Isothermal baryon-number fluctuations arising from a first-order quark-hadron phase transition in the early Universe are obtained by including the quark-gluon interactions up to the order gj in the perturbative QCD coupling constant in the quark-gluon plasma (QGP) phase and the finite-size volume corrections for the hadrons in the hadron-resonance gas (HRG) and their effects on the primordial nucleosynthesis (PNS) are analyzed. The ratio of the baryon-number densities in the QGP and HRG phases at the critical temperature T, is larger than one in the range 150 MeV < T, < 260 MeV. However, it is far larger than one even when T, is outside this range, thus affecting primordial nucleosynthesis significantly.PACS number(s1: 04.40. Dg, 12.38.Mh, 98.80.Ft The nature and the critical parameters of the phase transition between a hadron resonance gas (HRG) and the quark-gluon plasma (QGP) are the object of active theoretical and experimental research [1,2]. At very high temperatures in the early Universe, we believe that the colored quarks and gluons were unconfined and the matter existed in the form of a QGP. As the Universe expanded, the temperature dropped through the critical temperature Tc for the phase transition where the Q G P could exist in thermal, mechanical, and chemical equilibrium with a dense hot gas of H R G . Isothermal baryonnumber fluctuation is a natural consequence of a firstorder phase transition between a Q G P and HRG. Consequently, a large local fluctuation in the baryon-to-photon ratio results and thus alters the predictions of the standard scenario for primordial nucleosynthesis (PNS). The ratio of baryon-number densities in the two phases is represented by and the expression is evaluated at T = T c and baryon chemical potential p, <> 1, the baryon number of the Universe preferentially remained in the Q G P phase during the period of phase separation and thus affected the PNS significantly.Several authors have calculated [3-81 the value of R by assuming a Q G P as an ideal thermodynamical gas of quarks and gluons and the H R G was treated as an ideal gas of protons and neutrons. Turner [ 3 ] noticed that the ratio R decreases significantly when other low-lying baryon states, e.g., A (mass 1232 MeV, ~' = 3 / 2 ' and I = 3 / 2 ) , A, 2', zO, and 2 -(strangeness = -1 states) were included. H e found that unless Tc < 150 MeV, the effects of the phase transition upon PNS would not be significant. However, they found R << 1 for Tc > 250 MeV and that the baryon number resides predominantly in the H R G phase. Recently, Murugesan et al. [ 4 ] used relativistic quantum statistics for particles in both the phases and Hagedorn's correction for the finite size of the hadrons in the H R G phase. They found that these corrections lower the value of Tc and, unless Tc 5 125MeV and R > 10, the phase transition would not have any significant effect upon PNS. The purpose of this paper is to explore the results when a phase transition from a Q G P with interacting quarks and gluons to a hadron gas co...