Effect of low-level LASER and neural mobilization on nociceptive threshold in experimental sciatica

Karvat, Jhenifer; Antunes, Juliana Sobral; Bernardino, Giovanni Ribeiro; Kakihata, Camila Mayumi Martin; Bertolini, Gladson Ricardo Flôr

doi:10.5935/1806-0013.20140045

Cited by 9 publications

(7 citation statements)

References 14 publications

(15 reference statements)

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“…The results found by Gonçalves et al 31 showed that therapy with laser application of 830 nm, 4 J/cm² for 14 days contributed to the decrease in the inflammatory process triggered by the compressing injury of the sciatic nerve. 28 This is in accordance with the findings from this study, in a way that an improvement on the TNIG inflammatory process could be observed, as the laser acts as a regulator of the micro medium and provides a nerve regeneration in an effective way. 32 Also, as observed in this study, the presence of integral fibers, presents mostly shorter diameters lengthin the treated groups.…”

Section: Discussionsupporting

confidence: 92%

“…EV2 and EV3 presented a lower nociceptive threshold, which means that there was no improvement on those animals submitted to the DP and treated, while the DP seemed not to have played any influence on this parameter. Similar results were found in the study by Karvat et al, 28 in which, after the compression of the sciatic nerve, LLL treatment of 830 nm 4 J/cm², and neural mobilization, they could draw a significant difference between the EV1 (higher nociceptive threshold) and the others, concluding that the used protocol was not efficient to change the nociceptive threshold.…”

Section: Discussionsupporting

confidence: 89%

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Low-Level Laser Effect on Peripheral Sciatic Regeneration Under the Systemic Inflammatory Condition of Periodontal Disease

et al. 2020

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Introduction: Periodontal disease (PD) is an inflammatory condition, which leads to tooth loss and promotes a systemic inflammatory state that can aggravate the nerve degeneration. As laser therapy may stimulate regeneration, this study aimed to evaluate the effect of the low-level laser (LLL) on peripheral nerve regeneration under the systemic inflammatory condition of PD. Methods: Thirry-two male rats were used, distributed in 4 groups: nerve injury (NIG); periodontal disease with nerve injury (PDNI); nerve injury and treatment (TNIG); periodontal disease with nerve injury and treatment (PDNIT). On the 7th day of the experiment, the animals had ligatures placed around the lower first molars. On the 22nd day, they underwent peripheral nerve damage, and on the 25th day, the LLL treatment was initiated, performed for two weeks. The sciatic functional index (SFI) was evaluated with subsequent euthanasia of all the animals on the 37th day of the experiment. The sciatic nerve was collected for morphological and oxidative stress analysis and the hemi jaws for radiographic analysis. Results: Regarding the SFI, there was no difference among the groups in the first evaluation (EV) pre-injury; as for theEV2, after injury, all the groups presented a decrease in these values, which remained in post-treatment. For the morphology of the PDNI, nerve tissue presented larger diameter fibers, whereas, for NIT and PDNIT, fibers had smaller diameters with endoneurial organization. When it comes to the antioxidant system, there was an increase in protein concentration, higher superoxide activity, and decreased glutathione transferase activity in the treated groups. Catalase and cholinesterase did not differ between the groups, and lipoperoxidation (LPO) increased in the PD groups. For the mandible radiographic analysis, it was possible to verify the induction of PD. Conclusion: As for the used parameters, the low-level laser was not effective in increasing the nociceptive threshold, but it contributed to the regeneration of nerve fibers, although the inflammation was still present in the site. However, the treatment was effective in protecting cells against oxidative damage due to increased SOD and increased protein, although the decrease in GST demonstrates the inhibition of this stage of the antioxidant system.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 89%

Low-Level Laser Effect on Peripheral Sciatic Regeneration Under the Systemic Inflammatory Condition of Periodontal Disease

et al. 2020

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“…The treatment with neural mobilization was performed on the same days of LLLT and the technique was always applied by the same person. 20 The G4 group received both neural mobilization and LLLT therapies, in this order, as described above and always in the right hind limb.…”

Section: Neural Mobilization Protocolmentioning

confidence: 99%

Histological Analysis of Wistar Rats Sciatic Nerves Subjected to Compression and Treated With Low Level Laser Therapy and Neural Mobilization

Antunes

Karvat

Bernardino

et al. 2019

MNJ

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Background: The physical therapy resources, as Low-Level Laser Therapy (LLLT) and neural mobilization are usually used with regenerative purpose and for the relief of symptoms for peripheral nerve injury. However, there is a lack of consensus on its effects as well as its association. Objective: Evaluate the influence of low-level laser therapy (LLLT) associated with neural mobilization (NM) on nerve regeneration of female Wistar rats subjected to sciatic compression. Methods: Twenty four Wistar rats were divided into: G1 (Placebo), G2 (NM), G3 (LLLT) and G4 (NM+LLLT), all animals were subject to compression of the right sciatic nerve. The treatment occurred on the 3 rd , 5 th , 7 th , 10 th , 12 th and 14 th postoperative day (PO). On the 17 th PO the animals were euthanized. Histological and morphometric analysis of the right (compression) and the left (control) sciatic nerve were performed. Results: In the morphometric analysis no significant differences between groups, but differences among sides were found. Histological analysis revealed the presence of inflammatory infiltrate and disruption of nerve fibers in the right sciatic nerves. Conclusion: Both techniques used (LLLT and neural mobilization), isolated and associated, on the parameters proposed, were not effective to accelerate the process of nerve regeneration.

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“…Dessa maneira, para realização do teste no local da lesão, o animal foi contido manualmente e a ponta do filamento foi aplicada perpendicularmente à área da incisão cirúrgica, exercendo-se uma força com aumento gradual, até que o animal retirasse seu membro, e então o teste era interrompido para registro do limiar de retirada. Para facilitar a adaptação dos animais a esse instrumento, nos três dias anteriores à lesão foi realizada a simulação desta avaliação [19].…”

Section: Avaliação Da Nocicepçãounclassified

Efeito do exercício resistido na redução do edema, nocicepção e regeneração nervosa em um modelo de compressão do nervo isquiático

Antunes¹,

Lovison²,

Karvat³

et al. 2016

Sci Med

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Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. ABSTRACT Aims:To analyze the effects of ladder-climbing resistance training exercise on edema, nociception, and regeneration of the sciatic nerve in Wistar rats subjected to sciatic nerve compression. Methods: Twenty-four Wistar rats were divided into four groups: Control Group, Exercise Group, Injury Group, and Treated Group (injury and exercise). Injury Group and Treated Group were subjected to sciatic nerve compression with a hemostat for 30 seconds. On the third day after injury, Exercise Group and Treated Group began treatment with ladder-climbing resistance exercise. The treatment consisted in performing two series of 10 ladder climbs with a 100-gram overload and a one-minute interval between the series. The study was conducted for 22 days, during which time the animals were evaluated for edema and nociception. Twenty-two days after surgery, the animals were anesthetized for removal of a sciatic nerve fragment and analysis of the number of axons and fiber density. Thereafter, still under anesthesia, the animals were euthanized. Nerve sampling followed the routine histological processing protocol. Expressions of Neural Growth Factor and Brain-derived Neurotrophic Factor were evaluated by Western blotting.Results: There was no significant difference in edema size between groups. Control Group showed the highest nociceptive threshold compared to the other groups. The morphometric analysis showed no significant difference in number of axons and fiber density between groups. The expression of Brain-derived Neurotrophic Factor was greater in the Injury Group and the Treated Group compared to the Control Group. Conclusions:The proposed ladder-climbing resistance training was not effective in reducing edema and nociception or in increasing the number of axons and fiber density after sciatic nerve injury.

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Effect of low-level LASER and neural mobilization on nociceptive threshold in experimental sciatica

Cited by 9 publications

References 14 publications

Low-Level Laser Effect on Peripheral Sciatic Regeneration Under the Systemic Inflammatory Condition of Periodontal Disease

Low-Level Laser Effect on Peripheral Sciatic Regeneration Under the Systemic Inflammatory Condition of Periodontal Disease

Histological Analysis of Wistar Rats Sciatic Nerves Subjected to Compression and Treated With Low Level Laser Therapy and Neural Mobilization

Efeito do exercício resistido na redução do edema, nocicepção e regeneração nervosa em um modelo de compressão do nervo isquiático

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