Effect of hesperetin on inflammatory and oxidative status in trinitrobenzene sulfonic acid-induced experimental colitis model

Polat, Fatin Rüştü; Karaboğa, İhsan; Polat, Muhammed Semih; Erboğa, Zeynep Fidanol; Yılmaz, Ahsen; Güzel, Savaş

doi:10.14715/cmb/2018.64.11.11

Cited by 25 publications

(15 citation statements)

References 55 publications

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“…In the current study, the levels of IL-1β and TNF-α increased following silica exposure, and the levels of these inflammatory factors decreased in the 400 mg/kg HSP group on the 28th day. Previous studies have also revealed that HSP can reduce the levels of TNF-α and IL-6, and protect TNBS-induced colitis model via its antioxidation, anti-inflammatory and anti-apoptotic effects (66). It is considered that HSP exhibits a protective effect on many diseases by exerting anti-inflammatory effects (67).…”

Section: Discussionmentioning

confidence: 99%

Hesperetin attenuates silica‑induced lung injury by reducing oxidative damage and inflammatory response

Shao

Fang

et al. 2021

Exp Ther Med

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Oxidative stress and the inflammatory response are two important mechanisms of silica-induced lung injury. Hesperetin (HSP) is a natural flavonoid compound that is found in citrus fruits and has been indicated to exhibit strong antioxidant and anti-inflammatory properties. The current study evaluated the protective effect of HSP on lung injury in rats exposed to silica. The results indicated that the degree of alveolitis and pulmonary fibrosis in the HSP-treated group was significantly decreased compared with the silica model group. The content of hydroxyproline (HYP) was also revealed to decrease overall in the HSP treated group compared with the silica model group, indicating that the degree of pulmonary fibrosis was decreased compared with the silica model group. The present study also demonstrated that HSP reduced oxidation levels of malondialdehyde (MDA) and increased the activities of antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-PX). Total antioxidant capacity (T-AOC) was also increased following HSP treatment, indicating that HSP can alleviate oxidative stress in the lung tissue of silica-exposed rats. In addition, HSP was revealed to inhibit the synthesis and secretion of fibrogenic factor TGF-β1, reduce the production of pro-inflammatory cytokines IL-1β, IL-4, TNF-α and increase the levels of anti-inflammatory factors IFN-γ and IL-10. The current study demonstrated that HSP can effectively attenuate silica-induced lung injury by reducing oxidative damage and the inflammatory response.

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Section: Discussionmentioning

confidence: 99%

Hesperetin attenuates silica‑induced lung injury by reducing oxidative damage and inflammatory response

Shao

Fang

et al. 2021

Exp Ther Med

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“…Hesperidin demonstrated antioxidant activity in rats after an intensive training program, and attenuated the secretion of cytokines by stimulated macrophages [67,68]. The administration of hesperetin has been shown to significantly reduce the levels of myeloperoxidase, malondialdehyde (a marker of lipid peroxidation) and inflammation in experimental models of colitis [69] and hepatic trauma [70]. In a model of rheumatic arthritis induced by Freund's complete adjuvant, hesperidin successfully reversed the signs and symptoms, inflammatory markers and lipid peroxidation [71].…”

Section: Antioxidant Activitymentioning

confidence: 99%

Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus Fruits

Bellavite

Donzelli²

2020

Antioxidants

159

140

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Among the many approaches to Coronavirus disease 2019 (COVID-19) prevention, the possible role of nutrition has so far been rather underestimated. Foods are very rich in substances, with a potential beneficial effect on health, and some of these could have an antiviral action or be important in modulating the immune system and in defending cells from the oxidative stress associated with infection. This short review draws the attention on some components of citrus fruits, and especially of the orange (Citrus sinensis), well known for its vitamin and flavonoid content. Among the flavonoids, hesperidin has recently attracted the attention of researchers, because it binds to the key proteins of the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several computational methods, independently applied by different researchers, showed that hesperidin has a low binding energy, both with the coronavirus “spike” protein, and with the main protease that transforms the early proteins of the virus (pp1a and ppa1b) into the complex responsible for viral replication. The binding energy of hesperidin to these important components is lower than that of lopinavir, ritonavir, and indinavir, suggesting that it could perform an effective antiviral action. Furthermore, both hesperidin and ascorbic acid counteract the cell damaging effects of the oxygen free radicals triggered by virus infection and inflammation. There is discussion about the preventive efficacy of vitamin C, at the dose achievable by the diet, but recent reviews suggest that this substance can be useful in the case of strong immune system burden caused by viral disease. Computational methods and laboratory studies support the need to undertake apposite preclinical, epidemiological, and experimental studies on the potential benefits of citrus fruit components for the prevention of infectious diseases, including COVID-19.

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“…[ 22,23,37,37,41 ] Interestingly, previous studies on the hesperetin effect on colitis showed similar results for TNF‐α, IL‐6, and NF‐κB. [ 42,43 ]…”

Section: Discussionmentioning

confidence: 72%

Cinnamaldehyde and hesperetin attenuate TNBS‐induced ulcerative colitis in rats through modulation of the JAk2/STAT3/SOCS3 pathway

Elhennawy

Abdelaleem

Zaki³

et al. 2021

J Biochem & Molecular Tox

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Ulcerative colitis is an autoimmune inflammatory disorder with a negative impact on the life quality of patients. Cinnamaldehyde and hesperetin were chosen due to their antioxidants and anti‐inflammatory effects. This study explored the protective effects of cinnamaldehyde (40 and 90 mg/kg, po) and hesperetin (50 and 100 mg/kg, po) on 2,4,6‐trinitrobenzene sulfonic acid (TNBS)‐induced ulcerative colitis in rats. Cinnamaldehyde and hesperetin significantly improved macroscopic and histopathological examinations with a significant reduction in myeloperoxidase and intracellular adhesion molecule‐1 expression. They significantly reduced colon oxidative stress by a significant elevation in both reduced glutathione content and superoxide dismutase activity with a significant reduction of NO content. Furthermore, cinnamaldehyde and hesperetin alleviated the inflammatory injury by a significant reduction in interleukin‐6 along with suppression of nuclear factor‐κB, receptor for advanced glycation end products, and tumor necrosis factor‐α expression. Moreover, cinnamaldehyde and hesperetin significantly decreased p‐JAK2 and p‐STAT3 while significantly increased suppressors of cytokine signaling 3 (SOCS3) protein expression. In conclusion, cinnamaldehyde and hesperetin counteracted TNBS‐induced ulcerative colitis through antioxidant, anti‐inflammatory properties as well as modulation of the JAk2/STAT3/SOCS3 pathway.

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Effect of hesperetin on inflammatory and oxidative status in trinitrobenzene sulfonic acid-induced experimental colitis model

Cited by 25 publications

References 55 publications

Hesperetin attenuates silica‑induced lung injury by reducing oxidative damage and inflammatory response

Hesperetin attenuates silica‑induced lung injury by reducing oxidative damage and inflammatory response

Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus Fruits

Cinnamaldehyde and hesperetin attenuate TNBS‐induced ulcerative colitis in rats through modulation of the JAk2/STAT3/SOCS3 pathway

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