Effect of high-fat diet on cognitive impairment in triple-transgenic mice model of Alzheimer's disease

Sah, Saroj; Lee, Chan; Jang, Jung‐Hee; Park, Gyu Hwan

doi:10.1016/j.bbrc.2017.08.122

Cited by 100 publications

(84 citation statements)

References 28 publications

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“…Furthermore, TWD strongly increased fatty liver changes, emphasizing the robust effect of TWD on the metabolism of not only in the brain but also in peripheral tissues, as also shown previously [97]. Our results related to the behavioral assessments strongly suggest that TWD-induced obesity and diabetic phenotype impair memory and learning, which are also supported by the previous findings [24,26,33,34,38,47,81]. More specifically, the comparison of the four genotypes suggests that adverse effects of TWD on memory and learning are the most prominent in mice with a moderate genetic predisposition to develop AD-like brain pathology (A+Tw and AwT+), while in the A+T+ mice, the strong genetic burden overpowers the effect of TWD.…”

Section: Discussionsupporting

confidence: 90%

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Diabetic phenotype in mouse and humans with β-amyloid pathology reduces the number of microglia around β-amyloid plaques

Natunen

Martiskainen

Marttinen

et al. 2020

Preprint

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Section: Discussionsupporting

confidence: 90%

“…In mice, high-fat diet (HFD) and TWD lead to obesity, glucose intolerance and finally to full-blown T2D [101]. In most of the studies, HFD and TWD have led to impaired memory in both wild-type (WT) and AD transgenic mice [24,26,47,81]. Also, impaired insulin-Akt signaling in the brain of HFD/TWD animals has been often reported [34,48,73].…”

Section: Introductionmentioning

confidence: 99%

Diabetic phenotype in mouse and humans with β-amyloid pathology reduces the number of microglia around β-amyloid plaques

Natunen

Martiskainen

Marttinen

et al. 2020

Preprint

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“…In fact, preclinical experiments have confirmed that high fat diet (HFD) may change the gut microbiota and contribute to development of dementia (Studzinski et al, 2009;Nam et al, 2017;Sah et al, 2017;Sanguinetti et al, 2018). These studies demonstrated that HFD promoted cognitive impairment by inducing oxidative stress and deteriorative neuronal apoptosis via inactivation of Nrf2 signaling pathway (Studzinski et al, 2009;Nam et al, 2017;Sah et al, 2017;Sanguinetti et al, 2018). Nam and coauthors showed that HFD significantly increased amyloid deposition and reduced cognition of 12-months old APP23 mice (Nam et al, 2017).…”

Section: Unhealthy Nutrition Linked To Alzheimer's Disease and Gut MImentioning

confidence: 98%

“…For example, it has been demonstrated that AD rates increased from 1% in 1985 to 7% in 2008 in Japan, and this increase is associated with nutritional transition from the traditional Japanese diet to a Western diet (Dodge et al, 2012). In fact, preclinical experiments have confirmed that high fat diet (HFD) may change the gut microbiota and contribute to development of dementia (Studzinski et al, 2009;Nam et al, 2017;Sah et al, 2017;Sanguinetti et al, 2018). These studies demonstrated that HFD promoted cognitive impairment by inducing oxidative stress and deteriorative neuronal apoptosis via inactivation of Nrf2 signaling pathway (Studzinski et al, 2009;Nam et al, 2017;Sah et al, 2017;Sanguinetti et al, 2018).…”

Section: Unhealthy Nutrition Linked To Alzheimer's Disease and Gut MImentioning

confidence: 99%

The Links Between the Gut Microbiome, Aging, Modern Lifestyle and Alzheimer's Disease

Askarova

Umbayev

Masoud

et al. 2020

Front. Cell. Infect. Microbiol.

143

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Gut microbiome is a community of microorganisms in the gastrointestinal tract. These bacteria have a tremendous impact on the human physiology in healthy individuals and during an illness. Intestinal microbiome can influence one's health either directly by secreting biologically active substances such as vitamins, essential amino acids, lipids et cetera or indirectly by modulating metabolic processes and the immune system. In recent years considerable information has been accumulated on the relationship between gut microbiome and brain functions. Moreover, significant quantitative and qualitative changes of gut microbiome have been reported in patients with Alzheimer's disease. On the other hand, gut microbiome is highly sensitive to negative external lifestyle aspects, such as diet, sleep deprivation, circadian rhythm disturbance, chronic noise, and sedentary behavior, which are also considered as important risk factors for the development of sporadic Alzheimer's disease. In this regard, this review is focused on analyzing the links between gut microbiome, modern lifestyle, aging, and Alzheimer's disease.

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“…Feeding mouse models of neurodegenerative disease with diets that induce obesity is one approach to elucidating the mechanistic links between obesity and dementia. Feeding mice a western high-fat diet (Hfd) has been linked to impaired cognitive function in wild-type mice [12,13], as well as to more severe cognitive impairment in AD mouse models [14,15], with obesitylinked cognitive deficits most prominent in tests for short-term and working memory [16,17].…”

Section: Introductionmentioning

confidence: 99%

High fat diet worsens pathology and impairment in an Alzheimer’s mouse model, but not by synergistically decreasing cerebral blood flow

Bracko

et al. 2019

Preprint

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Obesity is linked to increased risk for and severity of Alzheimer's disease (AD). Cerebral blood flow (CBF) reductions are an early feature of AD and are also linked to obesity. We showed that non-flowing capillaries, caused by adhered neutrophils, underlie the CBF reduction in mouse models of AD. Because obesity could exacerbate the vascular inflammation likely underlying this neutrophil adhesion, we tested links between obesity and AD by feeding APP/PS1 mice a high fat diet (Hfd) and evaluating behavioral, physiological, and pathological changes. We found trends toward poorer memory performance in APP/PS1 mice fed a Hfd, impaired social interactions with either APP/PS1 genotype or a Hfd, and synergistic impairment of sensorymotor function in APP/PS1 mice fed a Hfd. The Hfd led to increases in amyloid-beta monomers and plaques in APP/PS1 mice, as well as increased brain inflammation. These results agree with previous reports showing obesity exacerbates AD-related pathology and symptoms in mice. We used a crowd-sourced, citizen science approach to analyze imaging data to determine the impact of the APP/PS1 genotype and a Hfd capillary stalling and CBF. Surprisingly, we did not see an increase in the number of non-flowing capillaries or a worsening of the CBF deficit in APP/PS1 mice fed a Hfd as compared to controls, suggesting capillary stalling is not a mechanistic link between a Hfd and increased severity of AD in mice. Reducing capillary stalling by blocking neutrophil adhesion improved CBF and short-term memory function in APP/PS1 mice, even when fed a Hfd. Keywords: animal behavior; nonlinear microscopy; brain blood flow; western high fat diet Significance statement:Obesity, especially in mid-life, has been linked to increased risk for and severity of Alzheimer's disease. Here, we show that blocking adhesion of white blood cells leads to increases in brain blood flow that improve cognitive function, regardless of whether mice are obese or not.

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Effect of high-fat diet on cognitive impairment in triple-transgenic mice model of Alzheimer's disease

Cited by 100 publications

References 28 publications

Diabetic phenotype in mouse and humans with β-amyloid pathology reduces the number of microglia around β-amyloid plaques

Diabetic phenotype in mouse and humans with β-amyloid pathology reduces the number of microglia around β-amyloid plaques

The Links Between the Gut Microbiome, Aging, Modern Lifestyle and Alzheimer's Disease

High fat diet worsens pathology and impairment in an Alzheimer’s mouse model, but not by synergistically decreasing cerebral blood flow

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