Effect of Laser Photostimulation on the Healing of Third-Degree Burn wounds in Rats

Fekrazad, Reza; Nikkerdar, Alireza; Joharchi, Khojasteh; Kalhori, Katayoun Am; Abbas, Fatemeh Mashhadi

doi:10.5812/jamm.22315

Cited by 3 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Burn injuries affect more than 11 million people annually worldwide [4] and can be caused by heat, chemicals, electricity, and radiation, among other things. They are classified as first-degree burn (superficial, reaches the epidermis), second-degree burn (partial thickness, reaches the epidermis and a part of the dermis), and third-degree burn (total thickness, reaches the epidermis, dermis, hypodermis, and muscles) [5,6]. The depth of the burn is related to the time of exposure to the aggressive agent, temperature, and pressure under the tissue, and these factors usually determine the prognosis after injury [7].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Potential of Brassica oleracea Accelerates Third-Degree Burn Healing in Rats

Miranda,

Sarandy,

Altoé

et al. 2024

Cosmetics

View full text Add to dashboard Cite

Burns account for more than 265,000 deaths per year in the world, mainly associated with infections. Therefore, the shorter the healing time, the better the prognosis. Based on this, the objective of the present study was to investigate the effect of an ointment based on Brassica oleracea var. capitata extract in the third-degree healing process. Twenty-five male Wistar rats (335 ± 16 g, three months of life) were individualized in cages with food and water ad libitum. After anesthesia, two circular third-degree burn wounds (12 mm in diameter) were made on the animals, which were randomly separated into five treatments (n = 5/group), i.e., SAL: saline solution 0.9%; OV: ointment vehicle; SS: silver sulfadiazine 1%; PB1: 10% B. oleracea extract; and PB2: 20% B. oleracea extract. The animals were treated with the ointment daily for eight days. Every four days, the area and the wound contraction index were evaluated. Tissue samples were taken for histopathological analysis (cellularity, blood vessels, and extracellular matrix components) and analysis of oxidative/nitrosative status (antioxidant enzymes, lipid, and protein oxidation markers, as well as nitric oxide (NO) and hydrogen peroxide (H2O2)). The ointment based on B. oleracea var. capitata at 10 and 20% concentrations increased the number of cells, blood vessels, and fibrous components of the extracellular matrix and the activity of antioxidant enzymes, promoting a fast and efficient cutaneous repair in third-degree burn wounds.

show abstract

Section: Introductionmentioning

confidence: 99%