Effect of goserelin on the quality of life of women with benign gynecological disorders: a systematic review

Abstract

Objective: Goserelin reduces the estrogen levels and is approved for several hormonally sensitive benign disorders. There are few data about the quality of life of women using goserelin for benign disorders. The purpose of this article is to objectively assess the quality of life of these women. Methods: We searched from electronic databases as PubMed, Scielo, LILACS, among others. The inclusion criteria were RCTs which evaluated using validated questionnaires the quality of life of women with benign gynecological disorders treated with goserelin. Results: The five RCTs demonstrated improvement in quality of life after goserelin compared to the baseline. It was evidenced a temporary effect of the goserelin. Goserelin by itself or associated with another therapy improves the quality of life when compared to the baseline. Hot flushes are not an expressive cause of patient noncompliance. The temporary effect of goserelin is in accordance with literature. Final considerations: This systematic review suggests that goserelin is an effective treatment for benign gynecological disorders, but more studies are necessary to embark therapy choice.