Effect of Imidacloprid and Tetraconazole on Various Hematological and Biochemical Parameters in Male Albino Rats (Rattus Norvegious)

Abbassy, Moustafa A.; Marzouk, Mamdouh A

doi:10.4172/2332-0761.1000122

Cited by 4 publications

(6 citation statements)

References 39 publications

(32 reference statements)

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“…There are many reports indicating adverse effects of imidacloprid in mammals, such as teratogenic (10,11), mutagenic (12), neurotoxic (13)(14)(15), and immunotoxic effects (16,17). The toxicity of imidacloprid is dose-dependent, as reported by a study that evaluated effects of 30 days oral administration of 1/85 LD 50 and 1/120 LD 50 of imidacloprid on thyroid toxicity in female rats (18) and a study of haematological and biochemical parameters in male rats after oral administration of 0.125 LD 50 and 0.1 LD 50 of imidacloprid, which correspond to the levels found in and on treated cucumbers one hour and one day after the application of imidacloprid, respectively (19).…”

supporting

confidence: 59%

Imidacloprid as reproductive toxicant and endocrine disruptor: investigations in laboratory animals

Mikolić

Karačonji

2018

Archives of Industrial Hygiene and Toxicology

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Imidacloprid, a neonicotinoid insecticide, has been used worldwide due to its selective toxicity for insects. Its residues may enter the food chain, which is why it is important to investigate the potential adverse effects of imidacloprid exposure. This review summarises current knowledge of the reproductive toxicity and disruptive endocrine effects of imidacloprid in laboratory animals. Investigations, conducted mostly on laboratory rats, have shown adverse effects of imidacloprid on the reproductive ability in both parental and offspring generation as well as on the development of the offspring. Like many pesticides, imidacloprid may also act as endocrine disrupting chemical (EDC). It may disrupt the metabolic homeostasis, contribute to obesity, and disrupt steroidogenesis by inhibiting cytochrome P450 (CYP) enzyme activities. All these adverse effects of imidacloprid may pose a serious risk for reproduction and development with long-term consequences in adulthood.

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supporting

confidence: 59%

Imidacloprid as reproductive toxicant and endocrine disruptor: investigations in laboratory animals

Mikolić

Karačonji

2018

Archives of Industrial Hygiene and Toxicology

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“…As imidacloprid increased in the spleen, we noted that FT4 levels and spleen size decreased. As stated previously, imidacloprid has been shown to decrease FT4 levels in other vertebrates 49 – 51 . Additionally, research on rats has shown that organ weights (specifically liver and spleen) decrease as imidacloprid treatment increases 54 – 56 .…”

Section: Discussionsupporting

confidence: 59%

“…Fawn and adult female FT3 values were similar to those reported in other studies, but FT4 results were elevated compared to previous studies 27 , 46 – 48 . We do not believe that this was the result of imidacloprid, as this pesticide decreases thyroid function in rats 49 , Indian wild birds 50 , and fish 51 . Rather, the elevated FT4 values may be due to a combination of pregnancy in adult females, the time of year, and artificial feed.…”

Section: Discussionmentioning

confidence: 95%

Effects of Neonicotinoid Insecticides on Physiology and Reproductive Characteristics of Captive Female and Fawn White-tailed Deer

Berheim

Jenks

Lundgren

et al. 2019

Sci Rep

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Over the past decade, abnormalities have been documented in white-tailed deer (Odocoileus virginianus) in west-central Montana. Hypotheses proposed to explain these anomalies included contact with endocrine disrupting pesticides, such as imidacloprid. We evaluated the effects of imidacloprid experimentally at the South Dakota State University Wildlife and Fisheries Captive Facility where adult white-tailed deer females and their fawns were administered aqueous imidacloprid (an untreated control, 1,500 ng/L, 3,000 ng/L, and 15,000 ng/L). Water consumption, thyroid hormone function, behavioral responses, and skull and jawbone measurements were compared among treatments. Additionally, liver, spleen, genital, and brain imidacloprid concentrations were determined by an enzyme-linked immunosorbent assay (ELISA). Results indicated that 1) control deer consumed more water than treatment groups, 2) imidacloprid was present in the organs of our control group, indicating environmental contamination, 3) as imidacloprid increased in the spleen, fawn survival, thyroxine levels, jawbone lengths, body weight, and organ weights decreased, 4) adult female imidacloprid levels in the genitals were negatively correlated with genital organ weight and, 5) behavioral observations indicated that imidacloprid levels in spleens were negatively correlated with activity levels in adult females and fawns. Results demonstrate that imidacloprid has direct effects on white-tailed deer when administered at field–relevant doses.

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“…76 Positive correlations were also observed between of-IMI and uric acid (UA, β = 0.040 μmol/L, 95%CI: 0.006, −0.074) and urea (β = 0.041 mmol/L, 95%CI: 0.000, 0.081) in MS, similar to that found in exposed rats. 77 These results suggest that of-IMI is hepatotoxic and nephrotoxic. 78 In MS, IMI was also associated with reduced albumin (ALB, β = −0.010 g/L, 95%CI: −0.019, −0.001).…”

Section: Chemicals Andmentioning

confidence: 86%

Neonicotinoid Insecticides and Their Metabolites Can Pass through the Human Placenta Unimpeded

Zhang

Bai

Zhang

et al. 2022

Environ. Sci. Technol.

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Studies on neonicotinoid (NEO) exposure in pregnant women and fetuses are scarce, and transplacental transfer of these insecticides is unknown. In this study, parent NEOs (p-NEOs) and their metabolites (m-NEOs) were determined in 95 paired maternal (MS) and cord serum (CS) samples collected in southern China. Imidacloprid was the predominant p-NEO in both CS and MS samples, found at median concentrations of 1.84 and 0.79 ng/mL, respectively, whereas N-desmethylacetamiprid was the most abundant m-NEO in CS (median: 0.083 ng/mL) and MS (0.13 ng/mL). The median transplacental transfer efficiencies (TTEs) of p-NEOs and m-NEOs were high, ranging from 0.81 (thiamethoxam, THM) to 1.61 (olefinimidacloprid, of-IMI), indicating efficient placental transfer of these insecticides. Moreover, transplacental transport of NEOs appears to be passive and structuredependent: cyanoamidine NEOs such as acetamiprid and thiacloprid had higher TTE values than the nitroguanidine NEOs, namely, clothianidin and THM. Multilinear regression analysis revealed that the concentrations of several NEOs in MS were associated significantly with hematological parameters related to hepatotoxicity and renal toxicity. To our knowledge, this is the first analysis of the occurrence and distribution of NEOs in paired maternal−fetal serum samples.

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Effect of Imidacloprid and Tetraconazole on Various Hematological and Biochemical Parameters in Male Albino Rats (Rattus Norvegious)

Cited by 4 publications

References 39 publications

Imidacloprid as reproductive toxicant and endocrine disruptor: investigations in laboratory animals

Imidacloprid as reproductive toxicant and endocrine disruptor: investigations in laboratory animals

Effects of Neonicotinoid Insecticides on Physiology and Reproductive Characteristics of Captive Female and Fawn White-tailed Deer

Neonicotinoid Insecticides and Their Metabolites Can Pass through the Human Placenta Unimpeded

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