Effect of Gua Sha therapy on patients with diabetic peripheral neuropathy: A randomized controlled trial

The Association of Elevated Serum Lipocalin-2 Levels With Diabetic Peripheral Neuropathy in Type 2 Diabetes

“…Additionally, we found that with the increase in serum LCN2 levels, the TCNS scores for DPN were increased (Fig 3). Application of TCNS in clinical studies has con rmed its role in documenting and monitoring DPN [14,21,22]. A higher score indicates more severe disability.…”

Exercise and Manual Therapy for Diabetic Peripheral Neuropathy: A Systematic Review

“…There were 16 articles that included patients aged over 40 years [22,[24][25][26]28,29,[33][34][35][36][37][38][39][40][41][42]. In addition, six articles included patients older than 18 [23,[43][44][45][46][47], while seven did not specify the age for the selection of their sample [27,[30][31][32][48][49][50].…”

“…There were 22 articles that included an intervention group with exercise [23,[25][26][27][28][29][30][31][32][33][34][36][37][38][39][40][41][42]46,47,49,50] and six articles included an intervention group with manual therapy [22,24,[43][44][45]48], while one article combined both interventions [35]. Blood analyses taking HbA1c as a reference (cut-off value ≥ 6.5%) and blood glucose levels (cut-off value ≥ 7.0 mmol/L or ≥120 mg/dL fasting value and ≥11.1 mmol/L or ≥200 mg/dL postprandial value); the Michigan questionnaire for neuropathies; and the American Diabetes Association criteria [50] were the criteria most used for the diagnosis of diabetic neuropathy.…”

“…There were 22 articles that included an intervention group with exercise [23,[25][26][27][28][29][30][31][32][33][34][36][37][38][39][40][41][42]46,47,49,50] and six articles included an intervention group with manual therapy [22,24,[43][44][45]48], while one article combined both interventions [35].…”

“…Thai-type massage [22], Gua Sha [43], reflexology [48] and aromatherapy [45] seem to be more effective in pain and function variables than the control group in patients with diabetic neuropathy. Treatment using neurodynamics yielded statistically significant favourable changes in the vibratory threshold in comparison with no intervention in these patients [24].…”