Effect of liquid cooling on PCR performance with the parametric study of cross-section shapes of microchannels

Alihosseini, Yousef; Azaddel, Mohammad Reza; Moslemi, Sahel; Mohammadi, Mehdi; Pormohammad, Ali; Targhi, Mohammad Zabetian; Heyhat, Mohammad Mahdi

doi:10.1038/s41598-021-95446-0

Cited by 14 publications

(4 citation statements)

References 34 publications

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“…To provide a more comprehensive analysis of the reasons for the differences in heat transfer performance caused by different cross-sectional shapes. Alihosseini et al [14] numerically simulated 15 microchannels with different cross-sectional shapes and presented the temperature distribution clouds for eight different cross-sectional shapes with better temperature distribution (Fig. 3), where the circular cross-sectional shape has few hot spot areas and uniform temperature distribution.…”

Section: Special-shaped Cross-section Channelmentioning

confidence: 99%

Topological structures for microchannel heat sink applications – a review

Wang

et al. 2023

Manufacturing Rev.

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The microchannel heat sink (MCHS) has the advantages of small heat transfer resistance, high heat transfer efficiency and small size, which exhibits good heat transfer performance in the field of active heat dissipation of electronic devices integrated with high heat flux density. In this paper, the application of MCHS in thermal management is reviewed in recent years, and the research progress of microchannel topology on enhancing heat transfer performance is summarized. Firstly, the research progress on the cross-sectional shape of the microchannel shows that the heat transfer area and fluid flow dead zone of the microchannel is the keys to affecting the heat transfer performance; Secondly, the microchannel distribution and the bionic microchannel structure have a great role in enhancing heat transfer performance, especially in microchannel temperature uniformity; Thirdly, the disturbing effect caused by interrupted structures in microchannels such as ribs and concave cavities has become a hot topic of research because it can weaken the thermal boundary layer and increase heat dissipation. Finally, the commonly used MCHS materials and cooling media are summarized and introduced. Based on the above reviews of MCHS research and applications, the future trends of MCHS topologies are presented.

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Section: Special-shaped Cross-section Channelmentioning

confidence: 99%

Topological structures for microchannel heat sink applications – a review

Wang

et al. 2023

Manufacturing Rev.

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“…Unquestionably, microchannel heat sinks have found applications in numerous studies. For instance, Alihosseini et al [7] proposed a PCR reaction device based on microchannel cooling. The study findings reveal that in such a device, cooling a saliva sample within the PCR wells requires merely 16.5 s, significantly reducing the time for DNA amplification while also occupying minimal space.…”

Section: Introductionmentioning

confidence: 99%

Numerical Simulation and Application of a Channel Heat Sink with Diamond Ribs

Zhang,

Liu,

Lai

et al. 2023

Water

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This paper presents a channel radiator with ribbed ribs and primarily investigates the fluid flow and heat-transfer characteristics of the channel radiator. A three-dimensional numerical simulation of the radiator’s pressure-drop and heat-transfer process was conducted using the finite volume method. A comparison between the experimental data and the simulation results demonstrates that the simulation in this paper is accurate, with a maximum error not exceeding 5%. Furthermore, the radiator was further subjected to geometric parameter studies, principally including the height ratio between the fins and the channel, the fin angle, and the spacing between the fins. The thermal resistance, Nusselt number, friction factor, and heat-transfer enhancement factor were calculated. The results indicate that if the geometric parameters are selected appropriately, the heat sink will enhance heat-transfer performance within an acceptable pressure drop. When the Reynolds number is greater than 507.5, the height ratio of 25%, the rib angle of 135°, and the rib spacing of 2.5 mm can be given priority. This heat sink is used in PCR devices, and experimental results show that the novel channel heat sink can meet the heat dissipation requirements of the TEC during the PCR process.

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“… 2 , 3 , the use of different manifolds shape 4 , 5 , changing shape of channel cross-section 6 , 7 , and changing channel geometry 8 , 9 are among the methods that have been studied in recent years to improve the thermal performance of these systems. Recently, critical researches were performed about the use of nanofluids, and the effect of geometric design on the microchannel heat sinks thermal–hydraulic performance 10 – 13 .…”

Section: Introductionmentioning

confidence: 99%

Investigation of wavy microchannel ability on electronic devices cooling with the case study of choosing the most efficient microchannel pattern

Ghorbani

Targhi

Heyhat

et al. 2022

Sci Rep

Self Cite

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A numerical study was conducted to investigate the ability of wavy microchannels to damp the temperature fluctuations generates in electronic devices. Five wavy patterns are considered with the amplitude and wavelength in the ranges of 62.5 to 250 μm and 1250 to 5000 μm, respectively to study the effect of governing phenomena of flow within wavy patterns on thermal–hydraulic performance. The flow regime is laminar and the Reynolds number is in the range of 300 to 900, and a relatively high heat flux of 80 W/cm2 is applied to the microchannels substrate. Also, variable flux condition is studied for heat fluxes of 80, 120, 160, 200, and 240 W/cm2 and for the most efficient wavy and straight microchannels. Results showed that the geometries with larger amplitude to wavelength ratio have a lower radius of curvature and larger Dean number, and as a result of transverse flow (secondary flow) amplification, they have enhanced heat transfer. Also, by comparing the ratio of the transverse velocity components to the axial component, it was found that by decreasing the radius of curvature and increasing the Dean number, transverse velocity increases, which intensifies the heat transfer between the wall and the fluid. The appraisement of the performance evaluation criterion (PEC) illustrates that the wavy case with an amplitude of 250 μm and wavelength of 2500 μm is the best geometry from the thermal–hydraulic point of view in the studied range. Finally, with variable flux condition, the wavy microchannel has responded well to the temperature increase and has created a much more uniform surface temperature compared to straight pattern. The proposed wavy pattern ensures that there are no hotspots which could damage the electronic chip. Presented wavy patterns can be used in heat sinks heat transfer enhancement to allow the chip to run in higher heat fluxes.

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Effect of liquid cooling on PCR performance with the parametric study of cross-section shapes of microchannels

Cited by 14 publications

References 34 publications

Topological structures for microchannel heat sink applications – a review

Topological structures for microchannel heat sink applications – a review

Numerical Simulation and Application of a Channel Heat Sink with Diamond Ribs

Investigation of wavy microchannel ability on electronic devices cooling with the case study of choosing the most efficient microchannel pattern

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