2006
DOI: 10.1097/01.ta.0000245980.12711.6a View full text |Buy / Rent full text
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Abstract: Therapeutic mild hypothermia, induced either slowly (approximately -0.1 degrees C/min) or rapidly (approximately -0.4 degrees C/min) prolongs survival during lethal UHS in rats.

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“…16 -18 Takasu et al 19 showed that passive (ambient room temperature, 23°C) cooling, along with the use of alcohol and fans, was associated with an increased survival time for rats in a lethal period of uncontrolled hemorrhage. Wu et al 20 found that a period of severely controlled hemorrhage in rats (50% blood volume removed Ͼ10 minutes), followed by spontaneous hypothermia and resuscitation with induced hypothermia to maintain body temperature at 35°C, resulted in an increased survival time and in lower fluid resuscitation requirements.…”
Section: Discussionmentioning
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“…16 -18 Takasu et al 19 showed that passive (ambient room temperature, 23°C) cooling, along with the use of alcohol and fans, was associated with an increased survival time for rats in a lethal period of uncontrolled hemorrhage. Wu et al 20 found that a period of severely controlled hemorrhage in rats (50% blood volume removed Ͼ10 minutes), followed by spontaneous hypothermia and resuscitation with induced hypothermia to maintain body temperature at 35°C, resulted in an increased survival time and in lower fluid resuscitation requirements.…”
Section: Discussionmentioning
“…For example, Takasu and Wu used alcohol and ice to implement hypothermic treatment on uncontrolled hemorrhagic shock in rats. 27,28 Wladis et al 29 used a hypothermia bed to observe the effect of hypothermia on acute metabolism and endocrine responses after hemorrhagic shock. Gotberg et al utilized intravenous infusions of cold saline to induce hypothermia to observe the beneficial effect on cardiogenic shock in pigs.…”
Section: Discussionmentioning
“…[4] Hypothermia due to environmental losses and after surgery is related with uncontrolled hemorrhage and mortality in trauma patients. [10][11][12][13][14][15]25] Several studies [26][27][28] have demonstrated increased survival under conditions of hypothermia with controlled hemorrhage; however, another study [29] reported a higher mortality with hypothermia. In the present study, controlled, moderate hypothermia (32±0.5 °C) was assessed in one group of rats.…”
Section: Discussionmentioning