Effect of long-term treatment with hydrochlorothiazide on water and electrolytes of muscle in hypertensive subjects

Villamil, M. F.; Yeyati, N; Enero, María Amelia; Rubianes, C; Taquini, Alberto C.

doi:10.1016/0002-8703(63)90002-4

Cited by 21 publications

(6 citation statements)

References 33 publications

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“…Villamil et al [39] found a significant decrease in total water, sodium and potassium contents in 8 hypertensive subjects treated with hydrochloro thiazide for periods of 22-48 days. Bergstrom and H u ltm a n [4] observed significant changes in water and electrolyte contents of skeletal muscle after a 7-day administration of thiazide diuretics to normal subjects.…”

Section: Discussionmentioning

confidence: 97%

Effects of High Doses of Frusemide on Plasma and Muscle Electrolytes in Patients with Chronic Renal Failure

Maschio¹,

Mioni²,

D’Angelo³

et al. 1974

Nephron

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The effects of high doses of frusemide on plasma and muscle electrolyte composition were investigated in 20 patients with chronic renal failure (CRF), in 5 of them complicated by superimposed cardiac decompensation (CRF + CD). In patients with uncomplicated CRF, short-term frusemide therapy resulted in a decrease of muscle water content, while no significant effect on muscle electrolyte and protein nitrogen contents was observed. On the contrary, in patients with CRF + CD, muscle water (both in the extracellular and intracellular phases), sodium and chloride concentrations fell significantly as a result of frusemide therapy. Muscle potassium remained unchanged, even if related to the cell protein content, in both groups of patients. These results support the conclusion that, in patients with uncomplicated CRF, short-term frusemide therapy acts primarily on plasma and extracellular volume with little or no modification of intracellular fluids and tissue electrolyte composition.

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Section: Discussionmentioning

confidence: 97%

Effects of High Doses of Frusemide on Plasma and Muscle Electrolytes in Patients with Chronic Renal Failure

Maschio¹,

Mioni²,

D’Angelo³

et al. 1974

Nephron

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“…After saluretic therapy with hydrochlorothiazide, 100 mglday, Villamil et al (26) demonstrated a significant decrease in both muscle tissue water and intracellular water, and also in sodium and potassium content in muscle tissue in hypertensive subjects. This agrees with the findings of Bergstrom et al (7), who demonstrated a significant decrease in total and intracellular muscle tissue water after four months of mefruside treatment in eight hypertensive patients.…”

Section: Discussionmentioning

confidence: 99%

Effect of Saluretic Therapy on Muscle Content of Water and Electrolytes in Relation to Hemodynamic Variables

Bevegård

Castenfors

Danielson

et al. 1977

Journal of Internal Medicine

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Muscle content of water and electrolytes (needle biopsy), intraarterial BP and cardiac output (dye dilution technique) were measured in 12 patients with essential hypertension before and after 4 months of mefruside therapy (25 mg/day). Before therapy there were no significant differences in muscle tissue electrolyte and water content compared with normotensive subjects. No correlation was found between central hemodynamic variables and the electrolyte and water content of muscle tissue either before or after therapy. After 4 months of mefruside therapy, muscle tissue water showed a mean decrease which was not significant. Serum potassium and muscle potassium content decreased significantly but there was no significant change in intracellular potassium concentration. Intracellular sodium concentration increased significantly, while muscle sodium content showed a mean increase which was not statistically significant. The change in intracellular sodium concentration showed a significant negative correlation with the decrease in mean arterial BP. The change in total cellular water content showed a significant negative correlation to the changes in total peripheral vascular resistance. Saluretic therapy seems to induce counterregulatory mechanisms that interfere with the hypotensive effect.

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“…From studies in rats, WELLER and HAIGHT (1963) and TALSO et al (1966) found no change in skeletal muscle electrolytes, but others have found some evidence for an increase in tissue sodium and loss of potassium (TOBIAN et al, 1962;WOLF and GESSLER, 1964). In one study, hydrochlorothiazide was reported to reduce total muscle and intracellular water, sodium and potassium content in man (VILLAMIL et al, 1963). In passing it should be noted that thiazides are without effect on tissue ions in nephrectomized animals (ORBISON, 1962).…”

Section: Chronic Haemodynamic Responsementioning

confidence: 99%

Antihypertensive Effect of Diuretics

Conway¹

1977

Antihypertensive Agents

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Effect of long-term treatment with hydrochlorothiazide on water and electrolytes of muscle in hypertensive subjects

Cited by 21 publications

References 33 publications

Effects of High Doses of Frusemide on Plasma and Muscle Electrolytes in Patients with Chronic Renal Failure

Effects of High Doses of Frusemide on Plasma and Muscle Electrolytes in Patients with Chronic Renal Failure

Effect of Saluretic Therapy on Muscle Content of Water and Electrolytes in Relation to Hemodynamic Variables

Antihypertensive Effect of Diuretics

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