Effect of human umbilical cord blood derived lineage negative stem cells transplanted in amyloid-β induced cognitive impaired mice

Effects of mesenchymal stem cells transplantation on cognitive deficits in animal models of Alzheimer’s disease: A systematic review and meta‐analysis

“…What’s more, five studies reported the impact of MSC transplantation on increasing time in target quadrant compared with the control group. (Banik et al., ; Kim et al., ; Peng et al., ; Yang, Yang, et al., ), and the data indicated significant effectiveness of MSCs compared with the control group (SMD = 1.06, 95% CI = 0.46 to 1.67, p = .0005. heterogeneity, I 2 = 61%, p = .04) (Figure c).…”

“…Of these, 32 met our inclusion criteria and then 23 studies were excluded due to inadequate reporting of data that is required to calculate summary‐effect measure outcome. Therefore, nine studies investigating the therapeutic effect of MSCs on cognitive deficits in AD animal models were included in the meta‐analysis (Banik, Prabhakar, Kalra, & Anand, ; Cui et al., ; Fengxian, Wm, & Ling, ; Kim et al., ; Lee et al., ; Lee, Lee, et al., ; Li, Rilong, & Yue, ; Yang, Yang, et al., ; Yang, Yue, et al., ). The published studies range from 2010 to 2017.…”

“…The effects of MSC transplantation on cognitive deficits in AD models using the MWM test were examined in nine comparisons of nine included studies involving 225 animals. Nine studies reported the effect of MSC transplantation on decreasing escape latency compared with the control group (Banik et al., ; Cui et al., ; Fengxian et al., ; Kim et al., ; Lee et al., ; Li et al., ; Peng, Xing, Yang, Wang, & Wang, ; Yang, Yang, et al., ; Yang, Yue, et al., ).The pooled analysis indicated significant effectiveness in the ability of learning through measurements of the escape latency, which was the time that the mice in the maze successfully found the hidden platform (SMD = −0.99, 95% CI = −1.33 to −0.64, p <.00001). There was no heterogeneity among studies ( I 2 = 29%, p = .19) (Figure a).…”

“…Additionally, six studies reported the impact of MSC transplantation on increasing number of platform crossing compared with the control group (Banik et al., ; Cui et al., ; Fengxian et al., ; Kim et al., ; Li et al., ; Peng et al., ; Yang, Yang, et al., ; Yang, Yue, et al., ). We observed that transplantation of MSCs significantly increased the number of platform crossing in six experiments (SMD = 0.78, 95% CI = 0.43 to 1.13, p < .0001).The outcome that had no heterogeneity ( I 2 = 14%, p = .32) was observed across the studies (Figure b).…”

Short-Lived Human Umbilical Cord-Blood-Derived Neural Stem Cells Influence the Endogenous Secretome and Increase the Number of Endogenous Neural Progenitors in a Rat Model of Lacunar Stroke

“…It has been also postulated by other authors that human cord-blood-isolated stem cells can exert neuroprotective effects either through inhibiting apoptosis or through the production of trophic factors in amyloid-β-induced cognitively impaired mice [31]. In the current study, we investigated whether this increase in neurogenesis is also present after intracerebral transplantation of HUCB-NSCs, and whether it is facilitated by the extracellular matrix changes induced by metalloproteinase activity (MMP).…”