Effect of Homocysteine-Induced Oxidative Stress on Endothelial Function in Coronary Slow-Flow

Tanrıverdi, Halil; Evrengül, Harun; Enli, Yaşar; Kuru, Ömür; Şeleci, Deniz; Tanrıverdi, Seyhan; Tüzün, Nurullah; Kaftan, H. Asuman; Karabulut, Nevzat

doi:10.1159/000099068

Cited by 50 publications

(63 citation statements)

References 53 publications

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“…Zeiher et al [14] claimed that in the early phases of atherosclerosis or in the patients with intensive coronary artery disease risk factors before the development of angiographically documented atherosclerotic disease, vasodilation capacity of coronary resistive arterioles by pharmacologic and physical stress was disturbed. Recently, we reported that homocysteine induced oxidative stress may impair endothelial function in patients with SCF [15]. In another study, we demonstrated that carotid intima-media thickness which is the early sign of atherosclerosis is increased in SCF [16].…”

Section: Discussionmentioning

confidence: 99%

Simvastatin May Improve Myocardial Perfusion Abnormality in Slow Coronary Flow

et al. 2007

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Background: The slow coronary flow (SCF) phenomenon is a coronary microvascular disorder characterized by the delayed passage of contrast in the absence of obstructive epicardial coronary disease. Recent studies showed the possible role of endothelial dysfunction, diffuse atherosclerosis and inflammation in the pathogenesis of this phenomenon. We aimed to investigate the effect of statin on myocardial perfusion in patients with SCF. Methods and Results: The study population consisted of 97 patients with SCF. Coronary flow patterns of the cases are determined by thrombolysis in myocardial infarction (TIMI) frame count method. Single-photon emission computed tomographic myocardial perfusion imaging studies and lipid parameters of the patients were obtained before and after 6 months of simvastatin treatment period. During the study, daily single dose of 40 mg simvastatin has been given to each subject. We found a significant positive correlation between mean TIMI frame count and basal reversibility score (r = 0.84, p = 0.0001). In addition, analysis of the reversibility scores demonstrates that simvastatin treatment has significantly improved the myocardial perfusion abnormality at the end of the follow-up period. Conclusion: Present findings allow us to conclude that simvastatin improved myocardial perfusion in patients with SCF.

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Section: Discussionmentioning

confidence: 99%

Simvastatin May Improve Myocardial Perfusion Abnormality in Slow Coronary Flow

et al. 2007

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“…These evaluations were made individually and in case of any discrepancy reassessment was done by a third cardiologist. The slow and normal coronary flow pattern limits accepted in literature were 36.2±2.6 frame for LAD, 36.2±2.6 frame for CX, and 20.4±3 frame for RCA (15,16). In this study the TFC exceeding these limits are accepted as SCF.…”

Section: Study Variablesmentioning

confidence: 90%

“…With respect to our results, during the evaluation of usage of basal enzyme levels (with the exception of CAT) it is argued that patient group with highest oxidative stress can be classified as coronary slow flow group. In all studies demonstrating the role of oxidative stress in these two patient groups, groups are assessed separately (15)(16)(17)(18). This is the first study to evaluate syndrome X and coronary slow flow comparing the results with normal controls.…”

Section: Discussionmentioning

confidence: 99%

The effect of antioxidant enzyme levels and exercise on syndrome X and coronary slow flow phenomenon: an observational study

Kaplan¹,

Meriç²,

Acar³

et al. 2013

Anadolu Kardiyol Derg

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Objective: In this study the antioxidant enzyme [catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) ] levels at rest in patients with syndrome X and coronary slow flow are measured. Then it has been investigated whether there is any enzymatic difference between the normal controls and syndrome X patients or patients with coronary slow flow and ascertain if exercise has any effects on the antioxidant enzyme levels. Methods: Fifty-five patients were included in this prospective observational controlled study. Patients were divided into 3 groups: Group 1-normal controls (n=20); Group 2-patients with coronary slow flow (n=20); and Group 3-patients diagnosed with syndrome X (n=15). In all patients, blood samples were collected at rest and after maximal exercise. The antioxidant enzymes (SOD, CAT, Gpx) in the erythrocytes were studied for these three groups of blood sample. Statistical analysis was performed using Student t-test, Mann-Whitney U and Chi-square tests, KruskalWallis variance analysis and ANOVA. Results: Under basal conditions the lowest SOD and GPx levels were measured in the 2 nd Group, whereas significant differences in paired comparisons were observed only between the 2 nd and 3 rd Groups (p=0.024 vs. p<0.01, respectively) during paired comparisons. The postexercise SOD levels were decreased significantly in the 3 rd Groups when compared with the basal concentrations (p=0.014), however no significant pre-and post-exercise differences were observed in the CAT and GPx concentrations (p>0.05). Conclusion: The post-exercise SOD level when compared with basal SOD levels were decreased significantly in the syndrome X group, however no differences were observed between the other groups. This can be interpreted as the reduction in the exercise related symptoms and ischemic findings are resulting from the decrease of SOD activity. (Anadolu Kardiyol Derg 2013; 13: 641-6) Key words: Coronary slow flow, syndrome X, antioxidant enzymes Original Investigation Özgün Araşt›rma 641ÖZET Amaç: Bu çalışmada, sendrom X ve yavaş koroner akım hastalarında istirahatte antioksidan enzim [katalaz (CAT), süperoksid dismutaz (SOD) ve glutatyon peroksidaz (GPx)] düzeyleri ölçülerek normal kontrollerle fark gösterip göstermediği, egzersizin enzim düzeylerine etkisi olup olmadı-ğı araştırılmak istenmiştir.Yöntemler: Prospektif kontrollü gözlemsel bu çalışmaya 55 kişi alındı. Hastalar, normal kontroller (Grup 1, n= 20), koroner yavaş akımı olan hastalar (Grup 2, n=20) ve Sendrom X tanısı konan hastalar (Grup 3, n=15) olmak üzere 3 gruba ayrıldı. Tüm hastalardan istirahatte ve maksimum efor sonrası kanlar alındı ve eritrosit içindeki antioksidan enzimler (SOD, CAT, GPx) çalışıldı. İstatistiksel analiz Student t-testi, Mann-Whitney U, Ki-kare testi, Kruskal-Wallis varyans analizi ve ANOVA (post-hoc) kullanılarak yapıldı. Bulgular: Bazal şartlarda ölçülen SOD ve GPx değerleri en düşük olarak Grup 2'de saptanırken, ikili karşılaştırmada yalnızca Grup 2 ve 3 arasın-da anlamlı fark vardı (p sırasıyla 0,02...

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“…Lp(a) is involved in the adhesion of inflammatory cells and migration and uptake of macrophage foam cells into the arterial wall 12) , and the Lp(a) level is positively associated with CAD events 13) . Homocysteine is an intermediate metabolite of methionine that contributes to cardiovascular disease via mechanisms such as endothelial dysfunction, increased lipid permeability and vascular inflammation 14,15) . Hyperhomocysteinemia is an independent risk factor for PAD and CAD 16,17) .…”

Section: Introductionmentioning

confidence: 99%

High-sensitivity C-reactive Protein, Lipoprotein(a) and Homocysteine are Risk Factors for Coronary Artery Disease in Japanese Patients with Peripheral Arterial Disease

Kumakura

Fujita

Kanai

et al. 2015

JAT

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Aim:The goal of the study was to investigate the relationships between coronary artery disease (CAD) and risk factors, including the serum levels of high-sensitivity C-reactive protein (hs-CRP), lipoprotein(a) (Lp(a)) and homocysteine, in Japanese patients with peripheral arterial disease (PAD). Methods: Coronary angiography was performed in 451 patients with PAD, among whom the prevalence and clinical characteristics of CAD were analyzed. A multiple logistic analysis was used to evaluate the relationships between CAD and the risk factors. The relationships between the severity of coronary arterial lesions and the risk factors were evaluated using multiple regression analysis. Results: The prevalence of CAD (≥ 70% luminal diameter narrowing or a history of CAD) and coronary artery stenosis (≥ 50%) was 55.9% and 74.1%, respectively, and the rate of CAD (≥ 70%) with single-, double-and triple-vessel disease was 25.9%, 13.5% and 10.6%, respectively. The prevalence of diabetes was higher among the patients with CAD than among those without. The serum levels of hs-CRP, Lp(a), and homocysteine were higher in the patients with CAD, whereas the estimated glomerular filtration rates and HDL-cholesterol levels were lower in these patients. According to the multiple logistic analysis, CAD was related to diabetes (hazard ratio [

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Effect of Homocysteine-Induced Oxidative Stress on Endothelial Function in Coronary Slow-Flow

Cited by 50 publications

References 53 publications

Simvastatin May Improve Myocardial Perfusion Abnormality in Slow Coronary Flow

Simvastatin May Improve Myocardial Perfusion Abnormality in Slow Coronary Flow

The effect of antioxidant enzyme levels and exercise on syndrome X and coronary slow flow phenomenon: an observational study

High-sensitivity C-reactive Protein, Lipoprotein(a) and Homocysteine are Risk Factors for Coronary Artery Disease in Japanese Patients with Peripheral Arterial Disease

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