Effect of irradiation on vestibular evoked myogenic potentials in nasopharyngeal carcinoma survivors

Wu, Chen‐Chi; Young, Yi‐Ho; Ko, Jenq‐Yuh

doi:10.1002/hed.10215

Cited by 11 publications

(11 citation statements)

References 21 publications

(23 reference statements)

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“…64 In survivors of irradiated nasopharyngeal carcinoma, p13 and n23 latencies were delayed in 50% of the ears in subjects irradiated once and 100% of the ears in those irradiated twice. 70 These abnormalities were attributed to brainstem pathology.…”

Section: Vemps Evoked By Galvanic Stimulationmentioning

confidence: 98%

Characteristics and clinical applications of vestibular-evoked myogenic potentials

Welgampola¹,

Colebatch²

2005

Neurology

372

290

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A recent technique of assessing vestibular function, the vestibular-evoked myogenic potential (VEMP), is an otolith-mediated, short-latency reflex recorded from averaged sternocleidomastoid electromyography in response to intense auditory clicks delivered via headphones. Since their first description 10 years ago, VEMPs are now being used by investigators worldwide, and characteristic changes observed with aging and in a variety of peripheral and central vestibulopathies have been described. Additional methods of evoking VEMPs, which use air- and bone-conducted short-tone bursts, forehead taps, and short-duration transmastoid direct current (DC) stimulation, have been described, and these complement the original technique. Click-evoked VEMPs are attenuated or absent in a proportion of patients with vestibular neuritis, herpes zoster oticus, late Meniere disease, and vestibular schwannomas; their amplitudes are increased and thresholds are pathologically lowered in superior semicircular canal dehiscence presenting with the Tullio phenomenon. VEMPs evoked by clicks and DC are useful when monitoring the efficacy of intratympanic gentamicin therapy used for chemical vestibular ablation. Prolonged p13 and n23 peak latencies and decreased amplitudes have been observed in association with central vestibulopathy. VEMPs evoked by clicks are a robust, reproducible screening test of otolith function. DC stimulation enables differentiation of labyrinthine from retrolabyrinthine lesions; bone-conducted stimuli permit VEMP recording despite conductive hearing loss and deliver a relatively larger vestibular stimulus for a given level of auditory perception.

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Section: Vemps Evoked By Galvanic Stimulationmentioning

confidence: 98%

Characteristics and clinical applications of vestibular-evoked myogenic potentials

Welgampola¹,

Colebatch²

2005

Neurology

372

290

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“…In 12 patients undergoing VEMP test, excluding one patient aged > 60 years, percentages of abnormal VEMPs remained the same (Table ). Although cVEMP test was not performed in NPC patients prior to irradiation, our previous study reported that normal cVEMPs were identified in fresh NPC patients, which further supports that abnormal cVEMPs in NPC survivors are unrelated to NPC itself but irradiation.…”

Section: Discussionmentioning

confidence: 56%

Evolution of postirradiated sudden deafness in nasopharyngeal carcinoma survivors during the past two decades

2016

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“…Absence of VEMPs has been, in addition, reported in 19Á25% of sides tested [10]. A prolongation of VEMPs was also shown in large vestibular schwannomas compressing the brainstem [9] and in survivors of nasopharyngeal carcinoma after irradiation [11].…”

Section: Discussionmentioning

confidence: 95%

Vestibular evoked myogenic potentials (VEMPs) in whiplash injury: a prospective study

Solarino¹,

Coppola²,

Vella³

et al. 2009

Acta Oto-Laryngologica

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All subjects presented normal hearing, normal impedence audiometry findings, and normal vestibular function. VEMPs were present both in patients affected by whiplash injury and in the control group at time 0. At 90 days VEMPs were absent in two cases (14.3%). Statistical analysis showed that at time 0 and at time 90 days p1 latency was significantly higher in whiplash patients compared with healthy subjects on both sides (p < 0.002). The amplitude of p1-n1 was significantly lower in whiplash patients at time 0 (p = 0.003 on the right and p = 0.018 on the left), but not at 90 days.

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Effect of irradiation on vestibular evoked myogenic potentials in nasopharyngeal carcinoma survivors

Abstract: Delayed VEMPs in NPC survivors are possibly due to radiation-induced otitis media, a brainstem lesion, or neck fibrosis. Hence, VEMP testing may expand the test battery for clinicians to explore balance problems in NPC survivors after irradiation.

Cited by 11 publications

References 21 publications

Characteristics and clinical applications of vestibular-evoked myogenic potentials

Characteristics and clinical applications of vestibular-evoked myogenic potentials

Evolution of postirradiated sudden deafness in nasopharyngeal carcinoma survivors during the past two decades

Vestibular evoked myogenic potentials (VEMPs) in whiplash injury: a prospective study

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