2018
DOI: 10.1097/scs.0000000000004089 View full text |Buy / Rent full text
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Abstract: Antiseptic solutions are commonly utilized to treat local infection in the oral and maxillofacial region. However, surrounding vital bone is also exposed to antiseptic agents during irrigation and may have a potential negative impact on bone survival. The aim of the present study was therefore to investigate the effect of rinsing time with various antiseptic solutions on bone cell viability, as well as their subsequent release of growth factors important for bone regeneration. The bone samples collected from p… Show more

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“…Previously, our research team investigated four commonly utilized antiseptic solutions, including (1) povidone-iodine (PI, 0.5%), (2) CHX (0.2%), (3) hydrogen peroxide (H 2 O 2 , 1%), and (4) sodium hypochlorite (HYP, 0.25%) on bone chip cell viability and growth factor release of VEGF, TGFB1, BMP2, RANKL, and IL1β [ 20 ]. It was actually reported following antiseptic rinsing that the CHX-rinsed bone chips demonstrated the highest cellular viability between all the antiseptic solutions however nearly 50% of the cells underwent dead [ 20 , 21 ].…”
Section: Discussionmentioning
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“…Previously, our research team investigated four commonly utilized antiseptic solutions, including (1) povidone-iodine (PI, 0.5%), (2) CHX (0.2%), (3) hydrogen peroxide (H 2 O 2 , 1%), and (4) sodium hypochlorite (HYP, 0.25%) on bone chip cell viability and growth factor release of VEGF, TGFB1, BMP2, RANKL, and IL1β [ 20 ]. It was actually reported following antiseptic rinsing that the CHX-rinsed bone chips demonstrated the highest cellular viability between all the antiseptic solutions however nearly 50% of the cells underwent dead [ 20 , 21 ].…”
Section: Discussionmentioning
“…These effects seem to be concentration dependent according to the data of Kozol et al, who investigated neutrophil, fibroblast and endothelial cell viability after treatment with 0.025-0.0025% NaOCl for an exposure time of 30 min and reported cytoplasmic vacuolation, swollen mitochondria and dilated endoplasmic reticulum in fibroblasts and endothelial cells, but no cell deaths [14]. Sawada et al showed a decrease in viable cells after 10-min rinsing with 0.25% NaOCl [11]. Vouzara et al reported a cytotoxic effect of NaOCl on MRC5 cells (human lung fibroblasts) [12] and Hidalgo et al on dermal fibroblasts, depending on concentration and exposure time [10].…”
Section: Discussionmentioning
“…Comparing CHG to NaOCl, Sawada et al reported a higher cytotoxic effect of NaOCl than CHG after investigating antiseptic solution in dentistry bone samples. They showed higher cell viability after rinsing with 0.2% CHG than 0.25% NaOCl for different exposure times [4,11]. On the other hand, Vouzara et al reported a higher cytotoxic effect of CHG than NaOCl on MRC5 cell samples at different concentrations of the solutions after 6 and 24 h [12].…”
Section: Discussionmentioning
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