Effect of low-level laser therapy on patient reported measures of oral mucositis and quality of life in head and neck cancer patients receiving chemoradiotherapy—a randomized controlled trial

Gautam, Ajay Prashad; Fernandes, Donald J; Vidyasagar, M S; Maiya, Arun G.; Nigudgi, Shantling

doi:10.1007/s00520-012-1684-4

Cited by 92 publications

(93 citation statements)

References 28 publications

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“…These side effects and toxicities can alter all aspects of oral and oropharyngeal functions affecting diet (taste, dry mouth, chewing, and swallowing) and therefore nutrition. Furthermore, speech, ability to maintain oral hygiene, wearing dental prostheses, and appearance may negatively influence oral health, social, and emotional wellness [2,[19][20][21][22]. These side effects may also affect the ability to deliver cancer therapy as planned and thus, systemic health, outcomes of cancer therapy, and the cost of care [2,5,9,20,[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40].…”

Section: Oral Complications Of Cancer Therapymentioning

confidence: 99%

“…With timely and effective care of acute oral complications, completion of planned cancer treatment protocols can be supported for best outcomes, including improved cure rates [5,14,22,24,27,29]. Unfortunately, cancer patients often have suboptimal oral health prior to cancer diagnosis [9,[54][55][56] and, therefore, are at increased risk for odontogenic (potentially life-threatening) infections during cytotoxic therapy.…”

Section: Oral Care Principlesmentioning

confidence: 99%

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Appropriate and necessary oral care for people with cancer: guidance to obtain the right oral and dental care at the right time

Epstein

Güneri

Barasch

2014

Support Care Cancer

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Purpose The identification of experienced and knowledgeable dental specialists to provide appropriate oral care for cancer patients, as well as the integration of this care within general oncology management, may be a challenge. This paper discusses the general and additional requirements for dental care providers to support the cancer patient and provide prevention and/or treatment for oral complications of cancer therapy. Methods We performed a literature review of specific issues regarding the oral cavity and adjacent structures in the cancer patient, including detection and early diagnosis of oral malignancy. We incorporated the systemic effects of cancer and its therapy that affect oral disease and treatment. We present a summary of how to seek expert dental care for cancer patients and for referral from the dental and medical community. Results Due to the complexity conferred by the disease and its treatment, cancer patients require educated, experienced dentists for treatment and/or prevention of oral-related morbidity. Correct diagnosis and evidence-based prophylactic and therapeutic oral care can significantly improve patient quality of life and reduce morbidity and healthcare costs. Conclusions The knowledge and expertise of dental professionals regarding prevention/treatment of complications and secondary malignant lesions in cancer patients are critical. Integration of oral care with the oncology care and in survivors requires effective communication between dental and medical providers beginning ideally at diagnosis. These clinicians may be identified at the cancer center, nearby hospital dental programs, and, less commonly, in the community.

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Section: Oral Complications Of Cancer Therapymentioning

confidence: 99%

Section: Oral Care Principlesmentioning

confidence: 99%

Appropriate and necessary oral care for people with cancer: guidance to obtain the right oral and dental care at the right time

Epstein

Güneri

Barasch

2014

Support Care Cancer

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“…Recently, there were created 2 meta-analysis consisting guidelines for dosing and preferred parameters of laser radiation. Gautam et al [34], as a result of their meta-analysis study, made a new recommendation for the use of LLLT as a prevention of mucositis in adult patients receiving hematopoietic stem cell transplantation conditioned with high-dose chemotherapy, with or without total body irradiation. Authors suggest that those kinds of patients should receive laser radiation with a wavelength at 650 nm, power of 40 mW and energy density 2 J/cm 2 .…”

Section: Lllt In Dentistrymentioning

confidence: 99%

The Use of Low-Level Energy Laser Radiation in Basic and Clinical Research

Rola¹,

Doroszko²,

Derkacz³

2014

Adv Clin Exp Med

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Laser radiation has specific attributes: monochromaticity, high coherence and polarization. These properties result in the extensive use of lasers in medicine. Laser devices can be assigned into three basic groups by means of their level of energy: high, medium and low energy. All of these types of radiation are used in medicine. However, the most commonly used, in basic science and clinical studies, is low-energy radiation. Molecular effects of low energy laser irradiation on cells are generally described as "fotobiostimulation" and "fotobiomodulation". These phenomena consequently lead to attempts to exploit this kind of radiation as a treatment method (low-level laser therapy-LLLT). Areas in which LLLT is used are: regenerative medicine (for healing wounds and ulcers); aesthetic medicine (to improve appearance of scars); dentistry (to accelerate healing of implants); physiotherapy (to reduce chronic pain syndromes), orthopedics (in bone healing) and cardiology (as a prevention of restenosis after percutaneous coronary intervention). This paper discusses the medical applications of LLLT which are used in daily clinical practice as well as those The laser was invented by Theodor Maiman in 1960 and since that time it is used in many different aspects of human life, including medicine. Lasers are distinguished from other light sources by their coherence, polarization and monochromaticity; therefore, they can transmit a wide range of energy.The physical process enabling the laser to function is called stimulated emission (laser is an acronym of light amplification by stimulated emission of radiation). There are many ways to classify laser devices. Lasers can be grouped by gain medium, wavelengths, modes of operation but the most useful way, from a medical point of view, is the division by energy level. And so by the amount of energy transmitted, the sources of laser radiation are divided into 3 basic groups: low, medium and high energy.There are many reports regarding the usefulness of full laser energy spectrum in clinical practice. High-energy radiation causes tissue destruction and therefore it is mainly applied in surgery. It is used for coagulation, cutting tissue, control of bleeding, destruction of tumors etc. Medium energy lasers are mainly used in oncology, especially as a part of photodynamic therapy. The low energy laser, among the all energy radiation groups, seems to have the widest range of applications in medicine. Despite much research, the exact mechanism action of low energy laser radiation on the human body is still unknown. Due to numerous studies on low-energy radiation, new therapeutic applications are being discovered and enrolled to clinical practice. The aim of this paper is to review the most common clinical applications of low-energy lasers.

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“…Por ser uma técnica não invasiva, simples e atraumática, sem relatórios clínicos de toxicidade, a aplicação de luz é ideal para o tratamento de tecidos sem risco de danificar as células saudáveis [30][31][32][33][34][35][36][37][38][39][40][41][42][43] .…”

Section: Revisão Da Literatura Terapia a Laserunclassified

“…Em estudo randomizado, cego, Gautam et al 43 avaliaram 220 pacientes. Houve redução significativa (p <0,001), na incidência de MO grave, da necessidade de analgésicos opioides.…”

Section: Cauwels E Martensunclassified

Efetividade profilática e terapêutica do laser de baixa intensidade na mucosite bucal em pacientes submetidos ao tratamento do câncer

Neto

Westphalen

2014

Rev. da Fac. de Odontologia, UPF

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Objetivo: o objetivo desta revisão de literatura é apresentar os diferentes protocolos clínicos randomizados utilizando o laser de baixa intensidade no manejo da IntroduçãoOs efeitos do laser de baixa intensidade podem levar a uma aceleração no processo de cicatrização de feridas, os quais são atribuídos ao estímulo de diversos processos metabólicos 1 , mediante a conversão da energia luminosa que ele aporta, transformando, por meio de processos bioquímicos e fotofísi-cos, a luz em energia útil para a célula 2 .A conversão fotoquímica é absorvida pelos fotorreceptores celulares, onde a molécula que absorve a luz transfere essa energia para outras moléculas, resultando na ativação celular e em reações quími-cas no tecido circunvizinho. Essa energia celular disponível, envolvendo as mitocôndrias e demais estruturas celulares, provoca o fenômeno de biomodulação celular 3,4 . Apesar desses efeitos, também ocorre um aumento significativo na síntese de proteínas e DNA, modulação da produção dos fatores de crescimento 5 por macrófagos, proliferação de queratinócitos, aumento da população e de granulação de mastócitos e angiogênese 3 , apresentando melhor interação com as fibras de colágeno e enzimas específicas, estimulando a microcirculação local e auxiliando o sistema linfático [6][7][8] . Além de o laser ser bem tolerado pelos pacientes, sua irradiação produz efeitos benéficos, como propriedades anti-inflamahttp://dx

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Effect of low-level laser therapy on patient reported measures of oral mucositis and quality of life in head and neck cancer patients receiving chemoradiotherapy—a randomized controlled trial

Abstract: LLLT was effective in improving the patient's subjective experience of OM and QOL in HNC patients receiving CRT.

Cited by 92 publications

References 28 publications

Appropriate and necessary oral care for people with cancer: guidance to obtain the right oral and dental care at the right time

Appropriate and necessary oral care for people with cancer: guidance to obtain the right oral and dental care at the right time

The Use of Low-Level Energy Laser Radiation in Basic and Clinical Research

Efetividade profilática e terapêutica do laser de baixa intensidade na mucosite bucal em pacientes submetidos ao tratamento do câncer

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