Effect of Levo-Thyroxine Replacement on Non-High-Density Lipoprotein Cholesterol in Hypothyroid Patients

M, Ito; Arishima, Takeshi; Kudo, Takumi; Nishihara, Eijun; Ohye, Hidemi; Kubota, Sumihisa; Fukata, Shuji; Amino, Nobuyuki; Kuma, Kanji; Sasaki, Ichiro; Hiraiwa, Tomoko; Hanafusa, Toshiaki; Takamatsu, Junta; Miyauchi, Akira

doi:10.1210/jc.2006-1605

Cited by 65 publications

(51 citation statements)

References 21 publications

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“…In cases of hypothyroidism, how the serum Lp(a) levels are influenced by thyroid hormone remains unknown and contradictory results on the effect of thyroid hormone replacement on serum Lp(a) levels have been reported [6][7][8][9][10][11][12][13]. Although an altered lipid profile is frequently observed in patients with thyroid dysfunction, published data on the relationship between Lp(a) and thyroid status are controversial [14].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Lipoprotein(a) and Thyroid Hormones in Hypothyroid Patients

Kaliaperumal

William

Selvam

et al. 2014

JCDR

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Background and Objective: Changes in plasma lipid con cen trations are well known metabolic consequences of thyroid dysfunction. The alterations are most prominent in hypothyroidism which is typically associated with pronounced hypercholesterolaemia and frequently with moderate hyper triglyceridaemia. In cases of hypothyroidism, how the serum Lp(a) levels are influenced by thyroid hormone remains unknown and contradictory results on the effect of thyroid hormone on serum Lp(a) levels have been reported. There is substantial evidence to suggest that elevated serum Lp(a) levels contribute significantly to the development of CHD. The present study was designed to determine the lipoprotein(a) [Lp(a)], lipid profile and thyroid hormone levels in newly diagnosed hypothyroid patients and to find any correlation that existed between Lp(a) and other parameters.

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Section: Introductionmentioning

confidence: 99%

Relationship between Lipoprotein(a) and Thyroid Hormones in Hypothyroid Patients

Kaliaperumal

William

Selvam

et al. 2014

JCDR

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“…32 In another study, a significant reduction in the concentrations of total cholesterol, non-HDL and apo-B was found, but without significant changes in the serum concentrations of LDL, HDL cholesterol, TGL, apolipoprotein A-I, and Lp(a) after levo-thyroxine replacement. 33 The reduction in total cholesterol levels were inversely correlated with an increase in free T4 levels, but not correlated with changes in TSH levels.…”

Section: Discussionmentioning

confidence: 86%

Prevalence of subclinical hypothyroidism in children and adolescents of northern Andhra Pradesh population and its association with hyperlipidemia

2017

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Background: The thyroid dysfunction particularly, subclinical hypothyroidism (SCH) is quite a common clinical condition in paediatric population but there is limited data available regarding its prevalence in children and adolescents in our population. The present study was aimed to know the prevalence of thyroid dysfunction particularly SCH in children and adolescents of northern Andhra Pradesh population and its association with hyperlipidemia.Methods: A retrospective study of 600 subjects (Children=272, Adolescents=328) between 6-19 years of age were included and the following parameters were examined: age, sex, total triiodothyronine (tT3), total tetraiodothyronine (tT4), thyroid stimulating hormone (TSH), total cholesterol, triglycerides (TGL), LDL and HDL cholesterol. The subjects were divided into group I and group II on the basis of age (in years), subjects between 6- ≤12 years age were grouped as group I and 12-≤19 years were as group II.Results: Out of 272 children and 328 adolescents studied, the prevalence of thyroid dysfunction was found to be 9.9% and 10.4 % respectively. The prevalence of subclinical hypothyroidism in children was 7.7% where as 4.9% in adolescents. In both the groups, females were predominantly affected with thyroid dysfunction as compared to males. Significantly elevated serum levels of total cholesterol, TSH and TGL were observed in SCH subjects when compared to euthyroid subjects (p<0.05). Statistically significant lower levels of HDL cholesterol were found in SCH as compared to euthyroids (p<0.05). However, no difference was noticed in the levels of total T3, total T4 and LDL cholesterol between SCH and euthyroids.Conclusions: The prevalence of thyroid dysfunction was found to be 10.2% in study population. SCH was observed in 7.7 % and 4.9% respectively in children and adolescent groups. Subclinical hypothyroidism (SCH) was the most predominant thyroid dysfunction found in our studied population with a prevalence of 6.2% (both children and adolescents). Correction of thyroid dysfunction particularly SCH in early childhood is highly essential to prevent the impairment of psychomotor and cognitive development.

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“…Furthermore, there was a positive correlation between the reduction in TSH and apoB-48, suggesting that L-T4 replacement therapy improves lipid abnormalities as well as thyroid function. Ito et al also reported that serum TC, non-HDL-C, LDL-C, apoB and RLP-C were markedly decreased after 3 months' treatment 41) ; therefore, it can be speculated that L-T4 replacement therapy might be effective to improve the impaired metabolism of CMR, as well as VLDL or LDL.…”

Section: Discussionmentioning

confidence: 99%

Thyroid Function Influences Serum Apolipoprotein B-48 Levels in Patients with Thyroid Disease

Mugii

Hanada

Okubo

et al. 2012

JAT

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Aim: Apolipoprotein B-48 (apoB-48) is a major apolipoprotein of intestine-derived chylomicrons (CM) and CM remnants (CMR).Clinically overt hypothyroidism (OH) has been associated with premature and accelerated coronary atherosclerosis. To clarify the clinical significance of apoB-48 measurement in patients with thyroid disease, we investigated the correlations between the serum apoB-48 level and thyroid hormones. Methods: From outpatients of Osaka University Hospital, patients with OH, subjects with subclinical hypothyroidism (SH) and subjects with normal thyroid function were collected and analyzed by measuring serum TSH, FT4 and FT3 levels. Serum apoB-48 levels were measured by a chemiluminescence enzyme immunoassay and the correlations with thyroid hormone levels or lipid profiles were assessed. These levels were compared among subjects with OH, SH and healthy controls. Results: Serum apoB-48 level was correlated with TSH, total cholesterol (TC) and triglycerides (TG), but negatively with FT4 and FT3 level. LDL-C and HDL-C levels were not correlated with serum apoB-48 levels. Serum apoB-48 in patients with OH (7.4±5.9 μg/mL) was significantly higher than in those with hyperthyroidism (5.1±3.5 μg/mL; p＜0.01) and normal subjects (4.7±3.7 μg/mL; p＜0.01), but decreased after levo-thyroxine replacement. ApoB-48, TG and TSH were significantly higher in SH subjects than normal subjects, suggesting that serum apoB-48 level depends on the thyroid function status, similar to TC, LDL-C and TG. Conclusion: Increased serum apoB-48 concentrations and CMR may contribute to the increased risk of atherosclerosis and premature coronary artery disease in the hypothyroid state.

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Effect of Levo-Thyroxine Replacement on Non-High-Density Lipoprotein Cholesterol in Hypothyroid Patients

Cited by 65 publications

References 21 publications

Relationship between Lipoprotein(a) and Thyroid Hormones in Hypothyroid Patients

Relationship between Lipoprotein(a) and Thyroid Hormones in Hypothyroid Patients

Prevalence of subclinical hypothyroidism in children and adolescents of northern Andhra Pradesh population and its association with hyperlipidemia

Thyroid Function Influences Serum Apolipoprotein B-48 Levels in Patients with Thyroid Disease

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