Effect of gastrin on lower oesophageal sphincter characteristics and gastro-oesophageal reflux

Active and Inactive Gastroesophageal Reflux Diseases Related to Helicobacter pylori Therapy

“…showed an increase [70], and Straathof et al. reported a decrease in LES pressure in humans [71]. Furthermore, endogenous serum gastrin level after the intake of protein food increased with an increased LES pressure in duodenal ulcer patients, but with a decreased LES pressure in gastric ulcer patients [72].…”

Active and Inactive Gastroesophageal Reflux Diseases Related to Helicobacter pylori Therapy

“…showed an increase [70], and Straathof et al. reported a decrease in LES pressure in humans [71]. Furthermore, endogenous serum gastrin level after the intake of protein food increased with an increased LES pressure in duodenal ulcer patients, but with a decreased LES pressure in gastric ulcer patients [72].…”

Responses of human sling and clasp fibers to cholecystokinin (CCK) and gastrin through CCK receptors

“…However, the mechanism of CCK action on the LES function seems to vary between different mammalian species, and different researchers have reported different outcomes from similar experiments in the same species 17–26 . Hence the conclusions drawn from the studies which have investigated the effect of CCK and gastrin on LES function are controversial 24,27,28 . Unfortunately, previous studies have usually used experimental animal models, and our study is the first to actually investigate differences between LES sling and clasp fiber function, and the role of CCK and gastrin, in human tissue.…”

Duodenal ulcer disease, gastroduodenal motor function and reflux esophagitis – a cross‐sectional survey in a subset of Taiwanese patients

“…Using sleeve sensor measurement, Straathof et al. have shown a decrease of lower esophageal sphincter pressure and increase of the percentage of tLESR associated with reflux after intravenous infusion to plasma gastrin level in physiological postprandial range 25 . Exogenous gastrin has been reported to induce fundal relaxation and increase gastric wall compliance in healthy subjects 26 .…”

Active and Inactive Gastroesophageal Reflux Diseases Related to Helicobacter pylori Therapy

“…showed an increase [70], and Straathof et al. reported a decrease in LES pressure in humans [71]. Furthermore, endogenous serum gastrin level after the intake of protein food increased with an increased LES pressure in duodenal ulcer patients, but with a decreased LES pressure in gastric ulcer patients [72].…”

Responses of human sling and clasp fibers to cholecystokinin (CCK) and gastrin through CCK receptors

“…However, the mechanism of CCK action on the LES function seems to vary between different mammalian species, and different researchers have reported different outcomes from similar experiments in the same species 17–26 . Hence the conclusions drawn from the studies which have investigated the effect of CCK and gastrin on LES function are controversial 24,27,28 . Unfortunately, previous studies have usually used experimental animal models, and our study is the first to actually investigate differences between LES sling and clasp fiber function, and the role of CCK and gastrin, in human tissue.…”

Duodenal ulcer disease, gastroduodenal motor function and reflux esophagitis – a cross‐sectional survey in a subset of Taiwanese patients

“…Using sleeve sensor measurement, Straathof et al. have shown a decrease of lower esophageal sphincter pressure and increase of the percentage of tLESR associated with reflux after intravenous infusion to plasma gastrin level in physiological postprandial range 25 . Exogenous gastrin has been reported to induce fundal relaxation and increase gastric wall compliance in healthy subjects 26 .…”

Active and Inactive Gastroesophageal Reflux Diseases Related to Helicobacter pylori Therapy

“…showed an increase [70], and Straathof et al. reported a decrease in LES pressure in humans [71]. Furthermore, endogenous serum gastrin level after the intake of protein food increased with an increased LES pressure in duodenal ulcer patients, but with a decreased LES pressure in gastric ulcer patients [72].…”

Responses of human sling and clasp fibers to cholecystokinin (CCK) and gastrin through CCK receptors

“…However, the mechanism of CCK action on the LES function seems to vary between different mammalian species, and different researchers have reported different outcomes from similar experiments in the same species 17–26 . Hence the conclusions drawn from the studies which have investigated the effect of CCK and gastrin on LES function are controversial 24,27,28 . Unfortunately, previous studies have usually used experimental animal models, and our study is the first to actually investigate differences between LES sling and clasp fiber function, and the role of CCK and gastrin, in human tissue.…”

Duodenal ulcer disease, gastroduodenal motor function and reflux esophagitis – a cross‐sectional survey in a subset of Taiwanese patients

“…Using sleeve sensor measurement, Straathof et al. have shown a decrease of lower esophageal sphincter pressure and increase of the percentage of tLESR associated with reflux after intravenous infusion to plasma gastrin level in physiological postprandial range 25 . Exogenous gastrin has been reported to induce fundal relaxation and increase gastric wall compliance in healthy subjects 26 .…”