is currently rare. Increasing calcium to magnesium intake ratios, coupled with calcium and vitamin D supplementation coincident with suboptimal magnesium intakes, may have unknown health implications. Interactions of low magnesium status with calcium and vitamin D, especially during supplementation, require further study.

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“…It is unlikely that the additional magnesium in the product that we tested had any impact on bone resorption. Magnesium supplementation transiently decreases both serum PTH and biochemical markers of bone turnover in young people during the first 5−10 days of 30 days of magnesium supplementation, but is no longer evident after 2 weeks 19−21 . We have recently reported no difference in the postprandial PTH and bone resorption responses to either high calcium skim milk or high calcium skim milk enriched with magnesium 18 …”

Section: Discussionmentioning

confidence: 90%

Impact of supplementary high calcium milk with additional magnesium on parathyroid hormone and biochemical markers of bone turnover in postmenopausal women

Green

Booth

Bunning

2002

Asia Pac J Clin Nutr

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The aim of this study was to investigate the impact of magnesium-enriched, high-calcium milk on serum parathyroid hormone (PTH) and biochemical markers of bone turnover in postmenopausal women. We recruited 50 healthy postmenopausal women to take part in this randomised controlled study. Half of the women consumed two serves of high-calcium skim milk enriched with magnesium (milk group) and half consumed two serves apple drink per day (apple group), each for 4 weeks. The milk provided 1200 mg calcium and an additional 106 mg magnesium. We investigated the responses of serum PTH, as well as the serum and urinary calcium, magnesium and biochemical markers of bone turnover. There was no effect of time or drink on the clinical biochemistry, serum PTH or urine markers of bone resorption (free deoxypyridinoline and N-telopeptides). Serum C-telopeptides (CTX), another marker of bone resorption, did not change with time in the apple group. However, in the milk group, serum CTX deceased significantly from 0.43 +/- 0.04 ng/mL to 0.32 +/- 0.02 at 2 weeks (p < 0.0001) and 0.28 +/- 0.02 at 4 weeks (p < 0.0001). In the milk group, urinary calcium and magnesium each increased during the night but not during the day. Overall, these data suggest that milk has an antiresorptive effect on bone, but that this is not accompanied by measurable changes in serum PTH.

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Effect of magnesium supplementation on the fractional intestinal absorption of 45CaCl2 in women with a low erythrocyte magnesium concentration

Cited by 5 publications

References 20 publications

Acute effect of high-calcium milk with or without additional magnesium, or calcium phosphate on parathyroid hormone and biochemical markers of bone resorption

Acute effect of high-calcium milk with or without additional magnesium, or calcium phosphate on parathyroid hormone and biochemical markers of bone resorption

Essential Nutrient Interactions: Does Low or Suboptimal Magnesium Status Interact with Vitamin D and/or Calcium Status?

Impact of supplementary high calcium milk with additional magnesium on parathyroid hormone and biochemical markers of bone turnover in postmenopausal women

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