volume 49, issue 2-3, P375-379 1988
DOI: 10.1016/0300-483x(88)90021-2
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Abstract: The relationship between brain concentration of lindane and its convulsant effect have been studied in rats after repeated low doses of lindane. The mean brain plateau concentration was achieved in 5-8 days. The doses administered (5, 12 and 20 mg/kg) and the brain concentration of lindane at the plateau were highly correlated. The incidence rate of response (percentage of rats with tonic convulsions) was also highly correlated with the log of concentration of lindane in brain for all doses and days studied. A…

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