Effect of hemodialysis and transplantation on inhibition of lymphocyte transformation by sera from uremic patients

Nelson, D. S.; Penrose, Jean M.

doi:10.1016/0090-1229(75)90048-3

Cited by 15 publications

(4 citation statements)

References 8 publications

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“…Prednisone can inhibit a positive tuberculin test [5], The reduced de layed hypersensitivity response in the transplant group would, therefore, appear to be due to the immunosuppressive therapy and the reduced re sponse in the uraemic state pre-transplantation. A reduced response to PHA of lymphocytes cultured in uraemic serum or plasma has been al ready reported [14,21,32,33,41]. Contrary to one of these reports [21], a reduced lymphocyte response in the present study closely paralleled a reduction in the lymphocyte count and bore no relation to anergy.…”

Section: Discussioncontrasting

confidence: 55%

Defective Immune and Phagocytic Functions in Uraemia and Renal Transplantation

McIntosh

Hansen

Ziegler

et al. 1976

Int Arch Allergy Immunol

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The humoral, cellular and neutrophil responses of uraemic patients maintained by haemodialysis were compared with those of renal transplant recipients. Humoral immunity was reduced only in the transplant group. Cell-mediated immunity was abnormal in both groups but more decreased in the transplant group studied particularly within 3 months of transplantation. The neutrophil bactericidal capacities were defective in both groups. Infectious complications were often associated with defective cellular immunity, but fatal infections occurred only in transplant patients over 40 years of age with combined cellular and neutrophil defects. No single test was predictive of graft survival in uraemic patients. The depressed cellular immune responses in uraemia, of the degree seen in the immunosuppressed transplant recipient, may explain the better prognosis of renal transplants compared with other organ transplants.

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Section: Discussioncontrasting

confidence: 55%

Defective Immune and Phagocytic Functions in Uraemia and Renal Transplantation

McIntosh

Hansen

Ziegler

et al. 1976

Int Arch Allergy Immunol

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“…In contrast, in vitro response to SRBC was not affected by the uremic serum. These results agree with those of Nelson and Penrose [10] who immunized uremic and sham-operated rats with SRBC and showed a comparable in vivo immune response in both animal groups. Therefore, it is clear that the immune response in uremia depends on the antigen tested.…”

Section: Discussionsupporting

confidence: 83%

“…On the other hand, the intrinsic responsiveness of lymphocytes from uremic rats was sig nificantly lowered only in presence of uremic serum. Our data are in concordance with those of Klinger et al [9], Newberry and Sanford [4] and Nelson and Penrose [10] who reported the suppressive effect of uremic sera on the mitogen-induced proliferation of human lymphocytes and those of Raskova et al [11], who reported on inhibitory effect of sera from uremic rats in mixed lymphocyte re sponse. However, neither of these reports compared the immunosuppressive effects of uremia on both humoral and cellular factors at the same time.…”

Section: Discussionsupporting

confidence: 82%

Analysis of Humoral and Cellular Factors that Contribute to Impaired Immune Responsiveness in Experimental Uremia

Mezzano¹,

Aj²,

Pollak³

et al. 1984

Nephron

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An experimental model in rats was developed to define the nature of humoral and cellular factors that contribute to impaired immune responsiveness in chronic renal failure. Addition of uremic rat serum to both normal and uremic lymphocytes significantly suppressed cellular responses, the suppression being more pronounced with uremic lymphocytes. Lymphocytes from uremic rats were only marginally less responsive than normal lymphocytes to concanavalin A stimulation when normal rat serum was added to the cultures, indicating that the cellular factors in impairment were less important than humoral ones. Antibody formation in rat splenocyte cultures to bovine serum albumin was suppressed by addition of uremic serum, but the response to sheep erythrocytes was unaffected. Thus the effect on antibody response in uremic animals is dependent upon the antigen tested.

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“…At the present time, these alterations are only partially understood, despite the fact that profound suppression of cell-me diated responses has been widely observed. Some in vestigators report that peripheral blood lymphocytes (PBL) taken from renal failure patients are themselves defective [6][7][8][9][10], while others show that the suppres sive factors present in uremic serum are responsible for the observed suppression [11][12][13][14], It has been determined that patients on hemodialy sis have a high rate of infections [15][16][17], cutaneous anergy [18][19][20], altered response to hepatitis B infec tions [21][22][23][24][25][26][27], and an increased rate of malignancies [28][29][30][31][32][33]. Several studies have found the suppressive ef fect to be nondialyzable [9,10,27,34], while others have reported improvement after hemodialysis [13,14], Studies of the immune response in the uremic ani mal model have indicated that experimentally in duced renal failure has suppressive activity on the various parameters of CMI [35][36][37][38][39][40][41], Recent observa tions from our laborat...…”

Section: Introductionmentioning

confidence: 99%

The Role of Monocytes and Responder Cells in Suppression of Antigen-Specific T Cell Proliferation in Chronic Renal Failure

Alevy¹,

Mueller²,

Anderson³

et al. 1984

Int Arch Allergy Immunol

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The response of peripheral blood lymphocytes (PBL) to the antigen tetanus toxoid (TT) in patients with chronic renal failure being maintained on hemodialysis was examined. We have found that: (1) the response of patients’ unfractionated PBL to TT is markedly suppressed when compared to the response of control PBL; (2) the response of patients’ purified T cells and T4⁺ cells to TT co-cultured with 5% autologous monocytes is suppressed when compared to the response of comparable control cultures; (3) the response of patients’ purified T lymphocytes co-cultured with 5 % autologous monocytes is significantly enhanced over the response of patients’ unfractionated PBL, and (4) the suppressed proliferation of patients’ PBL to TT is not reversed by hemodialysis. Thus, the presence of suppressor monocytes and the inability of the responding T cells and accessory monocytes to react to antigen contribute to the suppressed antigen-specific T cell proliferation observed in chronic renal failure patients. These results are relevant to the suppressed cell-mediated immunity observed in uremia.

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Effect of hemodialysis and transplantation on inhibition of lymphocyte transformation by sera from uremic patients

Cited by 15 publications

References 8 publications

Defective Immune and Phagocytic Functions in Uraemia and Renal Transplantation

Defective Immune and Phagocytic Functions in Uraemia and Renal Transplantation

Analysis of Humoral and Cellular Factors that Contribute to Impaired Immune Responsiveness in Experimental Uremia

The Role of Monocytes and Responder Cells in Suppression of Antigen-Specific T Cell Proliferation in Chronic Renal Failure

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