Effect of growth hormone of free fatty acid metabolism

Winkler, B.; Steele, Robert D.; Altszuler, N.; Bodo, R. C. de

doi:10.1152/ajplegacy.1964.206.1.174

Cited by 46 publications

(17 citation statements)

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“…Bodel, Rubenstein, McGarry, and Beck failed to show enhanced oxidation of palmitic acid-i-C14 by excised rat diaphragm either by addition of growth hormone in vitro or by pretreatment of the animals with growth hormone (25). On the other hand, de Bodo and colleagues (26,27), on the basis of studies in which C14 palmitate was infused into normal dogs, reported that growth hormone administration increased the turnover rate of FFA, the amount of FFA oxidized to CO2, and the fraction of total respiratory CO2 derived from FFA oxidation.…”

Section: Discussionmentioning

confidence: 95%

Effect of Human Growth Hormone on Muscle and Adipose Tissue Metabolism in the Forearm of Man *

Rabinowitz¹,

Klassen²,

Zierler³

1965

J. Clin. Invest.

161

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Section: Discussionmentioning

confidence: 95%

Effect of Human Growth Hormone on Muscle and Adipose Tissue Metabolism in the Forearm of Man *

Rabinowitz¹,

Klassen²,

Zierler³

1965

J. Clin. Invest.

161

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“…In this study, the fasting FFA levels in the four infants ill with marasmus were greater than the mean of the group, being 738, 920, 1000, and 1409 moles/liter. High levels of FFA are associated with increased FFA flux [13], which may also be due to the high GH [31] and low insulin levels in plasma.…”

Section: Discussionmentioning

confidence: 99%

Metabolic and Hormonal Responses to Glucose and Glucagon in Patients with Infantile Malnutrition

Milner¹

1971

Pediatr Res

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ExtractThe interrelations of plasma levels of glucose, free fatty acids (FFA), a-amino nitrogen (a-aaN), insulin, and growth hormone (GH) were studied in 26 malnourished infants shortly after admission to the hospital and again several weeks later when they had recovered. In the sick children (SC) fasting levels of FFA and GH were high, and insulin and a-aaN were low; with recovery FFA, a-aaN and insulin levels became normal, and GH levels fell. No change occurred in glucose levels.Ten infants were given glucose (0.5 g/kg body weight) intravenously on the 1st or 2nd day after admission and again 6-12 weeks later. Glucose tolerance was impaired in the sick group and, although improved, was not normal when the children had recovered from the nutritional insult. Insulin secretion was stimulated by glucose in those that had recovered (RC), but not in the SC. No significant change occurred in either FFA or a-aaN levels in these groups.Nine infants received glucagon (0.1 mg/kg body weight) intravenously on the 2nd to 6th day after admission and again 6-12 weeks later. Glucagon caused a rise in glucose levels that were greater in RC than in SC but did not cause a significant change in insulin levels in either group. Free fatty acid levels were higher in SC throughout the test, but in both groups FFA levels responded similarly to glucagon administration, falling 10 and 60 min after the injection.Changes in GH levels in plasma after glucose or glucagon administration were compared with the changes caused by five venepunctures in RC. Venepunctures and glucose caused similar rises in GH levels, but glucagon caused a greater rise than either. It was concluded that the stress of repeated venepunctures caused a rise in GH levels in plasma in all three tests, but that, independent of this, glucagon stimulated GH secretion. SpeculationInsulin secretion is impaired in infantile malnutrition and does not improve at the same rate as clinical recovery occurs, suggesting that normal /? cell function is not essential for rapid growth. The role of growth hormone in malnutrition is not clear, but it appears to be involved more in the metabolic adaptation to malnutrition than in the control of growth.

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“…Measurements of irreversible losses of glucose, acetate and palmitate were made by continuous intravenous infusion of the appropriate metabolite via one jugular catheter and subsequent collection of blood samples from the contralateral catheter. Palmitic acid was bound to plasma proteins (using fresh plasma from individual animals) as described by Winkler et al (1964). Infusion rates for each labelled metabolite were recorded.…”

Section: Metabolite Biokineticsmentioning

confidence: 99%

“…Specific radioactivities of respective metabolites were measured according to the procedures outlined by Jones (1965) for glucose; Pethick et al (1981) for acetate; Winkler et al (1964) for NEFA. Thus glucose was isolated as glucose penta-acetate, acetate was isolated as the volatile acid and total NEFA were separated from other labelled metabolites.…”

Section: Metabolite Biokineticsmentioning

confidence: 99%

Effects of Pituitary-derived Bovine Growth Hormone on Production Parameters and Biokinetics of Key Metabolites in Lactating Dairy Cows at Peak and Mid-lactation

McDowell¹,

Hart²,

Ja³

et al. 1987

Aust. Jnl. Of Bio. Sci.

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Changes in production parameters and metabolite biokinetics induced by treatment with pituitary-derived bovine growth hormone (bGH) were monitored at peak (c. 40 days) and mid-lactation (c. 130 days) in dairy cows.During treatment with bGH milk production increased by 6 and 14% at peak and mid-lactation respectively. At peak lactation the content of milk fat tended to increase, whereas milk protein tended to decrease and milk lactose decreased significantly. Yield of milk fat increased, but there was no change in the yield of milk protein and lactose. The content of milk fat tended to increase at mid-lactation. Milk protein decreased and there was no change in milk lactose. Yields of milk fat and lactose but not protein increased. Growth hormone exerted metabolic effects which differed with stage of lactation. At peak lactation plasma glucose concentration and its irreversible loss increased, plasma urea and acetate were unchanged and their irreversible losses tended to increase. No change was measured for plasma non-esterified fatty acids (NEFA) and the irreversible loss of NEF A decreased. At mid-lactation plasma concentrations of glucose and NEF A were increased, plasma urea decreased and acetate and 3-hydroxybutyrate tended to increase. Irreversible losses of NEFA increased, urea tended to decrease and acetate and glucose remained essentially constant.The results show that exogenous pituitary bGH exerts metabolic effects which result in the supply of increased nutrients to support milk synthesis. The metabolic effects differ with the stage of lactation, reflecting differences in physiological andlor nutritional state.

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Effect of growth hormone of free fatty acid metabolism

Cited by 46 publications

References 0 publications

Effect of Human Growth Hormone on Muscle and Adipose Tissue Metabolism in the Forearm of Man *

Effect of Human Growth Hormone on Muscle and Adipose Tissue Metabolism in the Forearm of Man *

Metabolic and Hormonal Responses to Glucose and Glucagon in Patients with Infantile Malnutrition

Effects of Pituitary-derived Bovine Growth Hormone on Production Parameters and Biokinetics of Key Metabolites in Lactating Dairy Cows at Peak and Mid-lactation

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