Effect of intraarterial papaverine or nimodipine on vessel diameter in patients with cerebral vasospasm after subarachnoid hemorrhage

Kerz, Thomas; Boor, Stephan; Beyer, Christian; Welschehold, Stefan; Schuessler, Anke; Oertel, Joachim

doi:10.3109/02688697.2011.650737

Cited by 37 publications

(25 citation statements)

References 28 publications

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“…Angiographic resolution of diameter reduction and angiographically assessed capillary blood flow together differed not significantly between papaverine and nimodipine treated groups. Papaverine infusion dilated all angiographic demonstrable vessels while nimodipine infusion was ineffective in 16% of the patients [90]. Capillary flow on pre-and post-infusion angiographies was not different between these two groups.…”

Section: Intraarterial Agents (Papaverine Nimodipine)mentioning

confidence: 77%

Cerebral vasospasm: a review of current developments in drug therapy and research

Archavlis¹,

Nievas²

2013

J Pharm Technol Drug Res

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In this manuscript a comprehensive coverage of recent developments in the drug therapy of vasospasm while providing the background information that neuroscientists need to understand its rationale. The range of new agents available for treatment of cerebral vasospasm is expanding rapidly along with rapid advances in pharmacology and physiology that are uncovering the mechanisms of this disease. Although there are many publications for treatment of cerebral vasospasm, most are focusing on different aspects of vasospasm treatment and many have limited value due to insufficient quality. Moreover, the complexity of this, in many cases deleterious condition, is enormous and the information needed to understand drug effects is accordingly often not readily available in a single source. A number of pharmacological and medical therapies are currently in use or being investigated in an attempt to reverse cerebral vasospasm, but only a few have proven to be useful. Curent research efforts promise the eventual production of new medical therapies. At last, recommendations for the use of different treatment stages based on currently available clinical data are provided.

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Section: Intraarterial Agents (Papaverine Nimodipine)mentioning

confidence: 77%

Cerebral vasospasm: a review of current developments in drug therapy and research

Archavlis¹,

Nievas²

2013

J Pharm Technol Drug Res

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“…Çoklu tedavileri gerektiren geçici etkisi ile beraber, papaverin kullanı-mının diğer bazı yan etkileri de mevcuttur. En ciddi ve hasar verebilen etkisi intrakraniyal basınçtaki artış (14,15,(22)(23)(24) , VS'ın kötüleşmesi, nörolojik bozulma ile gri madde hasarı (20,21,25) , beyin kök depresyonu (posterior sirkülasyonda kullanılması durumunda dikkat edilmelidir), nöbetler, kristal emboli oluşumuna ikincil olarak meydana gelen monoküler körlük ve geçici fokal nörolojik hasarlar olarak sıralanabilir (1,26) .…”

Section: Discussionunclassified

The results of Selective Intraarterial Papaverine Treatment Effect on Subarachnoidal Hemorrhage related Vasospasm

Çöven¹,

Kircelli²,

Peker³

et al. 2018

Okmeydani Medical Journal

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“…Papaverine is a short-acting vasodilator drug used most commonly in the treatment of arterial spasm and simulates the post-prandial state. 9,10 The 'normalization' of the pressure variables after intervention is unknown, but we would advocate a P d /P a ratio >0.90 and P a -P d (p) value of <20 mmHg, as evidenced in this case. This technique provided the necessary information to evaluate the hemodynamic significance of flow in the SMA after vasodilation before and after intervention.…”

Section: Discussionmentioning

confidence: 99%

Assessment of recurrent mesenteric ischemia after stenting with a pressure wire

Margiotta

Gray

2014

Vasc Med

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Chronic mesenteric artery ischemia can be difficult to evaluate after stent placement. This case describes the use of a pressure wire to demonstrate the hemodynamic significance of in-stent restenosis. Papaverine was used to vasodilate the mesenteric bed, mimicking the post-prandial state. The study (arteriography with pressure wire) and retreatment (covered balloon-expandable stent) was driven by recurrent symptoms avoiding unnecessary ancillary testing.

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Effect of intraarterial papaverine or nimodipine on vessel diameter in patients with cerebral vasospasm after subarachnoid hemorrhage

Abstract: P and N seem to differ in the effect on cerebral diameter reduction in patients with vasospasm after SAH. The clinical implications remain to be established. A multimodal approach, perhaps combining different agents for intraarterial infusion in such patients, needs to be evaluated.

Cited by 37 publications

References 28 publications

Cerebral vasospasm: a review of current developments in drug therapy and research

Cerebral vasospasm: a review of current developments in drug therapy and research

The results of Selective Intraarterial Papaverine Treatment Effect on Subarachnoidal Hemorrhage related Vasospasm

Assessment of recurrent mesenteric ischemia after stenting with a pressure wire

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