Effect of Inhaled Procaterol Hydrochloride in Children with Bronchial Asthma, with Particular Reference to Duration of Effect

Mitsuhashi, Masato; Kimura, T.; Tateno, K; Morikawa, Akihiro; Kuroume, Takayoshi

doi:10.3109/02770908509073144

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…There was more than a 60 min delay between the furosemide, cromolyn and procaterol inhalations to avoid drug interactions. Because the prolonged therapeutic effect of inhaled procaterol has been observed in children with bronchial asthma, 10 there was a 4 h delay in the furosemide inhalations in sequence of aerosolized procaterol. Oxygen saturation (SpO 2 ) was assessed with a Nellcor N180 Pulse Oximeter (Morita, Kyoto, Japan).…”

Section: Methodsmentioning

confidence: 99%

Inhaled furosemide is not effective in severe asthma in children

Matsumoto

Muraoka

Ogawa

et al. 2000

Allergology International

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The purpose of the present study was to determine whether or not inhaled furosemide has any therapeutic benefit in acute asthma in children. Aerosolized furosemide (20 mg) was administered four times per day together with conventional asthma therapy for 2 days in five children with severe asthma exacerbation. The oxygen saturation with a pulse oximeter (SpO2), and the peak expiratory flow (PEF) were measured before and 10 min after furosemide inhalation. Although a little improvement in SpO2 and PEF was observed after the furosemide inhalation, the results were inferior to those with an inhaled β2‐agonist (procaterol hydrochloride). Long‐term furosemide therapy was performed in two cases; however, amelioration of the SpO2 levels (> 90%) and PEF (> 80% of personal best) was not observed within 8 days of medication with furosemide. It is concluded that inhaled furosemide is not of additional benefit in children with severe exacerbation of asthma.

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Section: Methodsmentioning

confidence: 99%

Inhaled furosemide is not effective in severe asthma in children

Matsumoto

Muraoka

Ogawa

et al. 2000

Allergology International

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Single dose of inhaled procaterol has a prolonged effect on exercise performance of patients with COPD

Sukisaki

Senjyu

Oishi

et al. 2008

Physiotherapy Theory and Practice

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The aim of this study was to examine the prolonged effect of procaterol, a short-acting bronchodilator, on lung function and exercise performance in patients with moderate to severe COPD. A randomized crossover trial was conducted. We recruited 19 patients with COPD aged 71.6+/-5.5 years. Patients were randomly assigned to receive either 20 mug inhaled procaterol followed by no-treatment or no-treatment followed by 20 mug inhaled procaterol separated by a washout period of 3+/-2 days. Lung function and exercise performance, using the incremental shuttle walking test (ISWT), were measured at baseline and 4 hours after receiving each treatment. Baseline forced expiratory volume in 1 second (FEV(1)) was 38.5%+/-17% predicted. There were no significant changes in FEV(1) following inhaled procaterol. However, walking distance increased by 294+/-113 meters at baseline to 331+/-119 meters after inhaled procaterol (p<0.001). These findings support the beneficial effects of inhaled procaterol on exercise performance in the absence of any change in FEV(1) when measured at 4 hours following inhalation in subjects with moderate to severe COPD. The inhaled procaterol may be useful for enhancing the effects of exercise training in patients with COPD.

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Bronchial Hyperresponsiveness Changes After 5 Months of Regular Procaterol Inhalation Therapy in Asthmatic Children

et al. 1993

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It is well known that procaterol has more potent antiallergic properties than previous beta-stimulants. Thirteen children with asthma who could be controlled for 2 months with a regular procaterol aerosol given 4 times/day (10 micrograms/dose) were studied. Histamine challenges were performed before and an average of 5 months after the consecutive treatment. No significant differences were seen in peak expiratory flow values. PC20 increased significantly from 132.9 +/- 127.7 micrograms/ml to 762.4 +/- 1205.7 micrograms/ml after 5 months. These results suggest that asthmatic children who can be controlled with regular use of the beta-stimulant procaterol are likely to have a decreased bronchial hyperresponsiveness.

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Effect of Inhaled Procaterol Hydrochloride in Children with Bronchial Asthma, with Particular Reference to Duration of Effect

Cited by 3 publications

References 5 publications

Inhaled furosemide is not effective in severe asthma in children

Inhaled furosemide is not effective in severe asthma in children

Single dose of inhaled procaterol has a prolonged effect on exercise performance of patients with COPD

Bronchial Hyperresponsiveness Changes After 5 Months of Regular Procaterol Inhalation Therapy in Asthmatic Children

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