2012
DOI: 10.1039/c2nr30407d
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Abstract: Graphene oxide (GO), has created an unprecedented opportunity for development and application in biology, due to its abundant functional groups and well water solubility. Recently, the potential toxicity of GO in the environment and in humans has garnered more and more attention. In this paper, we systematically studied the cytotoxicity of GO nanosheets via examining the effect of GO on the morphology, viability and differentiation of a human neuroblastoma SH-SY5Y cell line, which was an ideal model used to st… Show more

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Cited by 151 publications
(130 citation statements)
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“…62 In addition, GO induced neuronal differentiation of neuroblastoma SH-SY5Y cells. 29 Our findings suggest that GO-AgNPs composites were able to inhibit proliferation and would not promote proliferation. Therefore, the mechanism of GO on cell proliferation merely depends on the concentration and type of cells, as well as the size, surface charge, surface chemistry, oxidation time, and several other factors.…”
mentioning
confidence: 79%
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“…62 In addition, GO induced neuronal differentiation of neuroblastoma SH-SY5Y cells. 29 Our findings suggest that GO-AgNPs composites were able to inhibit proliferation and would not promote proliferation. Therefore, the mechanism of GO on cell proliferation merely depends on the concentration and type of cells, as well as the size, surface charge, surface chemistry, oxidation time, and several other factors.…”
mentioning
confidence: 79%
“…Similarly, our studies have shown the toxicity of GO and biomolecule-functionalized reduced graphene in various types of cancer and non-cancer cells, including mouse embryonic fibroblast cells, 26 human breast cancer cells, 27 and human ovarian cancer cells. 28 GO induced cytotoxicity in human neuroblastoma SH-SY5Y cells at higher concentrations of 80 µg/mL at 96 h in a dose-and timedependent manner, 29 and GO nanoribbons induced toxicity by generation of reactive oxygen species (ROS), impairment of mitochondrial membrane potential (MMP), and formation of autophagosomes (APs), 30 which also depends on the size, charge, surface chemistry, and physical and chemical nature of the synthesized graphene. 27,28,31,32 On the other hand, the biocompatibility was analyzed using a variety of chemically and biologically functionalized graphene in several cell lines.…”
Section: Introductionmentioning
confidence: 99%
“…29,30 Graphene oxide, especially at low concentrations, does not show obvious cytotoxic effects on the human-derived cell lines A549 and SH-SY5Y. 31,32 However, graphene oxide reduces glioblastoma cell viability and proliferation with increasing doses. 12 The toxicity of graphene oxide on mesenchymal stem cells depends on the size of the nanoparticles.…”
Section: Resultsmentioning
confidence: 99%
“…So far, the studies on influence of GO mostly focused on mammalian cells. In the SH-SY5Y cell line, GO had no obvious cytotoxicity at low concentration (< 80 μg/mL) for 96 h, but the viability of cells exhibited dose-and time-dependent decreases at high concentration (> 80 μg/mL) [4]. The result in cytotoxicity of different oxidation degrees (GO-high, medium and low) on mouse embryo fibroblasts cells found that lower oxidation degree of GO induced stronger toxicity and a higher level of oxidative stress [5].…”
Section: Introductionmentioning
confidence: 99%