1959
DOI: 10.1172/jci103978
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Sulfobromophthalein (BSP) clearance hasproved a sensitive index of hepatic function. Although dosage, sampling intervals and techniques of measurement have been modified (1)(2)(3)(4), the procedure remains essentially as originally described (5, 6). Basically it conisists of the intravenous injectioni of a stanidard amiiount of BSP and determination of residual BSP in the plasma from blood samples collected at prescriled intervals.Since clearanice of BSP is (lecreased 1)oth in hlepatocellular dysfunction anid … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

0
21
0

Year Published

1961
1961
1979
1979

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 66 publications
(21 citation statements)
references
References 14 publications
(14 reference statements)
0
21
0
Order By: Relevance
“…Equal volumes of plasma from each of the four plasma samples obtained during each hour of BSP infusion were pooled. BSP compounds were extracted from the pooled plasma and prepared for paper chromatography on Whatman 3MM paper as outlined by Carbone, Grodsky, and Hjelte (12). The chromatograms were developed in a descending system employing glacial acetic acid: water: n-propyl alcohol (1: 5: 10 by vol), for 16 to 18 hours.…”
Section: Methodsmentioning
confidence: 99%
“…Equal volumes of plasma from each of the four plasma samples obtained during each hour of BSP infusion were pooled. BSP compounds were extracted from the pooled plasma and prepared for paper chromatography on Whatman 3MM paper as outlined by Carbone, Grodsky, and Hjelte (12). The chromatograms were developed in a descending system employing glacial acetic acid: water: n-propyl alcohol (1: 5: 10 by vol), for 16 to 18 hours.…”
Section: Methodsmentioning
confidence: 99%
“…Liver function was examined in these patients by the following tests: per cent esterification of cholesterol, direct and indirect bilirubin, cephalin and thymol flocculations, thymol turbidity, prothrombin time, serum albumin and globulin, retention of BSP in plasma 45 Table II. BSP components in plasma obtained during comparable (i.e., plasma sampled at the same time in the same portion of the injection sequence) infusion periods were examined chromatographically (10,16,17) in 4 subjects as follows: 2 ml of plasma was extracted with approximately 10 ml acetone; the extract was dried in vacuo; the residue was redissolved in 0.5 ml distilled water, applied to a 5-cm strip on Whatman 1 paper, and that the chromatographic losses and optical densities of free and conjugated BSP were equal (17). The developed chromatograms from control and estradiol periods in 1 of the 4 subjects are shown in Figure 4.…”
Section: Methodsmentioning
confidence: 99%
“…It is clear, however, that conjugation is not essential for BSP secretion and that at least part of the BSP can be secreted in the free form. In liver disease the relative percentage of free BSP and various conjugates in bile, serum, and urine differs from the normal (6,7,12).…”
mentioning
confidence: 91%
“…It is clear, however, that conjugation is not essential for BSP secretion and that at least part of the BSP can be secreted in the free form. In liver disease the relative percentage of free BSP and various conjugates in bile, serum, and urine differs from the normal (6,7,12).Because the elimination of BSP is retarded in both full term (13-15) and premature infants (16-19) it seemed of interest to investigate the extent of BSP conjugation in these age groups. Because of the insufficient conjugation that leads to the diminished bilirubin excretion after birth (20, 21), a similar mechanism for the inadequate BSP clearance was considered possible.…”
mentioning
confidence: 99%
See 1 more Smart Citation