Effect of &lt;i&gt;Panax ginseng&lt;/i&gt; on Carbamazepine Pharmacokinetics in Rabbits

Abushammala, Issam; Ali, Fatma Khaled El-Shaikh; Shammaleh, Kamal Fakher Abu; Taha, Mohammed; Miqdad, Mohammed Yousef

doi:10.4274/tjps.galenos.2019.24993

Cited by 2 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pharmacokinetic study in rats indicated that Rhizoma Gastrodiae could reduce the auto-induction of CBZ and increase the plasma concentration of CBZ and its metabolite, demonstrating an herb-drug interaction of Rhizoma Gastrodiae with CBZ which will provide implications for epilepsy treatment in clinic ( 98 ). On the contrary, Panax ginseng was reported to unlikely interfere with the pharmacokinetic of CBZ in rabbits ( 100 ). The complicated herb-drug interactions indicated that additional caution should be taken when combination treatment with TCM and AEDs are performed.…”

Section: Discussionmentioning

confidence: 99%

A narrative review on traditional Chinese medicine prescriptions and bioactive components in epilepsy treatment

Feng¹,

Cai²,

Deng³

et al. 2023

Ann Transl Med

View full text Add to dashboard Cite

Background and Objective: In traditional Chinese medicine (TCM), natural drugs and their bioactive components have been widely used to treat epilepsy. Epilepsy is a chronic disease caused by abnormal discharge of brain neurons that leads to brain dysfunction and cognitive impairment. Several factors are involved in the mechanisms of epilepsy, and the current treatments do not seem promising. The potential efficacy of natural drugs with lower toxicity and less side effects have attracted increasing attention.Methods: We used the terms, "TCM", "traditional Chinese medicine", "herbal", "epilepsy", "seizure", and the name of each prescription and bioactive components in the review to collect papers about application of TCM in epilepsy treatment from PubMed online database and Chinese database including Chinese National Knowledge Infrastructure (CNKI), Wanfang, and Weipu.

show abstract

Section: Discussionmentioning

confidence: 99%

A narrative review on traditional Chinese medicine prescriptions and bioactive components in epilepsy treatment

Feng¹,

Cai²,

Deng³

et al. 2023

Ann Transl Med

View full text Add to dashboard Cite

show abstract

Herb-Drug Interactions and Their Impact on Pharmacokinetics: An Update

Cheng

Xia

et al. 2023

CDM

View full text Add to dashboard Cite

Herb medicine has a long history of application and is still used worldwide. With the development of complementary and alternative medicine, the interaction between herb and drugs has attracted more and more attention. Herb-drug interactions (HDI) could cause decreased efficiency, increased toxicity, and affect the drug absorption and disposition processes due to the interference of their pharmacological or pharmacokinetic effects. Hence, the mechanisms and results of herb-pharmacokinetic interactions should be comprehensively summarized. Here, we have summarized the mechanisms of HDI and pharmacokinetic interactions in the last ten years based on searching on PubMed, Science Direct, and Web of Science with different keywords. Besides, the pharmacokinetic interactions were related to nine commonly used herbs and drugs, including Ginseng, Salvia miltiorrhiza, Ginkgo biloba, Garlic, Coptis chinensis, St. John's wort, Ginger, Licorice, Silythistle and Fructus Schisandrae. This review provides an overview of HDI to provide a reference for the rational and safe clinical use of herbs and drugs.

show abstract

Effect of <i>Panax ginseng</i> on Carbamazepine Pharmacokinetics in Rabbits

Cited by 2 publications

References 17 publications

A narrative review on traditional Chinese medicine prescriptions and bioactive components in epilepsy treatment

A narrative review on traditional Chinese medicine prescriptions and bioactive components in epilepsy treatment

Herb-Drug Interactions and Their Impact on Pharmacokinetics: An Update

Contact Info

Product

Resources

About