Effect of Honey inPseudomonas aeruginosaInduced Stromal Keratitis in Rabbits

Abstract

To evaluate the healing effect of honey in Pseudomonas aeruginosa induced keratitis, 26 eyes of 26 white New Zealand Rabbits were experimentally infected with P. aeruginosa. Ten eyes were treated with a 90% concentration of natural honey, 10 with topical 0.3% ciprofloxacin and 6 eyes were left untreated. After one week, the eyes were enucleated and evaluated clinically and microscopically. All corneas showed a n opaque stromal infiltration at least 20 h post injection with progressive expansion only in the untreated group. There were no significant differences i n clinical signs between honey and ciprofloxacin groups while hypopyone formation and clinical infiltration were greater in the control group. Cellular infiltration and density of organism were comparable i n the two groups. Corneal perforation was found to be greater in the control group. It is concluded that, topical application of honey may be as effective as ciprofloxacin in P. aeroginosa induced keratitis.

Clinical and Antibacterial Effects of Tualang Honey on Pseudomonas-induced Keratitis in Rabbit Eyes

“…However, we found that there was a similar treatment benefit in all three groups with a reduction of median CFU on day seven. This finding is inconsistent with the study done by Nejabat et al who found that topical 90% concentrated natural honey was equally effective as ciprofloxacin 0.3% at treating Pseudomonas-induced keratitis in rabbit eyes and that both treatments led to a significant reduction in the number of bacteria compared to controls [23].…”

Standardised antibacterial Manuka honey in the management of persistent post‐operative corneal oedema: a case series

“…Medically regulated pure antibacterial honeys may have numerous practical advantages when used in corneal disease. These include a rapid clinical effect (Figures , and ), preservative‐free, long shelf‐life, unaffected by UV, storage at room temperature, low relative cost and relative abundance . Pure, raw honey is non‐toxic to the ocular surface, even with chronic use on a compromised ocular surface and allergy to honey is rare .…”

“…These include a rapid clinical effect (Figures 1, 2 and 3), preservative-free, long shelf-life, unaffected by UV, storage at room temperature, low relative cost and relative abundance. [1][2][3][4][5][6][7][8][9][10][11][12][13] Pure, raw honey is non-toxic to the ocular surface, even with chronic use on a compromised ocular surface 4,6,7 and allergy to honey is rare. [1][2][3] High-efficacy antibacterial Leptospermum spp.…”

“…Honey from a variety of floral sources and geographic locations and in a range of concentrations, has been reported as an effective adjunctive treatment in the management of chronic ocular surface disease, including Sjögren's and non‐Sjögren's aqueous deficient dry eye (ADDE), meibomian gland dysfunction (MGD), herpes zoster‐related neurotrophic keratitis, contact lens‐related bacterial keratitis and as an antimicrobial prophylaxis for ocular surgery . In animal models, unprocessed honey demonstrated equivalent efficacy to conventional antibiotic therapies in the management of Staphylococcus aureus and Pseudomonas aeruginosa conjunctivitis and keratitis …”

“…8 In animal models, unprocessed honey demonstrated equivalent efficacy to conventional antibiotic therapies in the management of Staphylococcus aureus and Pseudomonas aeruginosa conjunctivitis and keratitis. [9][10][11] Honey was used in the management of a series of cases of corneal epithelial oedema and bullous keratopathy unsuitable for corneal grafting. 12,13 Application of a drop of a pure raw local honey produced an immediate, complete, temporary clearing of the epithelial oedema lasting approximately one hour.…”