Effect of HPV-80 Rubella Vaccine on the Tuberculin Reaction

Cell mediated immunity in experimental rubella infections

“…Some have found a marked decrease of cellular immunity after congenital rubella (3) and others have reported a dewession of tuberculin test reactivity after vaccination with Cendehill virus (7). Some have found a marked decrease of cellular immunity after congenital rubella (3) and others have reported a dewession of tuberculin test reactivity after vaccination with Cendehill virus (7).…”

“…Several authors have recently reported a depression of skin test reactivity and of in vitro lymphocyte function after rubella vaccination (7,11). I-Iowever, LALLA et al were unable to confirm these findings (6).…”

Variable effect of encephalomyocarditis virus on host defense mechanisms

“…Measles virus, for example, diminishes tuberculin skin reactivity in tuberculin-sensitive children (22). Similarly, several viral vaccines (measles, mumps, rubella, yellow fever) have been shown to depress tuberculin skin reactivity (1,9,10). More recently, in vitro methods have been used to study the influence ofviruses on cell-mediated immunity.…”

Inhibition by interferon of delayed-type hypersensitivity in the mouse.

“…The classic observation in this field was made in 1907 by von Pirquet, who described a decreased reactivity to the tuberculin skin test as a result of infection with measles virus; it has since been repeatedly confirmed and studied in great detail (1). Moreover, depression of tuberculin sensitivity in man also occurs after infection with varicella, influenza, and rubella virus, as well as after vaccination with measles, polio, yellow fever, and mumps virus (2)(3)(4)(5)(6)(7)(8). Similar effects have been reported in animals; for example, using skin allograft survival as a measure of cell-mediated immunity, Howard et al showed that graft survival times were significantly prolonged in mice infected with lactic dehydrogenase virus shortly before or after grafting, and there are many other examples of immunodepression in animals after virus infection (9)(10)(11).…”