EFFECT OF INTRAVENOUS INFUSION OF d-MANNOHEPTULOSE ON BLOOD GLUCOSE AND INSULIN LEVELS IN MAN

Lev-Ran, Arye; Laor, J; Винс, М. В.; Simon, Ernst

doi:10.1677/joe.0.0470137

Cited by 10 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among pharmacologic inhibitors of insulin secretion, propranolol, mannoheptulose, and 2-deoxy-glucose are not able to inhibit as many diverse stimuli for insulin release as somatostatin (25,(27)(28)(29). Diazoxide and diphenylhydantoin are widely effective inhibitors of insulin secretion (25,30), but their in vivo effectiveness does not match that of somatostatin (31,32).…”

Section: Discussionmentioning

confidence: 99%

Somatostatin blockade of acute and chronic stimuli of the endocrine pancreas and the consequences of this blockade on glucose homeostasis.

Chideckel¹,

Palmer²,

Koerker³

et al. 1975

J. Clin. Invest.

104

View full text Add to dashboard Cite

A B S T R A C T The nature and extent of somatostatininduced inhibition of pancreatic endocrine secretion were studied by administration of a number of stimuli of either glucagon or insulin to overnight fasted baboons with and without an infusion of linear somatostatin. The stimuli for acute-phase insulin release were intravenous pulses of glucose, tolbutamide, isoproterenol, and secretin. When given 15 min after the start of a somatostatin infusion, these agents were essentially unable to stimulate insulin secretion. Chronic insulin secretion was stimulated by infusions of either glucose or glucagon. Within 10 min of the start of a superimposed infusion of somatostatin, insulin levels fell to less than 40% of prestimulus control and remained suppressed for the duration of the somatostatin infusion. Stimulation of glucagon secretion by insulin-induced hypoglycemia was also blocked by somatostatin.Plasma glucose decreased during somatostatin infusions except when superimposed upon an infusion of glucagon. Somatostatin had no effect on glucose production in a rat liver slice preparation.We conclude: (a) Somatostatin is a potent and so far universally effective inhibitor of both acute and chronic phases of stimulated insulin and glucagon secretion (b) The inhibitory effect is quickly reversible and the pattern of recovery of secretion is appropriate to prevailing signals; (c) Present evidence suggests that the effect of somatostatin on blood glucose is mediated through its effect on blood glucagon; (d) In the overnight-fasted baboon both in the basal state and 45 min into a 4-mg/kg min glucose infusion, a somatostatininduced fall in serum insulin levels appears to be unable to prevent a decrease in hepatic glucose production.

show abstract

Section: Discussionmentioning

confidence: 99%

Somatostatin blockade of acute and chronic stimuli of the endocrine pancreas and the consequences of this blockade on glucose homeostasis.

Chideckel¹,

Palmer²,

Koerker³

et al. 1975

J. Clin. Invest.

104

View full text Add to dashboard Cite

show abstract

“…Interest in the potential therapeutic activity of MH was stimulated by early studies in humans demonstrating its potential for treating hypoglycemia. When MH was delivered intravenously, a major increase in blood glucose was observed accompanied by a marked decrease in blood insulin. , The mechanism for the enhanced blood glucose levels was purported to be MH-induced inhibition of pancreatic β cells to produce insulin. Further clinical application of synthetic MH was impractical given the high cost of its production.…”

Section: Introductionmentioning

confidence: 99%

Characterization and Mechanisms of Action of Avocado Extract Enriched in Mannoheptulose as a Candidate Calorie Restriction Mimetic

Ingram

Pistell

Wang

et al. 2021

J. Agric. Food Chem.

View full text Add to dashboard Cite

Increased consumer interest in the avocado (Persea americana or Persea gratissima) has been attributed to established health benefits of this fruit associated with a wide range of ingredients. In search of effective calorie restriction mimetics (CRM), we present herein a consideration of possible health benefits of the rare sugar, mannoheptulose (MH), which acts as an intracellular glycolytic inhibitor and presents the highest concentration of this inhibitor in unripe avocados. A method for producing an extract of unripe avocado (AvX) to enrich concentrations of MH is described. Experiments using myocyte cultures demonstrated a pattern of CRM-like responses when treated with AvX. In vivo experiments confirmed that orally consumed AvX is bioavailable in both mice and dogs, as observed in urine and blood samples. Additional experiments in both these species demonstrated CRM-like improvements in glucose and insulin responses. In sum, the MH-enriched AvX exhibits promise as a CRM.

show abstract

“…The potential therapeutic benefits of MH were identified in early human studies focused on its potential for improving hypoglycemia [ 8 , 9 ]. Major increases in blood glucose levels could be produced via iv delivery of MH with concomitant decreases in serum insulin levels.…”

Section: Introductionmentioning

confidence: 99%

An Avocado Extract Enriched in Mannoheptulose Prevents the Negative Effects of a High-Fat Diet in Mice

et al. 2021

View full text Add to dashboard Cite

Beginning at 16 weeks of age and continuing for 44 weeks, male C57BL/6J were fed either a control (CON) diet; a high-fat (HF) diet (60% unsaturated); or the HF diet containing an extract of unripe avocados (AvX) enriched in the 7-carbon sugar mannoheptulose (MH), designed to act as a glycolytic inhibitor (HF + MH). Compared to the CON diet, mice on the HF diet exhibited higher body weights; body fat; blood lipids; and leptin with reduced adiponectin levels, insulin sensitivity, VO2max, and falls from a rotarod. Mice on the HF + MH diet were completely protected against these changes in the absence of significant diet effects on food intake. Compared to the CON diet, oxidative stress was also increased by the HF diet indicated by higher levels of total reactive oxygen species, superoxide, and peroxynitrite measured in liver samples by electron paramagnetic resonance spectroscopy, whereas the HF + MH diet attenuated these changes. Compared to the CON, the HF diet increased signaling in the mechanistic target of the rapamycin (mTOR) pathway, and the addition of the MH-enriched AvX to this diet attenuated these changes. Beyond generating further interest in the health benefits of avocados, these results draw further new attention to the effects of this rare sugar, MH, as a botanical intervention for preventing obesity.

show abstract

EFFECT OF INTRAVENOUS INFUSION OF d-MANNOHEPTULOSE ON BLOOD GLUCOSE AND INSULIN LEVELS IN MAN

Cited by 10 publications

References 0 publications

Somatostatin blockade of acute and chronic stimuli of the endocrine pancreas and the consequences of this blockade on glucose homeostasis.

Somatostatin blockade of acute and chronic stimuli of the endocrine pancreas and the consequences of this blockade on glucose homeostasis.

Characterization and Mechanisms of Action of Avocado Extract Enriched in Mannoheptulose as a Candidate Calorie Restriction Mimetic

An Avocado Extract Enriched in Mannoheptulose Prevents the Negative Effects of a High-Fat Diet in Mice

Contact Info

Product

Resources

About