Effect of Hormones of the Sex Glands on Acne

Endocrine Factors in Acne Vulgaris.

“…305, 306, 307. 326) and regarding it as useless (323,340). Others believe that it is helpful in certain cases (5, 40, 71.…”

Endocrine Factors Tn Acne Vulgarts.

“…Wolfe (347) advises its use when gonadotropic hormone excretion is low. The results are apt to be variable (5,234,256,316,323) and relapses are common (316). Evaux (86) treated a number of cases for 5 months ; all of them showed initial improvement with paling and absorption of the smaller papules and decrease in the pustules.…”

“…Oestrogens.-The reports on the results of treatment with the oestrogens are as variable as those with the gonadotropic hormones; good (3,11,22,114,130,145,146,157,162,192,204,257,263,274,320,327,332,336,350,354), variable (121, 281,312,323), and poor (79,161,196,252,275,276,300,311) are reported. Some writers like Gerson (97) and Andrews (5) recommend that ovarian treatment should be given when specially indicated.…”

“…Combined gonadotropic hormone and oestrogen.-A few workers have used the gonadotropic and follicular hormones together (16,233,234,323,324,346). Varga (324) regards one type of acne as due to " menstruatio tarda,'' which may be due to hypofunction of the whole ovary.…”

“…Combined androgenic and gonadotropic hormones.-Va>n Studdiford (323) found that treatment with orchitic extract by mouth and gonadotropic hormone gave variable results. Wolfe (346) recommends that prolan with androgen and thyroid should be given to some children Avith acne, despite the fact that he believes the eruption may be due to excess of androgen over oestrogen secretion in the body.…”