Effect of Intraocular Miotics on Corneal Endothelium

Investigation of the effects of intracameral carbachol on oxidative stress and apoptosis in rat corneas

“…In these studies, intracameral carbachol was found to be an anatomically and physiologically safe drug for use on the corneal endothelium. [6][7][8][9] In our study, carbachol did not increase oxidative stress and apoptosis.…”

“…No cellular changes were observed in the electron microscope. Vaughn et al [7] found that carbachol had no effect on corneal thickness. Olson et al [16] showed that carbachol and commonly used intraocular medications had no significant effect on specular microscopy and the corneal endothelial in cats.…”

Investigation of the effects of intracameral carbachol on oxidative stress and apoptosis in rat corneas

“…In these studies, intracameral carbachol was found to be an anatomically and physiologically safe drug for use on the corneal endothelium. [6][7][8][9] In our study, carbachol did not increase oxidative stress and apoptosis.…”

“…No cellular changes were observed in the electron microscope. Vaughn et al [7] found that carbachol had no effect on corneal thickness. Olson et al [16] showed that carbachol and commonly used intraocular medications had no significant effect on specular microscopy and the corneal endothelial in cats.…”

Effect of Intraocular Acetylcholine and Carbachol on the Corneal Endothelium

“…However these authors recommended more caution in carbachol use in corneas with an altered endothelial pattern [6]. Successively, after carbachol solution reformulation with pH variation from 5.2 to 6.95 this same study was carried out by Birnbaum et al [7], who observed a high improvement in endothelial resistance with carbachol.…”

“…The toxic endothelial effect of intraocular miotics was studied in vitro by Vaughn et al [6], who observed a transient corneal edema without permanent endothelial cell damage after carbachol perfusion, while acetylcholine chloride did not alter either endothelial cell morphology or function. However these authors recommended more caution in carbachol use in corneas with an altered endothelial pattern [6].…”

“…In spite of a widespread use of these agents, the current literature contains only a small number of reports about their endothelial toxicity and results are conflicting [6][7][8][9][10].…”

Investigation of the effects of intracameral carbachol on oxidative stress and apoptosis in rat corneas

“…In these studies, intracameral carbachol was found to be an anatomically and physiologically safe drug for use on the corneal endothelium. [6][7][8][9] In our study, carbachol did not increase oxidative stress and apoptosis.…”

“…No cellular changes were observed in the electron microscope. Vaughn et al [7] found that carbachol had no effect on corneal thickness. Olson et al [16] showed that carbachol and commonly used intraocular medications had no significant effect on specular microscopy and the corneal endothelial in cats.…”

Effect of Intraocular Acetylcholine and Carbachol on the Corneal Endothelium

“…However these authors recommended more caution in carbachol use in corneas with an altered endothelial pattern [6]. Successively, after carbachol solution reformulation with pH variation from 5.2 to 6.95 this same study was carried out by Birnbaum et al [7], who observed a high improvement in endothelial resistance with carbachol.…”

“…The toxic endothelial effect of intraocular miotics was studied in vitro by Vaughn et al [6], who observed a transient corneal edema without permanent endothelial cell damage after carbachol perfusion, while acetylcholine chloride did not alter either endothelial cell morphology or function. However these authors recommended more caution in carbachol use in corneas with an altered endothelial pattern [6].…”

“…In spite of a widespread use of these agents, the current literature contains only a small number of reports about their endothelial toxicity and results are conflicting [6][7][8][9][10].…”

Investigation of the effects of intracameral carbachol on oxidative stress and apoptosis in rat corneas

“…In these studies, intracameral carbachol was found to be an anatomically and physiologically safe drug for use on the corneal endothelium. [6][7][8][9] In our study, carbachol did not increase oxidative stress and apoptosis.…”

“…No cellular changes were observed in the electron microscope. Vaughn et al [7] found that carbachol had no effect on corneal thickness. Olson et al [16] showed that carbachol and commonly used intraocular medications had no significant effect on specular microscopy and the corneal endothelial in cats.…”

Effect of Intraocular Acetylcholine and Carbachol on the Corneal Endothelium

“…However these authors recommended more caution in carbachol use in corneas with an altered endothelial pattern [6]. Successively, after carbachol solution reformulation with pH variation from 5.2 to 6.95 this same study was carried out by Birnbaum et al [7], who observed a high improvement in endothelial resistance with carbachol.…”

“…The toxic endothelial effect of intraocular miotics was studied in vitro by Vaughn et al [6], who observed a transient corneal edema without permanent endothelial cell damage after carbachol perfusion, while acetylcholine chloride did not alter either endothelial cell morphology or function. However these authors recommended more caution in carbachol use in corneas with an altered endothelial pattern [6].…”

“…In spite of a widespread use of these agents, the current literature contains only a small number of reports about their endothelial toxicity and results are conflicting [6][7][8][9][10].…”