Effect of LHCGR Gene Polymorphism (rs2293275) on LH Supplementation Protocol Outcomes in Second IVF Cycles: A Retrospective Study

Ga, Ramaraju; Cheemakurthi, Ravikrishna; Madan, K.; Prathigudupu, Kavitha; Balabomma, Kavitha Lakshmi; Mahapatro, Pranati; Thota, Sivanarayana; Kommaraju, Aruna Lakshmi; Muvvala, Sanni Prasada Rao

doi:10.3389/fendo.2021.628169

Cited by 7 publications

(4 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, in the same study, the pregnancy rate was significantly higher in serine carriers who received rFSH/rLH than in those receiving rFSH alone ( 64 ). These data combined with others ( 65 ) suggests a probable benefit of administering LH supplementation to women undergoing IVF on the basis of their single-nucleotide polymorphism profile (rs2293275) of LHCGR.…”

Section: Genetic Variants In Gonadotropins’ Receptors: Pharmacologica...mentioning

confidence: 57%

Luteinizing hormone supplementation in women with hypogonadotropic hypogonadism seeking fertility care: Insights from a narrative review

et al. 2022

View full text Add to dashboard Cite

The management of infertile women affected by hypogonadotropic hypogonadism (HH) or conditions mimicking it is particularly challenging. In the present narrative review, we aimed to synthesize the available evidence on the benefit (if any) of exogenous luteinizing hormone (LH) supplementation in this group of patients. Available data support LH supplementation in women with organic or functional HH. On the contrary, the benefit of exogenous LH on reproductive outcomes both in advanced maternal age patients and in cases of depletion of FSH and LH levels induced by GnRH analogues has not been demonstrated. unfortunately, the inhomogeneous study populations as well as the methodological heterogeneity between studies focused on women affected by conditions mimicking HH do not allow reliable conclusions to be drawn.

show abstract

Section: Genetic Variants In Gonadotropins’ Receptors: Pharmacologica...mentioning

confidence: 57%

Luteinizing hormone supplementation in women with hypogonadotropic hypogonadism seeking fertility care: Insights from a narrative review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…As already stated in this Delphi consensus, there are limited data on the influence of polymorphisms of the LHB/LHCGR genes on ovarian stimulation outcomes and their usefulness in pharmacogenomic research in ART. While the usefulness of polymorphisms in these genes per se remains to be determined, a recent study (also published since the selection of the literature for consideration in this Delphi Consensus) may indicate some clinical value in determining the need for LH supplementation compared with current supplementation protocols, reporting higher clinical pregnancy rates (p=0.049) and a trend towards improved live birth rates (p=0.082) in 193 women when supplementation was based on a woman's SNP profile compared with conventional methods (76). Furthermore, in a cross-sectional study of LHCGR rs2293275 (c.935 A>G, p.Asn312Ser), Lindgren et al reported no significant difference in the number of oocytes retrieved or obvious differences in embryo quality between Ser/Ser, Asn/Ser or Asn/ Asn carriers.…”

Section: Discussionmentioning

confidence: 99%

Effect of Genetic Variants of Gonadotropins and Their Receptors on Ovarian Stimulation Outcomes: A Delphi Consensus

et al. 2022

View full text Add to dashboard Cite

BackgroundA Delphi consensus was conducted to evaluate the influence of single nucleotide polymorphisms (SNPs) in genes encoding gonadotropin and gonadotropin receptors on clinical ovarian stimulation outcomes following assisted reproductive technology (ART) treatment.MethodsNine experts plus two Scientific Coordinators discussed and amended statements plus supporting references proposed by the Scientific Coordinators. The statements were distributed via an online survey to 36 experts, who voted on their level of agreement or disagreement with each statement. Consensus was reached if the proportion of participants agreeing or disagreeing with a statement was >66%.ResultsEleven statements were developed, of which two statements were merged. Overall, eight statements achieved consensus and two statements did not achieve consensus. The statements reaching consensus are summarized here. (1) SNP in the follicle stimulating hormone receptor (FSHR), rs6166 (c.2039A>G, p.Asn680Ser) (N=5 statements): Ser/Ser carriers have higher basal FSH levels than Asn/Asn carriers. Ser/Ser carriers require higher amounts of gonadotropin during ovarian stimulation than Asn/Asn carriers. Ser/Ser carriers produce fewer oocytes during ovarian stimulation than Asn/Asn or Asn/Ser carriers. There is mixed evidence supporting an association between this variant and ovarian hyperstimulation syndrome. (2) SNP of FSHR, rs6165 (c.919G>A, p.Thr307Ala) (N=1 statement): Few studies suggest Thr/Thr carriers require a shorter duration of gonadotropin stimulation than Thr/Ala or Ala/Ala carriers. (3) SNP of FSHR, rs1394205 (−29G>A) (N=1 statement): Limited data in specific ethnic groups suggest that A/A allele carriers may require higher amounts of gonadotropin during ovarian stimulation and produce fewer oocytes than G/G carriers. (4) SNP of FSH β-chain (FSHB), rs10835638 (−211G>T) (N=1 statement): There is contradictory evidence supporting an association between this variant and basal FSH levels or oocyte number. (5) SNPs of luteinizing hormone β-chain (LHB) and LH/choriogonadotropin receptor (LHCGR) genes (N=1 statement): these may influence ovarian stimulation outcomes and could represent potential future targets for pharmacogenomic research in ART, although data are still very limited.ConclusionsThis Delphi consensus provides clinical perspectives from a diverse international group of experts. The consensus supports a link between some variants in gonadotropin/gonadotropin receptor genes and ovarian stimulation outcomes; however, further research is needed to clarify these findings.

show abstract

“…Literature demonstrates the correlation of LHCGR genotype with PCOS, slow response to ovarian stimulation along with relation to FSH consumption and dose of LH required. [ 23 24 25 ] Interestingly, 82% of the patient group had AA genotype which indicates that it could be a strong biomarker for female infertility.…”

Section: Discussionmentioning

confidence: 99%

High-Risk genotypes associated with poor response to controlled ovarian stimulation in Indian women

Udumudi¹,

Lava²,

Hegde³

2023

J Hum Reprod Sci

View full text Add to dashboard Cite

A BSTRACT Background: Infertility is a global burden and has become exceedingly common in the preceding years; controlled ovarian stimulation (COS) is a pre-requisite for couples opting to conceive via in vitro fertilisation (IVF). Based on the number of oocytes retrieved upon COS, a patient may be classified as a good responder or poor responder. The genetic aspect of response to COS has not been elucidated in the Indian population. Aims: This study aimed to establish a genomic basis for COS in IVF in the Indian population and to understand its predictive value. Settings and Design: The patient samples were collected at both Hegde Fertility Centre and GeneTech laboratory. The test was carried out at GeneTech, a diagnostic research laboratory based in Hyderabad, India. Patients with infertility without any history of polycystic ovary syndrome and hypogonadotropic hypogonadism were included in the study. Detailed clinical, medical and family history was obtained from patients. The controls had no history of secondary infertility or pregnancy losses. Materials and Methods: A total of 312 females were included in the study comprising 212 women with infertility and 100 controls. Next-generation sequencing technology was employed to sequence multiple genes associated with response to COS. Statistical Analysis Used: Statistical analysis using odds ratio was carried out to understand the significance of the results obtained. Results: Strong association of c.146G>T of AMH , c.622-6C>T of AMHR2 , c.453-397T>C and c.975G>C of ESR1 , c.2039G>A of FSHR and c.161+4491T>C of LHCGR with infertility and response to COS was established. Further, combined risk analysis was carried out to establish a predictive risk factor for patients with a combination of the genotypes of interest and biochemical parameters commonly considered during IVF procedures. Conclusion: This study has enabled the identification of potential markers pertaining to response to COS in the Indian population.

show abstract

Effect of LHCGR Gene Polymorphism (rs2293275) on LH Supplementation Protocol Outcomes in Second IVF Cycles: A Retrospective Study

Cited by 7 publications

References 37 publications

Luteinizing hormone supplementation in women with hypogonadotropic hypogonadism seeking fertility care: Insights from a narrative review

Luteinizing hormone supplementation in women with hypogonadotropic hypogonadism seeking fertility care: Insights from a narrative review

Effect of Genetic Variants of Gonadotropins and Their Receptors on Ovarian Stimulation Outcomes: A Delphi Consensus

High-Risk genotypes associated with poor response to controlled ovarian stimulation in Indian women

Contact Info

Product

Resources

About