EFFECT OF &lt;i&gt;CATHA EDULIS&lt;/i&gt; ON INSULIN, RESISTIN AND CORTISOL LEVELS IN TYPE-2 DIABETICS AND NON-DIABETICS

El-sayed, Mohamed I Kotb; Amin, Hatem K.

doi:10.3844/ajbbsp.2012.157.163

Cited by 13 publications

(2 citation statements)

References 45 publications

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“…Additionally, cathinone reduces the activity of enzymes that metabolize free radicals, intensifying oxidative stress, which is a critical factor in the onset of diabetes and its complications. 38,39 In this study, people with a history of khat chewing were 2.32 times more likely to have DPN compared to non-chewers. This finding is comparable with a meta-analysis and cross-sectional studies done in Saudi Arabia and Yemen.…”

Section: Discussionmentioning

confidence: 64%

Diabetic peripheral neuropathy and their associations with overweight/obesity and impaired blood glucose among diabetic patients in Eastern Ethiopia: Institutional-based study

Fentie,

Solomon,

Abebe

et al. 2023

SAGE Open Medicine

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Objective: This study aimed to determine the burden of diabetic peripheral neuropathy and its associations with overweight/obesity and impaired blood glucose among diabetic patients in Eastern Ethiopia. Method: A total of 644 diabetic individuals were included in the study through systematic random sampling techniques. The Michigan neuropathy screening instrument was used to evaluate the presence of diabetic neuropathy. Data were presented using narrative, figures, and tables from the results of statistical analysis. The descriptive result was reported using frequency (percentage) for categorical variables and mean ± SD for continuous measures, respectively. Multivariable logistic regression was performed to identify factors associated with diabetic peripheral neuropathy. Results: The overall prevalence of diabetic peripheral neuropathy was 47.8% (95% CI: 43.9%–51.7%). Low monthly income (AOR: 2.02, 95% CI: 1.09, 3.73), history of khat chewing (AOR: 2.32, 95% CI: 1.04, 4.907), impaired blood glucose (AOR: 1.52, 95% CI: 1.63, 1.94), physical inactivity (AOR: 2.76, 95% CI: 1.74, 4.36), and raised body mass index (AOR: 2.45, 95% CI: 1.01, 4.99) were factors significantly associated with diabetic peripheral neuropathy. Conclusion: The study emphasizes the value of early diabetic peripheral neuropathy detection and the widespread presence of diabetic peripheral neuropathy risk factors in diabetes patients. Any initiative intended to lessen the burden of diabetic peripheral neuropathy-related morbidity and high health care costs must be implemented as a strategy.

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Section: Discussionmentioning

confidence: 64%

Diabetic peripheral neuropathy and their associations with overweight/obesity and impaired blood glucose among diabetic patients in Eastern Ethiopia: Institutional-based study

Fentie,

Solomon,

Abebe

et al. 2023

SAGE Open Medicine

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“…Reduced calcium concentration was reported in subjects with depression (41) and depression was more common subjects administered with khat (10 & 42). However, another study indicated that the serum calcium level was significantly increased among normal subjects and diabetic patients who chewed khat (43).…”

Section: Discussionmentioning

confidence: 99%

Effects ofCatha Edulis Forskon Spatial Cognition and correlation with serum electrolytes in Wild- type Male White Albino Rats

Limenie

Dugul

Makonnen

2021

Preprint

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Background : The burdens of psychostimulant use disorders are becoming a worldwide problem. One of the psychostimulants widely consumed in Ethiopia and East African countries is Catha edulis Forsk (khat). However, no studies have been conducted on the cognitive effects of khat and its correlation with serum electrolytes. The present study was aimed to evaluate the effects of khat on cognitive functions and its correlation with serum electrolytes. Materials and Methods — A total of 36 adult (7-8 weeks) wild-type male Swiss albino rats weighing between 213 and 229g were used in this study. The rats were received crude khat extract subchronically (kesc) (100 mg/kg, 200 mg/kg and 300 mg/kg b.w), khat juice (khJ 2.5 mL/kg) and 2% tween 80 in distilled water (T80W- v/v, vehicle) and khat extract subacutely (kesa) (300 mg/kg). Spatial learning and memory were measured using Morris water maze model and serum electrolytes were measured using Cobas 6000. The data were analyzed using SPSS version 21.0 and Microsoft Excel. Results : Spatial learning was improved with trials across the groups, while average escape latency (s) and swim path-length (cm) of rats that received kesc 200 mg/kg (p<0.001 and p<0.001) and kesc 300 mg/kg (p<0.01 and p<0.001) was significantly greater than rats that received the vehicle. However, there was no significant difference in the latency between rats that received kesa 300mg/kg and vehicle (p>0.05). Thigmotaxis was significantly higher in rats that received all doses of khat extract (p<0.001). The time spent in the target quadrant in rats that received kesc 300 mg/kg was significantly reduced (p<0.05). Serum calcium level was inversely correlated with the escape latency (R=-0.417, p<0.05) in rats that received khat. Conclusions : khat extract and juice administered subchronically, but not subacute administration, impaired learning and memory in rats and was associated with serum calcium reduction. The neuronal basis for such alteration should be investigated.

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Pharmacological and Toxicological Effects of Catha edulis F. (Khat)

Engidawork

2017

Phytotherapy Research

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Khat chewing is deeply rooted in the culture and tradition of communities in khat belt countries, and its consumption is spread to other countries through the suitcase trade. The aim of this article is to review current knowledge on the chemistry, social, pharmacology and toxicology of khat and its use. Khat produces effect invariably in every system, which is harmful or beneficial in some instances. Harmful effects are observed in heavy users, although firm evidence is lacking. Chewing khat acutely elicits states of euphoria, which is followed by low mood. Khat contains alkaloids with psychostimulant properties, but the effect cannot be totally explained by these alkaloids. It is also not clear whether the effect produced in some organs like liver could be attributed to khat or pesticides sprayed during farming. Although the evidence indicates that khat has adverse effects in most organs, our understanding of the complex interaction between use and effect is incomplete, and causal relationships have not yet been described. Moreover, khat has positioned itself well in the social, economic and political arena. Thus, a multidisciplinary research is required to understand the different dimensions and come up with ways that maximize the benefit while minimizing the risk. Copyright © 2017 John Wiley & Sons, Ltd.

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EFFECT OF <i>CATHA EDULIS</i> ON INSULIN, RESISTIN AND CORTISOL LEVELS IN TYPE-2 DIABETICS AND NON-DIABETICS

Cited by 13 publications

References 45 publications

Diabetic peripheral neuropathy and their associations with overweight/obesity and impaired blood glucose among diabetic patients in Eastern Ethiopia: Institutional-based study

Diabetic peripheral neuropathy and their associations with overweight/obesity and impaired blood glucose among diabetic patients in Eastern Ethiopia: Institutional-based study

Effects ofCatha Edulis Forskon Spatial Cognition and correlation with serum electrolytes in Wild- type Male White Albino Rats

Pharmacological and Toxicological Effects of Catha edulis F. (Khat)

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