Effect of Inflammatory Mediators on Nasal Mucosa

The Permeability of Capillaries in the Eustachian Tube Mucosa

“…This may suggest that the higher perme ation of HRP in the subepithelial capillaries of the tube of the pharyngeal two-thirds may be induced by the active transportation of the large pore system. Jackson and Burson [1] reported that the nasal mu cosa was approximately 10 times as permeable to the pertechnetate ion as middle ear mucosa, and that nasal mucosa was also permeable to protein with the physio logical technique employed. In the eustachian tube, the greater permeability of the subepithelial capillaries of the pharyngeal two-thirds with mixed glands than that of the tympanic one-third without mixed glands has a mor phological basis as follows.…”

Lateral nasal gland secretion in the anaesthetized dog.

“…In the cat trachea a variety of prostaglandins increase mucin secretion (Richardson, Balfre & Hall, 1978). Histamine increases nasal secretion in 370 man (Melon, 1968;Konno & Togawa, 1979;Mygind, 1979) and the rat (Burns & Williams, 1977), but has little effect in the rabbit (Pell et al 1984), and increases nasal vascular permeability in the dog (Jackson & Burson, 1977).…”

The Canine Nasal Mucosa

“…The transport of antigens across the nasal mucoepithelial barrier and the production and/or release of antibodies onto the epithelial surface are poorly understood processes. Permeability of the nasal mucosa, of great interest in the 1950's (STROMME, 1952;YOFFEY, 1958), has received recent attention in the dog (HUSSAIN, HIRAI and BAWARSHI, 1980;JACKSON and BURSON, 1977). Permeability studies such as have been conducted on tracheal epithelium (BOUCHER, 1980;RICHARDSON, BOUCHER and FERGUSON, 1976;WATSON and BRAIN, 1979) have not been done on nasal epithelium.…”