Effect of Hyperventilation on the Excitability of the Motor Cortex in Cats

Concentration of carbon dioxide, interstitial pH and synaptic transmission in hippocampal formation of the rat.

“…Foerster (1924) also noted that in surgical patients hyperventilation lowered the threshold to electric stimulation of the exposed motor cortex. DeFinis (1932) and Brody & Dusser de Barenne (1932) have shown the same in experimental animals. Other investigators found that hypercapnia of experimental animals usually results in depression of synaptic transmission and of neuronal firing, although biphasic and excitatory effects have also been reported, especially for neurones involved in respiratory control (Kirstein, 1951; Krnjevic, Randic & Siesj6, 1965;Cohen 1968;Papajewski, Klee & Wagner, 1969;Caspers & Speckmann, 1974;Carpenter, Hubbard, Humphrey, Thompson & Marshall, 1974).…”

Concentration of carbon dioxide, interstitial pH and synaptic transmission in hippocampal formation of the rat.

“…Foerster (1924) also noted that in surgical patients hyperventilation lowered the threshold to electric stimulation of the exposed motor cortex. DeFinis (1932) and Brody & Dusser de Barenne (1932) have shown the same in experimental animals. Other investigators found that hypercapnia of experimental animals usually results in depression of synaptic transmission and of neuronal firing, although biphasic and excitatory effects have also been reported, especially for neurones involved in respiratory control (Kirstein, 1951; Krnjevic, Randic & Siesj6, 1965;Cohen 1968;Papajewski, Klee & Wagner, 1969;Caspers & Speckmann, 1974;Carpenter, Hubbard, Humphrey, Thompson & Marshall, 1974).…”

Concentration of carbon dioxide, interstitial pH and synaptic transmission in hippocampal formation of the rat.

“…Foerster (1924) also noted that in surgical patients hyperventilation lowered the threshold to electric stimulation of the exposed motor cortex. DeFinis (1932) and Brody & Dusser de Barenne (1932) have shown the same in experimental animals. Other investigators found that hypercapnia of experimental animals usually results in depression of synaptic transmission and of neuronal firing, although biphasic and excitatory effects have also been reported, especially for neurones involved in respiratory control (Kirstein, 1951; Krnjevic, Randic & Siesj6, 1965;Cohen 1968;Papajewski, Klee & Wagner, 1969;Caspers & Speckmann, 1974;Carpenter, Hubbard, Humphrey, Thompson & Marshall, 1974).…”

Concentration of carbon dioxide, interstitial pH and synaptic transmission in hippocampal formation of the rat.

“…Foerster (1924) also noted that in surgical patients hyperventilation lowered the threshold to electric stimulation of the exposed motor cortex. DeFinis (1932) and Brody & Dusser de Barenne (1932) have shown the same in experimental animals. Other investigators found that hypercapnia of experimental animals usually results in depression of synaptic transmission and of neuronal firing, although biphasic and excitatory effects have also been reported, especially for neurones involved in respiratory control (Kirstein, 1951; Krnjevic, Randic & Siesj6, 1965;Cohen 1968;Papajewski, Klee & Wagner, 1969;Caspers & Speckmann, 1974;Carpenter, Hubbard, Humphrey, Thompson & Marshall, 1974).…”