Effect of intranasally administered insulin on cerebral blood flow and perfusion; a randomized experiment in young and older adults

Akintola, Abimbola A.; Am, van Opstal; Westendorp, Rudi G. J.; Postmus, Iris; J, van der Grond; D, van Heemst

doi:10.18632/aging.101192

Cited by 24 publications

(32 citation statements)

References 38 publications

(37 reference statements)

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“…Also, insulin has been shown to be a vasoactive modulator that regulates peripheral and cerebral blood flow possibly via a direct vasodilatory effect [12]. Taken together, our finding of increased perfusion in some brain areas would support the hypothesis that intranasal insulin application might restore energy demand and neuronal activity in these regions [4,10].…”

Section: The Perfusion Of Intranasal Insulin In Contextsupporting

confidence: 73%

“…Intranasal administration of insulin also significantly increased perfusion through the occipital and parietal gray matter in older adults [10]. The occipital lobe is the visual processing center of the mammalian brain containing most of the anatomical region of the primary visual cortex.…”

Section: The Thalamus and Occipital Structures In Language Attentionmentioning

confidence: 96%

“…Deep inside the medial temporal lobe is the region of the brain which includes the hippocampus, the amygdala, the cingulate gyrus, the thalamus, the hypothalamus, the epithalamus, the mammillary body, and other organs, many of which are of particular relevance to the processing of memory. Studies of single-dose intranasal insulin demonstrate that intranasal does reach the hypothalamus but these results did not reach statistically significant levels ( [10]:793). Other single-dose studies of intranasal insulin to diabetics showed acutely increased resting-state functional connectivity between the hippocampal regions and multiple regions within the DMN, i.e., the medial frontal cortex; the medial, lateral, and inferior parietal cortex (IPC); and anterior (ACC) and posterior cingulate cortex (PCC).…”

Section: Ct Scans and Progression From MCI To Admentioning

confidence: 98%

“…1 Recent studies of the perfusion of intranasal insulin into the regional areas of the brain cortex demonstrate two main regional cortical areas of penetration. Akintola et al [10] found that, in older adults, intranasal administration of insulin significantly increased perfusion through the occipital gray matter by 6.5% (P = 0.001) when compared to the administration of placebo as well as perfusion into the thalamus (P = 0.003). Perfusion through the parietal gray matter was also increased by 4.3% after administration (P = 0.034) in older adults.…”

Section: The Perfusion Of Intranasal Insulin In Contextmentioning

confidence: 99%

“…Conversely, patients on extended intranasal insulin should demonstrate slower rates of atrophy as the insulin restores energy demand and neuronal activity in occipital and parietal gray matter regions and the thalamus [10]. CT scans over the AD disease course of a patient receiving extended intranasal insulin can be hypothesized to illustrate patterns closer to "normal aging" of MCI even 5-6 years after AD diagnosis (see also Additional materials).…”

Section: Ct Scans and Progression From MCI To Admentioning

confidence: 99%

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Intranasal Insulin as Promising Therapy for Preserving Pragmatic Competence in MCI and AD

Schatz¹

2020

Neurostimulation and Neuromodulation in Contemporary Therapeutic Practice

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Our chapter contends that extended intranasal insulin administration can preserve pragmatic functioning even when there are temporal lobe and frontal lobe brain volume losses consistent with AD disease progression. CT scans of a patient receiving extended intranasal insulin 6 years after AD diagnosis are compared with his CT scans at the original MCI diagnosis. The results demonstrate that areas of the brain associated with pragmatic functioning were not as affected as expected in late-stage AD patients. This, along with linguistic evidence of preserved pragmatic competence, indicates the likely effectiveness of intranasal insulin treatment in enhancing neuronal activity in certain areas of the brain associated with pragmatic competence.

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Section: The Perfusion Of Intranasal Insulin In Contextsupporting

confidence: 73%

Section: The Thalamus and Occipital Structures In Language Attentionmentioning

confidence: 96%

Section: Ct Scans and Progression From MCI To Admentioning

confidence: 98%

Section: The Perfusion Of Intranasal Insulin In Contextmentioning

confidence: 99%

Section: Ct Scans and Progression From MCI To Admentioning

confidence: 99%

See 3 more Smart Citations