Effect of <i>Enterococcus faecium</i> SF68 on serum cobalamin and folate concentrations in healthy dogs

Lucena, R.; Olmedilla, A. B.; Blanco, B.; Novales, M.; Ginel, Pedro J.

doi:10.1111/jsap.12845

Cited by 8 publications

(10 citation statements)

References 19 publications

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“…Failure to absorb cobalamin in dogs with EPI might be caused by 4 postulated or hypothetical mechanisms: pancreatic secretion of IF is reduced or absent, digestive enzymes are lacking causing an impaired release of cobalamin from haptocorrin and thus no binding of cobalamin to IF, secondary SI dysbiosis compromising the endogenous production of cobalamin, and the intestinal mucosa might also be compromised by the presence of toxic metabolites due to SI dysbiosis . However, in people cobalamin assimilation does not improve with antibiotic treatment, and there is no data that demonstrate a benefit of probiotics (eg, Enterococcus faecium SF68) or prebiotics.…”

Section: Conditions Associated With a Suboptimal Cobalamin Statusmentioning

confidence: 99%

Review of cobalamin status and disorders of cobalamin metabolism in dogs

Kather¹,

Grützner

Kook

et al. 2019

Veterinary Internal Medicne

105

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Disorders of cobalamin (vitamin B 12 ) metabolism are increasingly recognized in small animal medicine and have a variety of causes ranging from chronic gastrointestinal disease to hereditary defects in cobalamin metabolism. Measurement of serum cobalamin concentration, often in combination with serum folate concentration, is routinely performed as a diagnostic test in clinical practice. While the detection of hypocobalaminemia has therapeutic implications, interpretation of cobalamin status in dogs can be challenging. The aim of this review is to define hypocobalaminemia and cobalamin deficiency, normocobalaminemia, and hypercobalaminemia in dogs, describe known cobalamin deficiency states, breed predispositions in dogs, discuss the different biomarkers of importance for evaluating cobalamin status in dogs, and discuss the management of dogs with hypocobalaminemia. K E Y W O R D S cobalamin deficiency, cubam receptor, folate, homocysteine, hypercobalaminemia, hypocobalaminemia, methylmalonic acid, vitamin B 12

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Section: Conditions Associated With a Suboptimal Cobalamin Statusmentioning

confidence: 99%

Review of cobalamin status and disorders of cobalamin metabolism in dogs

Kather¹,

Grützner

Kook

et al. 2019

Veterinary Internal Medicne

105

View full text Add to dashboard Cite

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“…A randomized, blinded, controlled study was performed using serum samples obtained from dogs as a separate part of a previously published study about the effect of E. faecium SF68 on serum cobalamin and folate concentrations in healthy dogs . Briefly, 36 healthy privately owned neutered dogs were enrolled in the study.…”

Section: Methodsmentioning

confidence: 99%

“…A balanced diet for adult dogs (Brekkies, Affinity Petcare, SA, Spain) was given to all dogs twice daily for 2 weeks before the study and during the study to eliminate the effect of diet on serum biochemical variables and gut microbiota composition . Owners having >1 dog living in the same house were instructed to feed the dogs separately.…”

Section: Methodsmentioning

confidence: 99%

“…After an 18‐hour fast, a blood sample was taken by venipuncture from each dog at 3 different time points: day 1 (when starting the probiotic administration), day 14 (when the probiotic administration ended), and day 28 (2 weeks later). All serum samples were harvested immediately and frozen at −20°C until analyzed.…”

Section: Methodsmentioning

confidence: 99%

“…Enterococcus faecium SF68 is a commercially available probiotic product approved for use in dogs. It has been reported to induce variations in serum folate and cobalamin concentrations in healthy dogs, but its effect on liver function tests has not been studied.…”

Section: Introductionmentioning

confidence: 99%

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Effect of probiotic Enterococcus faecium SF68 on liver function in healthy dogs

Lucena

Novales

Blanco

et al. 2019

Veterinary Internal Medicne

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BackgroundProbiotics are widely used in dogs but can be associated with alterations in some serum biochemistry test results.ObjectiveTo assess the effect of Enterococcus faecium SF68 administration for 14 days on serum alanine transferase (ALT) and alkaline phosphatase (ALP) activity and total cholesterol and triglyceride concentrations in healthy dogs.AnimalsThirty‐six healthy privately owned neutered dogs were randomly allocated, stratified by sex, to control or probiotic groups. Dogs were clinically healthy, with normal physical examination findings, blood, urine, and fecal analyses and ultrasonographic examinations.MethodIn this blinded, controlled study E. faecium SF68 was administered to the probiotic group for 14 days. Blood samples were taken from all dogs at days 0, 14, and 28. Serum ALT and ALP activity and total cholesterol and triglyceride concentrations were determined on these 3 days.ResultsThe probiotic induced no significant changes in mean ALT and ALP activity. Mean cholesterol concentration did not change during probiotic administration but a significant decrease was seen on day 28 (P < .01). Mean triglyceride concentration increased progressively, becoming significant at day 28 (P < .05), with 1 dog developing hypertriglyceridemia.Conclusions and Clinical Importance E. faecium SF68 would not create confusion when monitoring dogs with hepatobiliary disease because ALT and ALP activity did not change significantly. A significant decrease in cholesterol and significant increase in triglyceride concentrations were seen at day 28 but were not clinically relevant, with 1 dog showing hypertriglyceridemia. A longer trial is warranted to assess if the probiotic effects could be clinically relevant and to assess its potential use in hypertriglyceridemic dogs.

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