Effect of ginsenoside CK combined with cisplatin on the proliferation and migration of human cervical cancer HeLa cells via Ras/ERK/MAPK pathway

Novel NF-κB Inhibitor-Conjugated Pt(IV) Prodrug to Enable Cancer Therapy through ROS/ER Stress and Mitochondrial Dysfunction and Overcome Multidrug Resistance

“…It is well-known that the MAPK signaling pathway plays a major role in regulating cell survival, proliferation, and apoptosis and is an important sensor of cellular stress downstream of NF-κB in many tumorigenic functions. − To further investigate the effect of the Pt­(IV) complex 9 on the MAPK/NF-κB signaling pathway, the relative proteins including p38, p-p38, ERK, p-ERK, p-NF-κB (p65), p-IKKβ, and p-IκBα were evaluated by Western blotting assays. The results in Figure A indicate that complex 9 and the combination of cisplatin and 4 showed greater potential to elevate the expression levels of p-p38 and reduce the expression of p-ERK compared to other treatment groups, while the expression of p38 and ERK changed only slightly.…”

The ethyl acetate extract of Vernonia amygdalina leaf ameliorates gemcitabine effect against migration and invasion of PANC-1 cells via down-regulation the VEGF, COX2, and RAS/MEK pathways

“…The RAS/MEK pathways exhibit a noteworthy association with the migratory and invasive behavior of PANC-1 cells at the molecular level ( Buscail et al, 2020 ). The study reports that the combination of ginsenoside and cisplatin effectively inhibited cell migration in HeLa cells by suppressing the RAS/MEK/ERK pathways ( Li et al, 2023 ). Anthocyanins derived from black rice were found to inhibit cell migration and invasion by suppressing MEK in various other cell lines ( Chen et al, 2015 ).…”