Effect of intermittent vitamin D3 on vascular function and symptoms in chronic fatigue syndrome – A randomised controlled trial

Effect of vitamin D3 on self-perceived fatigue

“…Last but not least, future prospective randomized studies should also address the question if the parameters of cardiovascular health could be improved by vitamin D treatment. Study by Witham et al [7] previously showed no improvement of CFS following a high-dose intermittent oral vitamin D therapy. There are possible explanations why our study results are different.…”

“…There are possible explanations why our study results are different. First, Witham et al [7] used the Fukuda et al [25] and Carruthers et al [26] CFS criteria for the study inclusion. In contrast, our population had no underlying illnesses and was younger.…”

“…[4] One randomized controlled trial tested the effect of high-dose vitamin D3 on symptoms in chronic fatigue syndrome (CFS), where no improvement of fatigue was found. [7] In another randomized controlled trial, muscle pains improved in a population of primary care patients with vitamin D deficiency. [8] Several uncontrolled studies suggested that fatigue may improve after correction of low vitamin D levels in individuals with stable chronic diseases, [9] breast cancer, [10] and myasthenia gravis.…”

Association of Serum 25-hydroxy-vitamin D Concentration and Arterial Stiffness among Korean Adults in Single Center

“…[1532] In the Framingham offspring study as well, vitamin D deficiency was found to be associated with an increased incidence of cardiovascular diseases. [41] Several studies have observed a successful decrease in baPWV prior to supplementation with vitamin D.[2627282930] However, a European cross-sectional study [40] as well as a cross-sectional analysis of the Korean Longitudinal Study on Health and Aging (KLoSHA) [39] showed no association between serum concentration of 25(OH)D and baPWV.…”

“…[25] However, there are many studies that have shown vitamin D to have a positive effect against arterial stiffness. [2627282930] We hypothesized that a higher concentration of serum 25(OH)D leads to reduced arterial stiffness. Therefore, we evaluated the relationship between 25(OH)D concentration and brachial-ankle PWV (baPWV) in Korean adults.…”