Archives of Dermatology
 1988
DOI: 10.1001/archderm.124.4.540
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Effect of isotretinoin on serum levels of precursor and peripherally derived androgens in patients with acne

Donald P. Lookingbill1
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Cited by 9 publications

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“…Isotretinoin is a drug that is currently used to treat acne because of its antiandrogenic effect 118 . Indeed, isotretinoin diminishes the serum levels of dihydrotestosterone, 119,120 which is an androgen that promotes the transcription of TMPRSS2 109,121 . The effect of androgens on regulating the expression of TMPRSS2 was previously reported on lungs 122 .…”
Section: Active Clinical Trialsmentioning
confidence: 95%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Isotretinoin is a drug that is currently used to treat acne because of its antiandrogenic effect 118 . Indeed, isotretinoin diminishes the serum levels of dihydrotestosterone, 119,120 which is an androgen that promotes the transcription of TMPRSS2 109,121 . The effect of androgens on regulating the expression of TMPRSS2 was previously reported on lungs 122 .…”
Section: Active Clinical Trialsmentioning
confidence: 95%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…In young men, a statistically signi¢cant correlation was found between serum 3a -Adiol glucuronide and chest hairiness, acne as well as a combined chest hairiness and acne score (Lookingbill et al, 1988b). Noteworthy was the decreased serum levels of 3a -Adiol glucuronide in 24 acne subjects (15 men and nine women) treated with 1mg isotretinoin per kg bodyweight per day for 20 wk (Lookingbill et al, 1988a).…”
Section: Androgen-dependent Dermatosesmentioning
confidence: 95%
“…Keratinocytes were found to inactivate tissue active androgens in a more pronounced manner than sebocytes do by engagement of 3a -HSD (Fritsch et al, 2001). Clinically, it is still controversial if serum levels of 3a-Adiol conjugates (3a-Adiol glucuronide or 3a-Adiol sulfate) serve as reliable indicator for cutaneous 5a-DHT formation (see later, Lookingbill et al, 1988a;Horton, 1992;Vogt et al, 1992), or are just a marker of adrenal steroid production and metabolism (Rittmaster, 1995). Interestingly, rat liver 3a-HSD was found to be a target for nonsteroidal anti-in£ammatory drugs (Pawlowski et al, 1991).…”
Section: Cytochrome P450 19 (Aromatase)mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…First results of decreased 5α-reductase activity after isotretinoin treatment have been attributed to the reduced total volume of sebaceous glands [40]. However, Rademaker et al [41] reported a decrease in liver 5α-reductase in 13- cis -retinoic-acid treated women.…”
Section: Nonsteroidal Antiandrogensmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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