Effect of Growth Hormone Therapy on Serum Adiponectin and Resistin Levels in Short, Small-for-Gestational-Age Children and Associations with Cardiovascular Risk Parameters

Willemsen, Ruben H.; Dijk, Marije van; Rijke, Yolanda B. de; Toorenenbergen, A. W. Van; Mulder, Paul; Hokken-Koelega, Anita

doi:10.1210/jc.2006-0852

Cited by 21 publications

(17 citation statements)

References 57 publications

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“…This discrepancy with the results documented by other authors (25,26,27) may lie in the fact that most studies evaluate heterogeneous groups of SGA children with different BMI. Instead, our results agree with a recent study of Willemsen et al 28 , showing normal adiponectin levels in children born SGA that remain short, who are in general at a lower risk for overweight during the early years of life. The lack of correlation between adiponectin and insulin sensitivity parameters in our population might be due to the low BMI exhibited by the children, even those with catch up growth.…”

Section: Discussionsupporting

confidence: 92%

Serum Levels of Adiponectin and Leptin in Children Born Small for Gestational Age: Relation to Insulin Sensitivity Parameters

Miras

Ochetti

Martin

et al. 2010

Journal of Pediatric Endocrinology and Metabolism

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Children born small for gestational age (SGA) are prone to developing obesity, insulin resistance and type 2 diabetes. Adiponectin and leptin are adipocytokines associated with insulin sensitivity parameters. We aimed to relate serum adiponectin and leptin levels with insulin sensitivity parameters in prepuberal SGA children with and without catch-up growth (SGA+CUG; SGA-CUG, respectively) and to analyze the usefulness of these adipocytokines as early markers of insulin resistance. We analysed adiponectin, proinsulin, leptin, growth factors, insulin, HOMA IR and HOMA βcell in 23 SGA+CUG, 26 SGA-CUG children compared with 48 prepuberal appropiate for gestational age (AGA). SGA children had adiponectin levels comparable to AGA children. Leptin levels were different between sexes, showed to be higher in SGA+CUG group (p=0.040) and these were significantly correlated with insulin sensitivity parameters. These results suggest leptin resistance as an adaptive mechanism to increase energy balance, but an altered functional response of adipocytes cannot be discarded. KEY WORDSsmall for gestational age children, insulin sensitivity, adiponectin, leptin

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Section: Discussionsupporting

confidence: 92%

Serum Levels of Adiponectin and Leptin in Children Born Small for Gestational Age: Relation to Insulin Sensitivity Parameters

Miras

Ochetti

Martin

et al. 2010

Journal of Pediatric Endocrinology and Metabolism

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“…Chen et al reported IGF-1 decreases resistin gene expression and protein secretion in vitro [18]. Willemsen et al performed a 2-year study with infants having low birth weight and short stature according to gestational age [19]. During this period they determined resistin levels in children having high IGF-1 levels and taking GH treatment.…”

Section: Discussionmentioning

confidence: 99%

Serum Resistin and Insulin-Like Growth Factor-1 Levels in Patients with Hypothyroidism and Hyperthyroidism

Koyuncu

Yildirmak

Temizel

et al. 2013

Journal of Thyroid Research

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Introduction. The aim of this study was to evaluate the serum levels of resistin and insulin-like growth factor-1 (IGF-1) and and also the potential relationship between thyroid function and levels of resistin and IGF-1 in hypothyroid and hyperthyroid patients. Methods. Fifteen cases of hypothyroid (HT), 16 of subclinically hypothyroid (SCHT), 15 of hyperthyroid (HrT), 15 of subclinically hyperthyroid (SCHrT), and 17 healthy individuals have been included in the study. Serum resistin levels were measured using enzyme-linked immunosorbent assay and IGF-1 and thyroid stimulating hormone (TSH) levels by chemiluminescence method. Results. Resistin levels in total HT group were significantly higher than in controls (12.66 ± 6.04 and 8.45 ± 2.90 ng/mL, resp.). In SCHrT subgroup resistin levels were significantly higher than those of controls (14.88 ± 7.73 and 8.45 ± 2.90 ng/mL, resp.). IGF-1 levels were significantly lower in total HT than in total HrT and control groups (117.22 ± 52.03, 155.17 ± 51.67, and 184.00 ± 49.73 ng/mL, resp.). Furthermore IGF-1 levels in HT subgroup were significantly lower compared to controls (123.70 ± 44.03 and 184 ± 49.73 ng/mL, resp.). In SCHT subgroup IGF-1 levels were significantly lower than those of control and SCHrT groups (111.11 ± 59.35, 184.00 ± 49.73, and 166.60 ± 47.87 ng/mL, resp.). There were significant correlations between IGF-1 and TSH in HT subgroup and between resistin and TSH in total HrT group. Conclusion. It was concluded that increased resistin levels are directly related to thyroid dysfunction, and GH/IGF-1 axis is influenced in clinically or subclinically hypothyroidism patients.

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“…Furthermore, in a mouse model, the adiponectin levels were negatively correlated with GH, and a role for adiponectin in GH-induced insulin resistance was suggested [40]. However, in another study of SGA children, no association between adiponectin and insulin was found [41]. The last finding is in line with the lack of correlation between the adiponectin levels and fasting insulin levels at any time point in our study for the whole group, as well as for the subgroups AGA/SGA and GHD/ISS.…”

Section: Discussionmentioning

confidence: 99%

Decrease in Adiponectin Levels Correlates to Growth Response in Growth Hormone-Treated Children

Andersson¹,

Carlsson

et al. 2009

Horm Res Paediatr

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Background/Aims: Adiponectin is secreted by adipose tissue and circulates in human plasma at high levels. Decreased adiponectin levels are associated with insulin resistance and obesity. The aim of this study was to investigate whether changes in serum adiponectin levels are related to the growth response, insulin levels and insulin resistance during growth hormone (GH) treatment. Methods: The study included 94 short prepubertal children (19 girls and 75 boys). The mean age at the start of daily GH injections was 9.04 ± 2.38 years. Adiponectin levels in serum were measured using an ELISA. Results: At baseline, adiponectin correlated with the first-year growth response (r = 0.26, p = 0.012). Adiponectin decreased significantly after 1 week, 3 months and 1 year from 14.5 ± 5.71 to 13.1 ± 5.22 (p < 0.0001), 10.3 ± 4.82 (p < 0.0001) and 12.5 ± 5.34 μg/ml (p < 0.0001), respectively. There were significant correlations between the first-year growth response and the decrease in adiponectin levels after 3 months and 1 year (r = –0.38, p < 0.0001 and r = –0.47, p < 0.0001, respectively). No correlations between adiponectin, insulin and the homeostasis model assessment of insulin resistance were seen. Conclusions: GH treatment in prepubertal children decreases serum adiponectin levels, and the decrease is correlated to the growth response. No correlations between adiponectin and insulin levels or insulin resistance were found.

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Effect of Growth Hormone Therapy on Serum Adiponectin and Resistin Levels in Short, Small-for-Gestational-Age Children and Associations with Cardiovascular Risk Parameters

Abstract: Compared with normal-statured controls, short prepubertal SGA children had similar adiponectin and lower resistin levels. Two years of GH treatment had no effect on their adiponectin and resistin levels.

Cited by 21 publications

References 57 publications

Serum Levels of Adiponectin and Leptin in Children Born Small for Gestational Age: Relation to Insulin Sensitivity Parameters

Serum Levels of Adiponectin and Leptin in Children Born Small for Gestational Age: Relation to Insulin Sensitivity Parameters

Serum Resistin and Insulin-Like Growth Factor-1 Levels in Patients with Hypothyroidism and Hyperthyroidism

Decrease in Adiponectin Levels Correlates to Growth Response in Growth Hormone-Treated Children

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