Effect of human leukocyte antigen class II genes on acute-onset and slow-onset type 1 diabetes in the Japanese population

Katahira, Masahito; Segawa, Satoko; Maeda, Harumi; Yasuda, Yoshinori

doi:10.1016/j.humimm.2010.05.020

Cited by 14 publications

(27 citation statements)

References 27 publications

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“…Table 3 shows previous reports on the relationship between HLA class II and AITD. The most probable HLA-DR and -DQ haplotypes were deduced from linkage disequilibria [8][9][10]. Alleles in parentheses following the reference number indicate that the reference reported susceptibility or resistance of the allele, but not the haplotype, to the disease.…”

Section: Aitdmentioning

confidence: 99%

“…Effect on T1D is classified as: S, susceptible; N, neutral; P, protective. These haplotypes are the major haplotypes which confer susceptibility to T1D in East Asians, especially in the Japanese population where the DR3 haplotype is absent and the DR4 haplotype is rare [8][9][10]. While these haplotypes encode Asp at position 57 of the DQβ1 chain, they confer susceptibility to T1D+AITD.…”

Section: Relationship Between T1d±aitd and Amino Acidmentioning

confidence: 99%

“…In the Japanese population, in contrast to Caucasians and other Asians, the DRB1*04:05-DQA1*03:03-DQB1*04:01 haplotype, which differs from the DR4 haplotype in Caucasians, and the DRB1*08:02-DQA1*03:01-DQB1*03:02, DRB1*09:01-DQA1*03:02-DQB1*03:03 (DR9), and DRB1*13:02-DQA1*01:02-DQB1*06:04 (DR13) haplotypes confer susceptibility to T1D [9,19]. The DRB1*15:01-DQB1:06:02, DRB1*15:02-DQB1*06:01, and DRB1*08:03-DQB1*06:01 haplotypes confer protection against T1D [9,10,19].…”

Section: Introductionmentioning

confidence: 99%

“…DRB1*15-DQB1*06:02 and DRB1*07:01-DQA1*02:01 (DR7) haplotypes confer strong protection against both T1D [2,3] and AITD [6,7]. However, in the Japanese population, the DR3 haplotype is absent, and the DR4 and DR7 haplotypes are rare [8][9][10], which may be more helpful for examining the susceptibility and resistance to T1D and AITD of HLA DR-DQ haplotypes, with the exception of DR3, DR4, and DR7. DR3 and DR4 haplotypes occur very frequently among Caucasian patients with T1D, and only a small percentage (approximately 10%) of Caucasian patients with T1D carry neither of these haplotypes [11,12].…”

Section: Introductionmentioning

confidence: 99%

“…The DRB1*15:01-DQB1:06:02, DRB1*15:02-DQB1*06:01, and DRB1*08:03-DQB1*06:01 haplotypes confer protection against T1D [9,10,19]. On the other hand, the DRB1*08:03-DQB1*06:01 and DR9 haplotypes confers susceptibility to AITD [19][20][21][22][23], whereas the DR13 and DRB1*15:01-DQB1:06:02 haplotypes confer protection against AITD [7,[23][24][25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

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The Relationship Between Human Leukocyte Antigen Class II Genes and Type 1 Diabetes, Autoimmune Thyroid Diseases, and Autoimmune Polyendocrine Syndrome Type 3

Katahira¹

2014

HLA and Associated Important Diseases

Self Cite

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Section: Aitdmentioning

confidence: 99%

Section: Relationship Between T1d±aitd and Amino Acidmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Relationship Between Human Leukocyte Antigen Class II Genes and Type 1 Diabetes, Autoimmune Thyroid Diseases, and Autoimmune Polyendocrine Syndrome Type 3

Katahira¹

2014

HLA and Associated Important Diseases

Self Cite

View full text Add to dashboard Cite

Past, present and future of latent autoimmune diabetes in adults

Liu

Xiang

Liu

et al. 2019

Diabetes Metabolism Res

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SummaryLatent autoimmune diabetes in adults (LADA) is the most common form of autoimmune diabetes diagnosed in adults. Similar to type 1 diabetes, the prevalence of LADA is impacted by ethnicity and geography. LADA is characterized by β cell loss due to autoimmunity and insulin resistance and has highly heterogeneous clinical features, autoimmunity, and genetics in a glutamic acid decarboxylase antibody (GADA) titre‐dependent manner, suggesting LADA is part of a continuum spectrum between type 1 and type 2 diabetes. Although LADA is the most frequent form of autoimmune diabetes diagnosed in adults, clinical trials involving LADA are scarce. Here we review the recent advancements in LADA epidemiology, clinical features, pathogenesis, and interventions. We also highlight the environmental factors that are thought to play an important role in addition to genetics in the pathogenesis of LADA. In the future, high‐throughput molecular profiles might shed light on the nature of LADA among the wide spectrum of diabetes and offer new opportunities to identify novel LADA‐specific biomarkers.

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Fulminant type 1 diabetes: A comprehensive review of an autoimmune condition

Luo

et al. 2020

Diabetes Metabolism Res

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Summary Fulminant type 1 diabetes (FT1D) is a subset of type 1 diabetes characterized by extremely rapid pancreatic β‐cell destruction with aggressive progression of hyperglycaemia and ketoacidosis. It was initially classified as idiopathic type 1 diabetes due to the absence of autoimmune markers. However, subsequent studies provide evidences supporting the involvement of autoimmunity in rapid β‐cell loss in FT1D pathogenesis, which are crucial for FT1D being an autoimmune disease. This article highlights the role of immunological aspects in FT1D according to the autoimmune‐associated genetic background, viral infection, innate immunity, adaptive immunity, and pancreas histology.

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Effect of human leukocyte antigen class II genes on acute-onset and slow-onset type 1 diabetes in the Japanese population

Cited by 14 publications

References 27 publications

The Relationship Between Human Leukocyte Antigen Class II Genes and Type 1 Diabetes, Autoimmune Thyroid Diseases, and Autoimmune Polyendocrine Syndrome Type 3

The Relationship Between Human Leukocyte Antigen Class II Genes and Type 1 Diabetes, Autoimmune Thyroid Diseases, and Autoimmune Polyendocrine Syndrome Type 3

Past, present and future of latent autoimmune diabetes in adults

Fulminant type 1 diabetes: A comprehensive review of an autoimmune condition

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